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Condensed Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Operating activities    
Net loss $ (22,564) $ (26,955)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,839 2,602
Bad debt expense 0 68
Loss on disposal of property and equipment 0 12
Genzyme co-promotion fee amortization 0 (948)
Stock-based compensation 4,825 4,745
Conversion of accrued interest on long-term debt 0 385
Amortization and write-off of debt discount and issuance costs 79 146
Interest on debt balloon payment and prepayment penalty 0 206
Changes in operating assets and liabilities:    
Accounts receivable (2,879) (2,877)
Supplies inventory (285) 351
Prepaid expenses and current other assets 240 37
Other assets (44) (44)
Accounts payable 891 (387)
Accrued liabilities and deferred rent (1,201) (1,091)
Net cash used in operating activities (18,099) (23,750)
Investing activities    
Purchases of property and equipment (1,455) (3,760)
Proceeds from sale of property and equipment 440 0
Change in restricted cash 120 (2)
Net cash used in investing activities (895) (3,762)
Financing activities    
Proceeds from the issuance of long-term debt, net of debt issuance costs 0 24,452
Payment of long-term debt 0 (5,000)
Payment of end-of-term debt obligation and prepayment penalty 0 (288)
Proceeds from the issuance of common stock in a public offering, net of costs 200 0
Payment of capital lease liability (204) 0
Proceeds from the exercise of common stock options and employee stock purchases 974 963
Net cash provided by financing activities 970 20,127
Net decrease in cash and cash equivalents (18,024) (7,385)
Cash and cash equivalents at beginning of period 59,219 39,084
Cash and cash equivalents at end of period 41,195 31,699
Supplementary cash flow information of non-cash investing and financing activities:    
Purchases of property and equipment included in accounts payable and accrued liabilities $ 188 $ 0