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Commitments and Contingencies - Operating Lease (Details)
ft² in Thousands, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
ft²
Sep. 30, 2017
USD ($)
Dec. 31, 2017
USD ($)
Future minimum lease payments under non-cancelable operating leases          
Remainder of 2018 $ 516   $ 516    
2019 2,227   2,227    
2020 2,332   2,332    
2021 2,401   2,401    
2022 2,472   2,472    
Thereafter 9,384   9,384    
Total minimum lease payments 19,332   19,332    
Facilities rent expense 476 $ 469 $ 1,400 $ 1,400  
Headquarters and laboratory facilities, South San Francisco, lease signed April 2015          
Operating Leases          
Amount of space leased (in square feet) | ft²     59    
Security deposit 603   $ 603   $ 603
Laboratory facilities, Austin, Texas | Other assets          
Operating Leases          
Security deposit $ 139   $ 139   $ 139