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Condensed Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Operating activities    
Net loss $ (19,894) $ (22,564)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,950 2,839
Stock-based compensation 4,425 4,825
Other income (93) 0
Amortization of debt issuance costs 24 79
Interest on end-of-term debt obligation 230 0
Changes in operating assets and liabilities:    
Accounts receivable 454 (2,879)
Supplies 1,861 (285)
Prepaid expenses and current other assets 61 240
Other assets (511) (44)
Accounts payable (2,636) 891
Accrued liabilities and deferred rent 834 (1,201)
Net cash used in operating activities (12,295) (18,099)
Investing activities    
Purchases of property and equipment (1,420) (1,455)
Proceeds from sale of property and equipment 0 440
Net cash used in investing activities (1,420) (1,015)
Financing activities    
Proceeds from the issuance of common stock in a public offering, net of costs 55,039 200
Proceeds from legal settlement regarding short-swing profits 403 0
Payment of capital lease liability (217) (204)
Proceeds from the exercise of common stock options and employee stock purchases 2,445 974
Net cash provided by financing activities 57,670 970
Net increase (decrease) in cash, cash equivalents and restricted cash 43,955 (18,144)
Cash, cash equivalents and restricted cash at beginning of period 34,494 59,942
Cash, cash equivalents and restricted cash at end of period 78,449 41,798
Supplementary cash flow information of non-cash investing and financing activities:    
Total cash, cash equivalents and restricted cash 34,494 59,942
Purchases of property and equipment included in accounts payable and accrued liabilities 23 188
Interest paid on debt $ 1,235 $ 2,318