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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Operating activities    
Net loss $ (8,091) $ (14,461)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 6,670 6,556
Loss on disposal of property, plant and equipment 121 0
Stock-based compensation 7,985 6,645
Benefit from income taxes 0 (3)
Interest on end-of-term debt obligation 0 53
Noncash lease expense 903 587
Revaluation of acquisition-related contingent consideration (485) 31
Effect of foreign currency on operations (224) 131
Impairment loss 1,410 0
Changes in operating assets and liabilities:    
Accounts receivable (1,302) (3,575)
Supplies and inventory 1,055 (1,201)
Prepaid expenses and other current assets (3,064) (2,139)
Other assets (491) 451
Operating lease liabilities (950) (597)
Accounts payable 2,012 (960)
Accrued liabilities and deferred revenue (7,721) (390)
Net cash used in operating activities (2,172) (8,872)
Investing activities    
Purchase of short-term investments (19,700) 0
Proceeds from sale of short-term investments 39,773 0
Proceeds from maturity of short-term investments 5,000 0
Purchases of property, plant and equipment (993) (2,453)
Net cash provided by (used in) investing activities 24,080 (2,453)
Financing activities    
Payment of long-term debt 0 (100)
Payment of taxes on vested restricted stock units (2,277) (1,447)
Proceeds from the exercise of common stock options and employee stock purchases 3,962 3,537
Net cash provided by financing activities 1,685 1,990
Increase (decrease) in cash, cash equivalents and restricted cash 23,593 (9,335)
Effect of foreign currency on cash, cash equivalents and restricted cash 50 (247)
Net increase (decrease) in cash, cash equivalents and restricted cash 23,643 (9,582)
Cash, cash equivalents and restricted cash at beginning of period 154,996 173,946
Cash, cash equivalents and restricted cash at end of period 178,639 164,364
Supplementary cash flow information:    
Purchases of property, plant and equipment included in accounts payable and accrued liability 1,624 342
Cash and cash equivalents 177,890  
Restricted cash 749  
Total cash, cash equivalents and restricted cash $ 178,639 $ 164,364