<SEC-DOCUMENT>0001439222-26-000008.txt : 20260102
<SEC-HEADER>0001439222-26-000008.hdr.sgml : 20260102
<ACCEPTANCE-DATETIME>20260102201610
ACCESSION NUMBER:		0001439222-26-000008
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251230
FILED AS OF DATE:		20260102
DATE AS OF CHANGE:		20260102

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Goff Brian
		CENTRAL INDEX KEY:			0001546216
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36014
		FILM NUMBER:		26503610

	MAIL ADDRESS:	
		STREET 1:		C/O AGIOSPHARMACEUTICALS, INC
		STREET 2:		88 SIDNEY STREET
		CITY:			CAMBRIDGE
		STATE:			CT
		ZIP:			02139

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AGIOS PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001439222
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		88 SIDNEY STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-649-8600

	MAIL ADDRESS:	
		STREET 1:		88 SIDNEY STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AGIOS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20080703
</SEC-HEADER>
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<SEQUENCE>1
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        <issuerName>AGIOS PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>AGIO</issuerTradingSymbol>
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            <rptOwnerName>Goff Brian</rptOwnerName>
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            <rptOwnerStreet2>88 SIDNEY STREET</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02139</rptOwnerZipCode>
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            <isTenPercentOwner>0</isTenPercentOwner>
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            <officerTitle>Chief Executive Officer</officerTitle>
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    <footnotes>
        <footnote id="F1">Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated August 8, 2022.</footnote>
        <footnote id="F2">Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's performance share unit agreement dated March 1, 2023.</footnote>
        <footnote id="F3">Each performance share unit represents a contingent right to receive one share of the issuer's common stock.</footnote>
        <footnote id="F4">The PSUs were granted on August 8, 2022. The PSUs vest as to 15% of the underlying shares upon the achievement of a specified research milestone and as to the remaining underlying shares upon the achievement of other clinical and regulatory milestones. The performance criteria for the specified regulatory milestone was determined to have been met on December 29, 2025, resulting in the vesting of the PSUs as to 15% of the underlying shares of common stock. Vested shares will be delivered to the reporting person within three business days after such shares become vested.</footnote>
        <footnote id="F5">The PSUs were granted on March 1, 2023. The PSUs vest as to 50% of the underlying shares upon the achievement of a specified research milestone and as to the remaining 50% of the underlying shares upon the achievement of a specified regulatory milestone. The performance criteria for the specified regulatory milestone was determined to have been met on December 29, 2025, resulting in the vesting of the PSUs as to 50% of the underlying shares. Vested shares will be delivered to the reporting person within three business days after such shares become vested.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ William Cook, as Attorney in Fact for Brian Goff</signatureName>
        <signatureDate>2026-01-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
