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v3.26.1

Segment Information (Tables) | 6 Months Ended
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Jun. 30, 2026
Segment Reporting [Abstract] |
Schedule of Significant Segment Expense Categories | In addition, the CODM is regularly provided the significant segment expense categories included in the table below (in thousands), which are reviewed against budgeted expectations to assist in resource allocation decision-making.
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2026 |  |  | 2025 |  |  | 2026 |  |  | 2025 |
Bitopertin program external expense |  | $ | (8,666 | ) |  | $ | (23,686 | ) |  | $ | (18,006 | ) |  | $ | (32,121 | )
Selcodebart (DISC-0974) program external expense |  |  | (12,354 | ) |  |  | (4,615 | ) |  |  | (20,463 | ) |  |  | (10,736 | )
DISC-3405 program external expense |  |  | (4,960 | ) |  |  | (1,908 | ) |  |  | (14,147 | ) |  |  | (3,576 | )
Other external research and development expense |  |  | (2,697 | ) |  |  | (3,103 | ) |  |  | (4,862 | ) |  |  | (4,935 | )
Internal and other research and development expense |  |  | (11,261 | ) |  |  | (9,145 | ) |  |  | (22,573 | ) |  |  | (15,893 | )
Commercial expense |  | $ | (3,083 | ) |  | $ | (2,660 | ) |  | $ | (11,517 | ) |  | $ | (4,581 | )
General and administrative expense |  | $ | (8,106 | ) |  | $ | (7,873 | ) |  | $ | (17,137 | ) |  | $ | (14,731 | )
Stock-based compensation expense |  | $ | (13,948 | ) |  | $ | (8,420 | ) |  | $ | (25,894 | ) |  | $ | (14,783 | )
Other segment items* |  | $ | 5,543 |  |  | $ | 6,163 |  |  | $ | 11,563 |  |  | $ | 12,024 |
Net loss |  | $ | (59,532 | ) |  | $ | (55,247 | ) |  | $ | (123,036 | ) |  | $ | (89,332 | )
*Other segment items include interest income, interest expense, other (expense) income, and income tax expense as reported on the condensed consolidated statements of operations and comprehensive loss.

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- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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