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Segment Information | 6 Months Ended
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Jun. 30, 2026
Segment Reporting [Abstract] |
Segment Information | 13. Segment Information The Company manages its operations as a single operating segment for the purposes of assessing performance and making operating decisions, resulting in a single reportable segment. The Company has determined that its Chief Operating Decision Maker ("CODM") is its Chief Executive Officer. The Company’s CODM reviews the Company’s financial information on a consolidated basis for the purpose of allocating resources and assessing financial performance. The key measure of segment profit or loss that the CODM uses to allocate resources and assess performance is the Company’s consolidated net loss, as reported on the condensed consolidated statements of operations and comprehensive loss. In addition, the CODM is regularly provided the significant segment expense categories included in the table below (in thousands), which are reviewed against budgeted expectations to assist in resource allocation decision-making.
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2026 |  |  | 2025 |  |  | 2026 |  |  | 2025 |
Bitopertin program external expense |  | $ | (8,666 | ) |  | $ | (23,686 | ) |  | $ | (18,006 | ) |  | $ | (32,121 | )
Selcodebart (DISC-0974) program external expense |  |  | (12,354 | ) |  |  | (4,615 | ) |  |  | (20,463 | ) |  |  | (10,736 | )
DISC-3405 program external expense |  |  | (4,960 | ) |  |  | (1,908 | ) |  |  | (14,147 | ) |  |  | (3,576 | )
Other external research and development expense |  |  | (2,697 | ) |  |  | (3,103 | ) |  |  | (4,862 | ) |  |  | (4,935 | )
Internal and other research and development expense |  |  | (11,261 | ) |  |  | (9,145 | ) |  |  | (22,573 | ) |  |  | (15,893 | )
Commercial expense |  | $ | (3,083 | ) |  | $ | (2,660 | ) |  | $ | (11,517 | ) |  | $ | (4,581 | )
General and administrative expense |  | $ | (8,106 | ) |  | $ | (7,873 | ) |  | $ | (17,137 | ) |  | $ | (14,731 | )
Stock-based compensation expense |  | $ | (13,948 | ) |  | $ | (8,420 | ) |  | $ | (25,894 | ) |  | $ | (14,783 | )
Other segment items* |  | $ | 5,543 |  |  | $ | 6,163 |  |  | $ | 11,563 |  |  | $ | 12,024 |
Net loss |  | $ | (59,532 | ) |  | $ | (55,247 | ) |  | $ | (123,036 | ) |  | $ | (89,332 | )
*Other segment items include interest income, interest expense, other (expense) income, and income tax expense as reported on the condensed consolidated statements of operations and comprehensive loss. Assets regularly provided to the CODM are consistent with those reported on the condensed consolidated balance sheets with particular emphasis on the Company’s available liquidity, including its cash, cash equivalents and marketable securities balances. All of the Company’s tangible assets are held in the United States.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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