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Segment Information (Tables)
 6 Months Ended
Jun. 30, 2026
Segment Reporting [Abstract]  
Schedule of Significant Segment Expense Categories In addition, the CODM is regularly provided the significant segment expense categories included in the table below (in thousands), which are reviewed against budgeted expectations to assist in resource allocation decision-making.

 

Three Months Ended
June 30,

 

 

Six Months Ended
June 30,

 

 

2026

 

 

2025

 

 

2026

 

 

2025

 

Bitopertin program external expense

 

$

(8,666

)

 

$

(23,686

)

 

$

(18,006

)

 

$

(32,121

)

Selcodebart (DISC-0974) program external expense

 

 

(12,354

)

 

 

(4,615

)

 

 

(20,463

)

 

 

(10,736

)

DISC-3405 program external expense

 

 

(4,960

)

 

 

(1,908

)

 

 

(14,147

)

 

 

(3,576

)

Other external research and development expense

 

 

(2,697

)

 

 

(3,103

)

 

 

(4,862

)

 

 

(4,935

)

Internal and other research and development expense

 

 

(11,261

)

 

 

(9,145

)

 

 

(22,573

)

 

 

(15,893

)

 

 

 

 

 

 

 

 

 

 

 

 

 

Commercial expense

 

$

(3,083

)

 

$

(2,660

)

 

$

(11,517

)

 

$

(4,581

)

 

 

 

 

 

 

 

 

 

 

 

 

 

General and administrative expense

 

$

(8,106

)

 

$

(7,873

)

 

$

(17,137

)

 

$

(14,731

)

 

 

 

 

 

 

 

 

 

 

 

 

 

Stock-based compensation expense

 

$

(13,948

)

 

$

(8,420

)

 

$

(25,894

)

 

$

(14,783

)

 

 

 

 

 

 

 

 

 

 

 

 

 

Other segment items*

 

$

5,543

 

 

$

6,163

 

 

$

11,563

 

 

$

12,024

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Net loss

 

$

(59,532

)

 

$

(55,247

)

 

$

(123,036

)

 

$

(89,332

)

 

*Other segment items include interest income, interest expense, other (expense) income, and income tax expense as reported on the condensed consolidated statements of operations and comprehensive loss.