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Segment Information - Schedule of Significant Segment Expense Categories (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Mar. 31, 2026
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2026
Jun. 30, 2025
Segment Reporting Information [Line Items]            
Research and development expense $ (46,933)   $ (46,319)   $ (92,837) $ (74,082)
Stock-based compensation expense (13,948)   (8,420)   (25,894) (14,783)
Net loss (59,532) $ (63,504) (55,247) $ (34,085) (123,036) (89,332)
Significant Segment Expense Category [Member]            
Segment Reporting Information [Line Items]            
Commercial expense (3,083)   (2,660)   (11,517) (4,581)
General and administrative expense (8,106)   (7,873)   (17,137) (14,731)
Stock-based compensation expense (13,948)   (8,420)   (25,894) (14,783)
Other Segment Items [Member]            
Segment Reporting Information [Line Items]            
Other segment items 5,543   6,163   11,563 12,024
Key Measure of Segment Profit or Loss [Member]            
Segment Reporting Information [Line Items]            
Net loss (59,532)   (55,247)   (123,036) (89,332)
Bitopertin [Member] | Significant Segment Expense Category [Member]            
Segment Reporting Information [Line Items]            
Research and development expense (8,666)   (23,686)   (18,006) (32,121)
Selcodebart [Member] | Significant Segment Expense Category [Member]            
Segment Reporting Information [Line Items]            
Research and development expense (12,354)   (4,615)   (20,463) (10,736)
DISC-3405 [Member] | Significant Segment Expense Category [Member]            
Segment Reporting Information [Line Items]            
Research and development expense (4,960)   (1,908)   (14,147) (3,576)
Other Research [Member] | Significant Segment Expense Category [Member]            
Segment Reporting Information [Line Items]            
Research and development expense (2,697)   (3,103)   (4,862) (4,935)
Internal Research and Development [Member] | Significant Segment Expense Category [Member]            
Segment Reporting Information [Line Items]            
Research and development expense $ (11,261)   $ (9,145)   $ (22,573) $ (15,893)