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Income Taxes - Additional Information (Detail) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Line Items]        
Valuation allowance, deferred tax assets $ 47,413,000 $ 43,329,000    
Research and development tax credit carryforwards 33,764,000 36,041,000    
Accrued interest 3,474,000 3,246,000 $ 2,297,000 $ 2,070,000
Net interest expense 17,000 19,000 $ 17,000  
Potential payment of interest 52,000 52,000    
Stock-based compensation 3,940,000 2,341,000    
Maximum [Member]        
Income Tax Disclosure [Line Items]        
Stock-based compensation $ 49,500,000 $ 55,300,000    
Domestic Tax Authority [Member]        
Income Tax Disclosure [Line Items]        
Federal net operating loss carryforwards expiry, beginning year 2026      
Research and development tax credit carryforwards $ 21,949,000      
Net operating loss carryforwards $ 0      
Certain States [Member]        
Income Tax Disclosure [Line Items]        
Federal net operating loss carryforwards expiry, beginning year 2023      
Research and development tax credit carryforwards $ 19,308,000      
State and Local Jurisdiction [Member]        
Income Tax Disclosure [Line Items]        
Federal net operating loss carryforwards expiry, beginning year 2025      
Net operating loss carryforwards $ 3,607,000