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Condensed Consolidated Statements of Cash Flows (Unaudited)
$ in Thousands
 6 Months Ended
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Cash flows from operating activities:    
Net loss $ (50,619) $ (35,505)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 5,098 4,210
Accretion of final payment fee on term loan 245  
Amortization of debt issuance costs 152 194
Amortization of premium on available-for-sale securities 128 472
Non-cash operating lease expense 91  
Depreciation 34 35
Changes in operating assets and liabilities:    
Prepaid and other current assets 4,037 (4,032)
Other assets (507) 77
Accounts payable (1,936) (159)
Accrued expenses 4,194 (383)
Operating lease liability (96)  
Net cash used in operating activities (39,179) (35,091)
Cash flows from investing activities:    
Proceeds from maturities of available-for-sale securities 59,912 63,952
Purchases of available-for-sale securities (40,731) (93,218)
Purchases of property and equipment (5) (20)
Net cash provided by (used in) investing activities 19,176 (29,286)
Cash flows from financing activities:    
Proceeds from public offering, prior to closing 28,186  
Proceeds from issuance of common stock upon ESPP purchases 43 83
Proceeds from issuance of common stock upon stock option exercises 29 368
Payment of withholding taxes related to restricted stock units (69)  
Proceeds from term loan facility, net of issuance costs   1,457
Net cash provided by financing activities 28,189 1,908
Net change in cash and cash equivalents, and restricted cash 8,186 (62,469)
Cash and cash equivalents, and restricted cash at beginning of period 52,457 98,208
Cash and cash equivalents, and restricted cash at end of period 60,643 35,739
Components of cash and cash equivalents, and restricted cash:    
Cash and cash equivalents 60,618 35,714
Restricted cash 25 25
Total cash and cash equivalents, and restricted cash 60,643 35,739
Supplemental disclosures of cash information:    
Cash paid for interest 404  
Cash paid for operating leases 127  
Supplemental disclosures of non-cash information:    
Offering costs included in other assets and accrued expenses $ 580  
Purchases of property and equipment included in accounts payable and accrued expenses   3
Issuance of common stock warrant in connection with term loan facility   574
Debt issuance costs included in accounts payable   $ 6