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Subsequent Events - Additional Information (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 2 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Feb. 15, 2023 | Jan. 31, 2023 | Jul. 31, 2022 | Mar. 31, 2021 | Feb. 28, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Subsequent Event [Line Items] |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of commissions and offering expenses |  |  |  |  |  | $ 50 | $ 144
Public Offerings |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
ATM Facility description |  |  | In July 2022, the Company completed an underwritten public offering of its common stock, warrants to purchase shares of its common stock and pre-funded warrants to purchase shares of its common stock. The Company sold 18,675,466 shares of its common stock with accompanying warrants to purchase up to 9,337,733 shares of its common stock at a combined public offering price of $3.55 per share. The Company also sold 7,944,252 pre-funded warrants to purchase shares of its common stock with accompanying warrants to purchase up to 3,972,126 shares of its common stock at a combined public offering price of $3.549 per pre-funded warrant, which represents the per share public offering price for the common stock less $0.001 per share, the exercise price for each pre-funded warrant. The Company raised net proceeds of $88.2 million, after deducting underwriting discounts and commissions of $5.7 million and other offering costs of $0.6 million. |  |  |  |
Proceeds from issuance of common stock, net of commissions and offering expenses |  |  | $ 88,200 |  |  |  |
Shares issued and sold |  |  | 18,675,466 |  |  |  |
A T M Facility |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
ATM Facility description |  |  |  |  |  | In January and February 2023, the Company received aggregate proceeds of $13.4 million, net of commissions from sales of 968,000 shares of its common stock pursuant to the ATM Facility (see Note 7). |
A T M Facility | Public Offerings | Maximum |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Maximum amount of equity shares issuable |  |  |  | $ 75,000 |  |  |
SVB Leerink LLC | Public Offerings |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of commissions and offering expenses |  |  |  |  |  | $ 28,500 | $ 3,300
Shares issued and sold |  |  |  |  |  | 3,948,611 | 186,546
Subsequent Event | 2023 Loan Agreement |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Line of credit facility, maximum borrowing capacity |  | $ 100,000 |  |  |  |  |
Debt instrument, maturity date, description |  | The term loans under the 2023 Loan Agreement mature on January 1, 2027. The maturity date may be extended to July 1, 2027, provided that the second and third tranches are funded and the Company achieves certain other financing milestones. |  |  |  |  |
Debt instrument, maturity date |  | Jan. 01, 2027 |  |  |  |  |
Debt instrument, interest rate |  | 8.45% |  |  |  |  |
Debt instrument, basis spread on variable rate |  | 2.25% |  |  |  |  |
Subsequent Event | 2021 Loan Agreement |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Total principal amount outstanding |  | $ 20,000 |  |  |  |  |
Debt instrument, final payment fee |  | 1,000 |  |  |  |  |
Debt instrument, early prepayment fee |  | 400 |  |  |  |  |
Subsequent Event | A T M Facility |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of commissions and offering expenses |  |  |  |  | $ 13,400 |  |
Shares issued and sold |  |  |  |  | 968,000 |  |
Subsequent Event | A T M Facility | Public Offerings |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Sales Agreement transaction date | Feb. 15, 2023 |  |  |  |  |  |
Subsequent Event | A T M Facility | Public Offerings | Maximum |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Maximum amount of equity shares issuable | $ 150,000 |  |  |  |  |  |
Tranche one | Subsequent Event | 2023 Loan Agreement |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Line of credit facility, maximum borrowing capacity |  | 25,000 |  |  |  |  |
Tranche one | Subsequent Event | 2021 Loan Agreement |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Loan Agreement funded outstanding amount |  | 25,000 |  |  |  |  |
Tranche two and three | Subsequent Event | 2023 Loan Agreement |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Line of credit facility, maximum borrowing capacity |  | $ 25,000 |  |  |  |  |
Debt instrument, maturity date |  | Jul. 01, 2027 |  |  |  |  |
Tranche Four | Subsequent Event | 2023 Loan Agreement |  |  |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |  |  |
Line of credit facility, maximum borrowing capacity |  | $ 50,000 |  |  |  |  |

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