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Subsequent Events - Additional Information (Details) - USD ($)
$ in Thousands
 1 Months Ended 2 Months Ended 12 Months Ended
Feb. 15, 2023
Jan. 31, 2023
Jul. 31, 2022
Mar. 31, 2021
Feb. 28, 2023
Dec. 31, 2022
Dec. 31, 2021
Subsequent Event [Line Items]              
Proceeds from issuance of common stock, net of commissions and offering expenses           $ 50 $ 144
Public Offerings              
Subsequent Event [Line Items]              
ATM Facility description     In July 2022, the Company completed an underwritten public offering of its common stock, warrants to purchase shares of its common stock and pre-funded warrants to purchase shares of its common stock. The Company sold 18,675,466 shares of its common stock with accompanying warrants to purchase up to 9,337,733 shares of its common stock at a combined public offering price of $3.55 per share. The Company also sold 7,944,252 pre-funded warrants to purchase shares of its common stock with accompanying warrants to purchase up to 3,972,126 shares of its common stock at a combined public offering price of $3.549 per pre-funded warrant, which represents the per share public offering price for the common stock less $0.001 per share, the exercise price for each pre-funded warrant. The Company raised net proceeds of $88.2 million, after deducting underwriting discounts and commissions of $5.7 million and other offering costs of $0.6 million.        
Proceeds from issuance of common stock, net of commissions and offering expenses     $ 88,200        
Shares issued and sold     18,675,466        
A T M Facility              
Subsequent Event [Line Items]              
ATM Facility description           In January and February 2023, the Company received aggregate proceeds of $13.4 million, net of commissions from sales of 968,000 shares of its common stock pursuant to the ATM Facility (see Note 7).  
A T M Facility | Public Offerings | Maximum              
Subsequent Event [Line Items]              
Maximum amount of equity shares issuable       $ 75,000      
SVB Leerink LLC | Public Offerings              
Subsequent Event [Line Items]              
Proceeds from issuance of common stock, net of commissions and offering expenses           $ 28,500 $ 3,300
Shares issued and sold           3,948,611 186,546
Subsequent Event | 2023 Loan Agreement              
Subsequent Event [Line Items]              
Line of credit facility, maximum borrowing capacity   $ 100,000          
Debt instrument, maturity date, description   The term loans under the 2023 Loan Agreement mature on January 1, 2027. The maturity date may be extended to July 1, 2027, provided that the second and third tranches are funded and the Company achieves certain other financing milestones.          
Debt instrument, maturity date   Jan. 01, 2027          
Debt instrument, interest rate   8.45%          
Debt instrument, basis spread on variable rate   2.25%          
Subsequent Event | 2021 Loan Agreement              
Subsequent Event [Line Items]              
Total principal amount outstanding   $ 20,000          
Debt instrument, final payment fee   1,000          
Debt instrument, early prepayment fee   400          
Subsequent Event | A T M Facility              
Subsequent Event [Line Items]              
Proceeds from issuance of common stock, net of commissions and offering expenses         $ 13,400    
Shares issued and sold         968,000    
Subsequent Event | A T M Facility | Public Offerings              
Subsequent Event [Line Items]              
Sales Agreement transaction date Feb. 15, 2023            
Subsequent Event | A T M Facility | Public Offerings | Maximum              
Subsequent Event [Line Items]              
Maximum amount of equity shares issuable $ 150,000            
Tranche one | Subsequent Event | 2023 Loan Agreement              
Subsequent Event [Line Items]              
Line of credit facility, maximum borrowing capacity   25,000          
Tranche one | Subsequent Event | 2021 Loan Agreement              
Subsequent Event [Line Items]              
Loan Agreement funded outstanding amount   25,000          
Tranche two and three | Subsequent Event | 2023 Loan Agreement              
Subsequent Event [Line Items]              
Line of credit facility, maximum borrowing capacity   $ 25,000          
Debt instrument, maturity date   Jul. 01, 2027          
Tranche Four | Subsequent Event | 2023 Loan Agreement              
Subsequent Event [Line Items]              
Line of credit facility, maximum borrowing capacity   $ 50,000