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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' (DEFICIT) EQUITY - USD ($) shares in Thousands, $ in Thousands | Total | Phygen, LLC [Member] | Common Stock [Member] | Common Stock [Member] Phygen, LLC [Member] | Additional paid-in capital [Member] | Additional paid-in capital [Member] Phygen, LLC [Member] | Shareholder note receivable [Member] | Treasury stock [Member] | Accumulated other comprehensive income (loss) [Member] | Accumulated deficit [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance beginning, value at Dec. 31, 2012 | $ 245,816 |  | $ 10 |  | $ 399,246 |  |  | $ (97) | $ 112 | $ (153,455)
Balance beginning, shares at Dec. 31, 2012 |  |  | 96,703 |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Stock-based compensation | 2,590 |  |  |  | 2,590 |  |  |  |  |
Exercise of stock options | 8 |  |  |  | 8 |  |  |  |  |
Exercise of stock options, shares |  |  | 6 |  |  |  |  |  |  |
Repurchase and/or forfeiture of common stock | (172) |  |  |  | (172) |  |  |  |  |
Repurchase and/or forfeiture of common stock, shares |  |  | (142) |  |  |  |  |  |  |
Shares issued for consulting services | 1,488 |  |  |  | 1,488 |  |  |  |  |
Shares issued for consulting services, shares |  |  | 354 |  |  |  |  |  |  |
Issuance of common stock in connection with license agreements | 250 |  |  |  | 250 |  |  |  |  |
Issuance of common stock in connection with license agreements, shares |  |  | 130 |  |  |  |  |  |  |
Forfeiture of common stock in connection with business acquisition |  | $ (561) |  | $ 0 |  | $ (561) |  |  |  |
Forfeiture of common stock in connection with business acquisition, shares |  |  |  | (328) |  |  |  |  |  |
Issuance of common stock for employee stock purchase plan | 719 |  |  |  | 719 |  |  |  |  |
Issuance of common stock for employee stock purchase plan, shares |  |  | 500 |  |  |  |  |  |  |
Issuance of common stock for restricted share awards granted to employees, shares |  |  | 376 |  |  |  |  |  |  |
Foreign currency translation adjustments | 3,765 |  |  |  |  |  |  |  | 3,765 |
Net loss | (82,227) |  |  |  |  |  |  |  |  | (82,227)
Balance ending, value at Dec. 31, 2013 | 171,676 |  | $ 10 |  | 403,568 |  |  | (97) | 3,877 | (235,682)
Balance ending, shares at Dec. 31, 2013 |  |  | 97,599 |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Stock-based compensation | 2,690 |  |  |  | 2,690 |  |  |  |  |
Exercise of stock options | 29 |  |  |  | 29 |  |  |  |  |
Exercise of stock options, shares |  |  | 21 |  |  |  |  |  |  |
Repurchase and/or forfeiture of common stock | (3) |  |  |  | (3) |  |  |  |  |
Repurchase and/or forfeiture of common stock, shares |  |  | (266) |  |  |  |  |  |  |
Shares issued for consulting services | 1,864 |  |  |  | 1,864 |  |  |  |  |
Shares issued for consulting services, shares |  |  | 1,327 |  |  |  |  |  |  |
Issuance of common stock for employee stock purchase plan | 671 |  |  |  | 671 |  |  |  |  |
Issuance of common stock for employee stock purchase plan, shares |  |  | 608 |  |  |  |  |  |  |
Issuance of common stock for restricted share awards granted to employees, shares |  |  | 493 |  |  |  |  |  |  |
Shareholder note receivable | 0 |  |  |  | 5,000 |  | $ (5,000) |  |  |
Issuance of common stock for acquired technology | 102 |  |  |  | 102 |  |  |  |  |
Issuance of common stock for acquired technology, shares |  |  | 74 |  |  |  |  |  |  |
Foreign currency translation adjustments | (15,193) |  |  |  |  |  |  |  | (15,193) |
Net loss | (12,882) |  |  |  |  |  |  |  |  | (12,882)
Balance ending, value at Dec. 31, 2014 | 148,954 |  | $ 10 |  | 413,921 |  | (5,000) | (97) | (11,316) | (248,564)
Balance ending, shares at Dec. 31, 2014 |  |  | 99,856 |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |
Stock-based compensation | 2,562 |  |  |  | 2,562 |  |  |  |  |
Exercise of stock options | $ 0 |  |  |  | 0 |  |  |  |  |
Exercise of stock options, shares | 5 |  | 5 |  |  |  |  |  |  |
Repurchase and/or forfeiture of common stock | $ 0 |  |  |  | 0 |  |  |  |  |
Repurchase and/or forfeiture of common stock, shares |  |  | (261) |  |  |  |  |  |  |
Shares issued for consulting services | 81 |  |  |  | 81 |  |  |  |  |
Shares issued for consulting services, shares |  |  | 1,325 |  |  |  |  |  |  |
Issuance of common stock for employee stock purchase plan | 375 |  |  |  | 375 |  |  |  |  |
Issuance of common stock for employee stock purchase plan, shares |  |  | 868 |  |  |  |  |  |  |
Issuance of common stock for restricted share awards granted to employees, shares |  |  | 292 |  |  |  |  |  |  |
Issuance of common stock for acquired technology | 0 |  |  |  | 0 |  |  |  |  |
Issuance of common stock for acquired technology, shares |  |  | 73 |  |  |  |  |  |  |
Foreign currency translation adjustments | (9,872) |  |  |  |  |  |  |  | (9,872) |
Net loss | (178,676) |  |  |  |  |  |  |  |  | (178,676)
Balance ending, value at Dec. 31, 2015 | $ (36,576) |  | $ 10 |  | $ 416,939 |  | $ (5,000) | $ (97) | $ (21,188) | $ (427,240)
Balance ending, shares at Dec. 31, 2015 |  |  | 102,158 |  |  |  |  |  |  |

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