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Equity Transactions - Additional Information (Details) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Nov. 21, 2014
Mar. 20, 2014
Mar. 20, 2014
Mar. 17, 2014
Dec. 31, 2011
Dec. 31, 2015
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Class of Warrant or Right [Line Items]                  
Other income (expense)             $ 6,980,000 $ (33,000) $ (1,662,000)
Common stock warrant liabilities           $ 687,000 $ 687,000 8,702,000  
Fair Value Assumptions and Methodology for Assets and Liabilities [Abstract]                  
Risk-free interest rate           1.30%      
Dividend yield           0.00%      
Expected volatility           70.00%      
Expected life           4 years 3 months      
Deerfield [Member]                  
Class of Warrant or Right [Line Items]                  
Number of common shares to be called by warrants           11,450,000 11,450,000    
Exercise price of warrants $ 1.39 $ 1.39 $ 1.39 $ 1.39          
Number of days following borrowing request to determine exercise price associated with each disbursement borrowing under facility agreement       15 days          
Maximum borrowing capacity       $ 50,000,000   $ 26,000,000 $ 26,000,000 $ 26,000,000  
Warrants value $ 900,000 $ 4,700,000 $ 4,700,000 $ 5,700,000          
Amount of draw down under Facility Agreement 6,000,000 20,000,000 20,000,000     $ 26,000,000 26,000,000    
Net proceeds from initial draw under Facility Agreement   19,500,000 19,500,000            
Net proceeds from draw under Facility Agreement 5,900,000                
Warrant amount reclassified as debt discount $ 200,000 $ 2,300,000 $ 2,300,000            
Other income (expense)             $ 8,000,000    
SiliconValley Bank (SVB) [Member]                  
Class of Warrant or Right [Line Items]                  
Number of common shares to be called by warrants         93,750        
Exercise price of warrants         $ 1.60        
Amendment fee amount waived         $ 200,000        
Warrant term         10 years        
Maximum [Member] | Deerfield [Member]                  
Class of Warrant or Right [Line Items]                  
Number of shares to purchase under warrants       10,000,000          
Warrants Issued on March 17, 2014 [Member] | Deerfield [Member]                  
Class of Warrant or Right [Line Items]                  
Number of common shares to be called by warrants       6,250,000          
Warrants issued on March 20, 2014 [Member] | Deerfield [Member]                  
Class of Warrant or Right [Line Items]                  
Number of common shares to be called by warrants   4,000,000 4,000,000            
Warrants Issued on November 21, 2014 [Member] | Deerfield [Member]                  
Class of Warrant or Right [Line Items]                  
Number of common shares to be called by warrants 1,200,000