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    <ACCEPTANCE-DATETIME>20210602172811
    ACCESSION NUMBER:		0001104659-21-075861
    CONFORMED SUBMISSION TYPE:	S-4/A
    PUBLIC DOCUMENT COUNT:		36
    FILED AS OF DATE:		20210602
    DATE AS OF CHANGE:		20210602

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			ENTERPRISE FINANCIAL SERVICES CORP
    		CENTRAL INDEX KEY:			0001025835
    		STANDARD INDUSTRIAL CLASSIFICATION:	STATE COMMERCIAL BANKS [6022]
    		IRS NUMBER:				431706259
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-4/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-256265
    		FILM NUMBER:		21990333

    	BUSINESS ADDRESS:
    		STREET 1:		150 NORTH MERAMEC
    		STREET 2:		150 NORTH MERAMEC
    		CITY:			CLAYTON
    		STATE:			MO
    		ZIP:			63105
    		BUSINESS PHONE:		3147255500

    	MAIL ADDRESS:
    		STREET 1:		150 NORTH MERAMEC
    		STREET 2:		150 NORTH MERAMEC
    		CITY:			CLAYTON
    		STATE:			MO
    		ZIP:			63105

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ENTERBANK HOLDINGS INC
    		DATE OF NAME CHANGE:	19961024
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    <SEQUENCE>1
    <FILENAME>tm2115647-3_s4a.htm
    <DESCRIPTION>S-4/A
    <TEXT>
    Document 1 - file: tm2115647-3_s4a.htm

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    <TYPE>EX-5.1
    <SEQUENCE>2
    <FILENAME>tm2115647d4_ex5-1.htm
    <DESCRIPTION>EXHIBIT 5.1
    <TEXT>
    Document 2 - file: tm2115647d4_ex5-1.htm

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    <TYPE>EX-8.1
    <SEQUENCE>3
    <FILENAME>tm2115647d4_ex8-1.htm
    <DESCRIPTION>EXHIBIT 8.1
    <TEXT>
    Document 3 - file: tm2115647d4_ex8-1.htm

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    <TYPE>EX-8.2
    <SEQUENCE>4
    <FILENAME>tm2115647d4_ex8-2.htm
    <DESCRIPTION>EXHIBIT 8.2
    <TEXT>
    Document 4 - file: tm2115647d4_ex8-2.htm

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    <SEQUENCE>5
    <FILENAME>tm2115647d4_ex23-1.htm
    <DESCRIPTION>EXHIBIT 23.1
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    Document 5 - file: tm2115647d4_ex23-1.htm

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    <SEQUENCE>6
    <FILENAME>tm2115647d4_ex23-2.htm
    <DESCRIPTION>EXHIBIT 23.2
    <TEXT>
    Document 6 - file: tm2115647d4_ex23-2.htm

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    <SEQUENCE>7
    <FILENAME>tm2115647d4_ex99-1.htm
    <DESCRIPTION>EXHIBIT 99.1
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    <SEQUENCE>8
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    <DESCRIPTION>EXHIBIT 99.2
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    Document 8 - file: tm2115647d4_ex99-2.htm

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    <SEQUENCE>9
    <FILENAME>tm2115647d4_ex99-3.htm
    <DESCRIPTION>EXHIBIT 99.3
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    Document 9 - file: tm2115647d4_ex99-3.htm

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    <SEQUENCE>10
    <FILENAME>tm2115647d4_ex99-4.htm
    <DESCRIPTION>EXHIBIT 99.4
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    Document 10 - file: tm2115647d4_ex99-4.htm

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    <SEQUENCE>11
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    <DESCRIPTION>GRAPHIC
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    <DESCRIPTION>GRAPHIC
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