<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:95331299-6776-4355-a2b3-1801e063261b,g:77663ab8-b782-4208-a5af-1b31fbdd9071-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.enterprisebank.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="efsc-20220930.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_2cdbf1ef-e4c6-4140-9c1d-cc4859d7d47a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_2cdbf1ef-e4c6-4140-9c1d-cc4859d7d47a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f5772b39-05c7-4bdc-b568-06b633832656" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f5772b39-05c7-4bdc-b568-06b633832656" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_efa169d2-47f7-4dce-ac82-e871c410537b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_Goodwill_efa169d2-47f7-4dce-ac82-e871c410537b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses_efe7ff45-f777-49bd-bd45-0c6a88caa4b2" xlink:href="efsc-20220930.xsd#efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses_efe7ff45-f777-49bd-bd45-0c6a88caa4b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_InterestBearingDepositsGreaterThan90Days_cb8befa0-5ca6-481f-aec7-00031f812302" xlink:href="efsc-20220930.xsd#efsc_InterestBearingDepositsGreaterThan90Days"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_efsc_InterestBearingDepositsGreaterThan90Days_cb8befa0-5ca6-481f-aec7-00031f812302" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_3db3318c-9fce-445a-9ffb-e77e295431b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsAndFederalFundsSold"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_3db3318c-9fce-445a-9ffb-e77e295431b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered_c8756b32-488a-4d63-bcc5-1023f68995f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered_c8756b32-488a-4d63-bcc5-1023f68995f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeAndLoansReceivablesHeldForSaleNetNotPartOfDisposalGroup_4aba9e6f-327a-4562-82e7-431582d53069" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradeAndLoansReceivablesHeldForSaleNetNotPartOfDisposalGroup"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_TradeAndLoansReceivablesHeldForSaleNetNotPartOfDisposalGroup_4aba9e6f-327a-4562-82e7-431582d53069" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssets_0f122d0f-69b1-4cb3-a776-5533262aed34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssets_0f122d0f-69b1-4cb3-a776-5533262aed34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInvestmentsAndSecuritiesAtCost_1593d6e5-fbb7-402e-9393-c5dc39aaf2bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherInvestmentsAndSecuritiesAtCost"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_OtherInvestmentsAndSecuritiesAtCost_1593d6e5-fbb7-402e-9393-c5dc39aaf2bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_2a733936-ae1c-4c0a-8615-2bc35570bec1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_e65a10e1-f1cd-41c9-b17d-c93eba591bc5" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_2a733936-ae1c-4c0a-8615-2bc35570bec1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_a63c20c7-338e-4718-8285-91c5c79ce83d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsAndFederalFundsSold"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_ad511dd4-0eba-47de-a79d-f7a03227a780" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_a63c20c7-338e-4718-8285-91c5c79ce83d" xlink:to="loc_us-gaap_CashAndDueFromBanks_ad511dd4-0eba-47de-a79d-f7a03227a780" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsSold_84c10323-9d3a-4d9d-9eb3-5aed5b9f1ee7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalFundsSold"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_a63c20c7-338e-4718-8285-91c5c79ce83d" xlink:to="loc_us-gaap_FederalFundsSold_84c10323-9d3a-4d9d-9eb3-5aed5b9f1ee7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositsInBanks_76e9ade7-793a-4c74-a54f-b330be81c346" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositsInBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_a63c20c7-338e-4718-8285-91c5c79ce83d" xlink:to="loc_us-gaap_InterestBearingDepositsInBanks_76e9ade7-793a-4c74-a54f-b330be81c346" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_910c88e9-84da-4b8a-9ff4-5a9b4d1d0286" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2d32bdee-a130-43c0-afd4-5ec6f092287b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_910c88e9-84da-4b8a-9ff4-5a9b4d1d0286" xlink:to="loc_us-gaap_StockholdersEquity_2d32bdee-a130-43c0-afd4-5ec6f092287b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_e6cb7196-1e33-46d9-9828-b0d1ffadd22d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_910c88e9-84da-4b8a-9ff4-5a9b4d1d0286" xlink:to="loc_us-gaap_CommitmentsAndContingencies_e6cb7196-1e33-46d9-9828-b0d1ffadd22d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_9cda7d97-cedf-4c33-9685-eae963f89edd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_910c88e9-84da-4b8a-9ff4-5a9b4d1d0286" xlink:to="loc_us-gaap_Liabilities_9cda7d97-cedf-4c33-9685-eae963f89edd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDomesticDepositDemand_88dd6cf8-6f6d-49c1-9345-c5d4419cb5e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestBearingDomesticDepositDemand"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:to="loc_us-gaap_NoninterestBearingDomesticDepositDemand_88dd6cf8-6f6d-49c1-9345-c5d4419cb5e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDomesticDepositChecking_6fc4443e-0aa6-4915-af1a-73d5a25214fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDomesticDepositChecking"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:to="loc_us-gaap_InterestBearingDomesticDepositChecking_6fc4443e-0aa6-4915-af1a-73d5a25214fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsMoneyMarketDeposits_0324f626-a687-4ef3-b3da-fe4631f8c3ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsMoneyMarketDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:to="loc_us-gaap_DepositsMoneyMarketDeposits_0324f626-a687-4ef3-b3da-fe4631f8c3ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsSavingsDeposits_e4f633f0-aa6b-4d53-926a-d00c47debd2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsSavingsDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:to="loc_us-gaap_DepositsSavingsDeposits_e4f633f0-aa6b-4d53-926a-d00c47debd2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits100000OrMore_565952d6-9082-4902-956b-41e4cb4eaa6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDeposits100000OrMore"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:to="loc_us-gaap_TimeDeposits100000OrMore_565952d6-9082-4902-956b-41e4cb4eaa6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositsAtOrAboveFDICInsuranceLimit_5647806a-ebfb-4668-8c15-7d7991f801c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositsAtOrAboveFDICInsuranceLimit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cee55419-f0a5-41fd-8567-f8d59add5030" xlink:to="loc_us-gaap_TimeDepositsAtOrAboveFDICInsuranceLimit_5647806a-ebfb-4668-8c15-7d7991f801c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered_65e89699-59df-4eb2-a5a8-28aa45f0e322" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableGrossCarryingAmount_a6049c08-7b08-47e7-9dc0-d9c378ed381f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableGrossCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered_65e89699-59df-4eb2-a5a8-28aa45f0e322" xlink:to="loc_us-gaap_LoansAndLeasesReceivableGrossCarryingAmount_a6049c08-7b08-47e7-9dc0-d9c378ed381f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableAllowance_33756fb0-bfb8-4be8-9ee2-d644a5a24627" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmountCoveredAndNotCovered_65e89699-59df-4eb2-a5a8-28aa45f0e322" xlink:to="loc_us-gaap_LoansAndLeasesReceivableAllowance_33756fb0-bfb8-4be8-9ee2-d644a5a24627" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_377f1f82-c9e0-4cd9-8112-e0d768048ae2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_4601f6a5-0acd-4ae4-81e7-98b8cbc815a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_377f1f82-c9e0-4cd9-8112-e0d768048ae2" xlink:to="loc_us-gaap_Deposits_4601f6a5-0acd-4ae4-81e7-98b8cbc815a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesLongTerm_29922c84-431a-4bbc-88f4-b7b37ae1286f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesLongTerm"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_377f1f82-c9e0-4cd9-8112-e0d768048ae2" xlink:to="loc_us-gaap_FederalHomeLoanBankAdvancesLongTerm_29922c84-431a-4bbc-88f4-b7b37ae1286f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherBorrowings_b6885387-c9d5-4772-ace6-af2ee46f559e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_377f1f82-c9e0-4cd9-8112-e0d768048ae2" xlink:to="loc_us-gaap_OtherBorrowings_b6885387-c9d5-4772-ace6-af2ee46f559e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedDebt_96fcfd4b-24b1-4028-9e19-5ba59b743a03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubordinatedDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_377f1f82-c9e0-4cd9-8112-e0d768048ae2" xlink:to="loc_us-gaap_SubordinatedDebt_96fcfd4b-24b1-4028-9e19-5ba59b743a03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_eec615f1-4006-4b5c-91b8-e443644485b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_377f1f82-c9e0-4cd9-8112-e0d768048ae2" xlink:to="loc_us-gaap_OtherLiabilities_eec615f1-4006-4b5c-91b8-e443644485b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_deee0f07-fc51-4b23-beb5-bea85938f797" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:to="loc_us-gaap_PreferredStockValue_deee0f07-fc51-4b23-beb5-bea85938f797" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_5f6d954a-c040-4cf5-a167-131728a63fa2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:to="loc_us-gaap_CommonStockValue_5f6d954a-c040-4cf5-a167-131728a63fa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_b63736bf-c004-499b-af1a-73eb18075d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:to="loc_us-gaap_TreasuryStockValue_b63736bf-c004-499b-af1a-73eb18075d2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_22feee57-98f5-4eaa-b8a8-a394b4cc7b5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:to="loc_us-gaap_AdditionalPaidInCapital_22feee57-98f5-4eaa-b8a8-a394b4cc7b5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b796f2fc-17c7-4611-befd-36317a445244" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b796f2fc-17c7-4611-befd-36317a445244" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b661a4a7-f647-4231-927c-b56408ebf3b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_3dcb115d-ddc9-49a8-9477-b4c9ceba1554" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b661a4a7-f647-4231-927c-b56408ebf3b1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="efsc-20220930.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_367dc779-e98c-41f2-b7f6-2c0169357169" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_44075f56-c4bd-4b11-b1b4-9a8f1da8fe88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_367dc779-e98c-41f2-b7f6-2c0169357169" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_44075f56-c4bd-4b11-b1b4-9a8f1da8fe88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_6250d2f9-d1d5-4f8f-944f-7bbebe6e3bc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_367dc779-e98c-41f2-b7f6-2c0169357169" xlink:to="loc_us-gaap_InterestExpense_6250d2f9-d1d5-4f8f-944f-7bbebe6e3bc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_22d0feaf-7ea1-4647-a0dd-0175419072ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d798a909-e809-4571-a671-26fc0da977e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_22d0feaf-7ea1-4647-a0dd-0175419072ce" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d798a909-e809-4571-a671-26fc0da977e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_9cb7f957-839c-4d3d-9612-f06965cd040a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_22d0feaf-7ea1-4647-a0dd-0175419072ce" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_9cb7f957-839c-4d3d-9612-f06965cd040a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_20466098-c572-4991-a627-0a173fd6f52f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfessionalFees"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_us-gaap_ProfessionalFees_20466098-c572-4991-a627-0a173fd6f52f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_MergerRelatedExpenses_5859db2e-3288-4855-a82b-79d4836ae3bd" xlink:href="efsc-20220930.xsd#efsc_MergerRelatedExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_efsc_MergerRelatedExpenses_5859db2e-3288-4855-a82b-79d4836ae3bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_ec89398b-2d52-488a-b31a-582008adcbae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_us-gaap_LaborAndRelatedExpense_ec89398b-2d52-488a-b31a-582008adcbae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_BranchClosureExpenses_09a10a65-fa1a-44c6-858b-65a83e7a9e8b" xlink:href="efsc-20220930.xsd#efsc_BranchClosureExpenses"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_efsc_BranchClosureExpenses_09a10a65-fa1a-44c6-858b-65a83e7a9e8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_547a6d13-ec0d-4c39-9c88-48b9b704598e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_us-gaap_OtherNoninterestExpense_547a6d13-ec0d-4c39-9c88-48b9b704598e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_a322d0ab-7ffd-4ada-bd94-03f6255fb842" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_a322d0ab-7ffd-4ada-bd94-03f6255fb842" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_3b1073c9-901c-407e-ba34-438797bf8b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_d941c916-4d88-49ba-99b9-057f618a5996" xlink:to="loc_us-gaap_OccupancyNet_3b1073c9-901c-407e-ba34-438797bf8b2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_fd66dd13-80f9-44de-9dce-ce8b8ee38ebb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_fcd376df-a4ad-49d1-8002-7d9958cb612e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_fd66dd13-80f9-44de-9dce-ce8b8ee38ebb" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_fcd376df-a4ad-49d1-8002-7d9958cb612e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_ProvisionForLoanLossesNotCoveredUnderFdicLossShare_b2d84fe3-27b5-4b12-884c-d925e418f0f6" xlink:href="efsc-20220930.xsd#efsc_ProvisionForLoanLossesNotCoveredUnderFdicLossShare"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_fd66dd13-80f9-44de-9dce-ce8b8ee38ebb" xlink:to="loc_efsc_ProvisionForLoanLossesNotCoveredUnderFdicLossShare_b2d84fe3-27b5-4b12-884c-d925e418f0f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_116401df-ea3e-4c84-b3d8-1ee76ea48963" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_de3e2657-91e7-4825-a25f-78c3e09d2600" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_116401df-ea3e-4c84-b3d8-1ee76ea48963" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_de3e2657-91e7-4825-a25f-78c3e09d2600" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_960dc183-3e94-4213-8c53-dce7da5f173b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_116401df-ea3e-4c84-b3d8-1ee76ea48963" xlink:to="loc_us-gaap_NoninterestIncome_960dc183-3e94-4213-8c53-dce7da5f173b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_8c26303b-9f64-4bfd-adb9-1d0feb722b94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_116401df-ea3e-4c84-b3d8-1ee76ea48963" xlink:to="loc_us-gaap_NoninterestExpense_8c26303b-9f64-4bfd-adb9-1d0feb722b94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_ee401ec4-aef4-4a9f-a306-f7428355e982" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_90a90eab-4714-4eab-abfa-ba0f8bb5417a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_ee401ec4-aef4-4a9f-a306-f7428355e982" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_90a90eab-4714-4eab-abfa-ba0f8bb5417a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxable_ce4171f7-ffb3-4fd9-8c5c-9bce0f871b68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_ee401ec4-aef4-4a9f-a306-f7428355e982" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxable_ce4171f7-ffb3-4fd9-8c5c-9bce0f871b68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_07194bd0-5563-4767-b34b-b9b52146786f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeSecuritiesTaxExempt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_ee401ec4-aef4-4a9f-a306-f7428355e982" xlink:to="loc_us-gaap_InterestIncomeSecuritiesTaxExempt_07194bd0-5563-4767-b34b-b9b52146786f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeDomesticDeposits_eaaf38a8-5a60-4703-a0d1-cef31cad2f36" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeDomesticDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_ee401ec4-aef4-4a9f-a306-f7428355e982" xlink:to="loc_us-gaap_InterestIncomeDomesticDeposits_eaaf38a8-5a60-4703-a0d1-cef31cad2f36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendIncomeOperating_fe9179fd-48d9-445e-ac9d-18a17cbaf547" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendIncomeOperating"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_ee401ec4-aef4-4a9f-a306-f7428355e982" xlink:to="loc_us-gaap_DividendIncomeOperating_fe9179fd-48d9-445e-ac9d-18a17cbaf547" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_bba39781-8e6e-4faa-9502-a5cf603d5e92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_70b4055d-3cd2-4c64-830a-1149c92bf539" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseSubordinatedNotesAndDebentures"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_bba39781-8e6e-4faa-9502-a5cf603d5e92" xlink:to="loc_us-gaap_InterestExpenseSubordinatedNotesAndDebentures_70b4055d-3cd2-4c64-830a-1149c92bf539" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm_f1063911-6fa1-45e4-a3f6-18434a0c509d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_bba39781-8e6e-4faa-9502-a5cf603d5e92" xlink:to="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm_f1063911-6fa1-45e4-a3f6-18434a0c509d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_50f312c5-7865-41f3-ab4d-bc3caa420558" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_bba39781-8e6e-4faa-9502-a5cf603d5e92" xlink:to="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_50f312c5-7865-41f3-ab4d-bc3caa420558" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_9181f4c1-9c4e-43e0-93b9-b78620211b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_bba39781-8e6e-4faa-9502-a5cf603d5e92" xlink:to="loc_us-gaap_InterestExpenseDeposits_9181f4c1-9c4e-43e0-93b9-b78620211b7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_427566e4-4a40-4965-93fa-14daf234f9d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments_d9fcab91-e878-4ac8-9107-852a916565da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockDividendsAndOtherAdjustments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_427566e4-4a40-4965-93fa-14daf234f9d8" xlink:to="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments_d9fcab91-e878-4ac8-9107-852a916565da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_34277330-620a-4dce-8640-d4229bc071d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_427566e4-4a40-4965-93fa-14daf234f9d8" xlink:to="loc_us-gaap_NetIncomeLoss_34277330-620a-4dce-8640-d4229bc071d2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="efsc-20220930.xsd#CondensedConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/CondensedConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df27f78a-384d-42e3-b4c5-0bf71fbbb7e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments_5239b1bb-f949-4be2-803a-f962f72c9f84" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df27f78a-384d-42e3-b4c5-0bf71fbbb7e0" xlink:to="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments_5239b1bb-f949-4be2-803a-f962f72c9f84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_9e9f37a7-61a3-4360-bc4b-1c72067ea3d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df27f78a-384d-42e3-b4c5-0bf71fbbb7e0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_9e9f37a7-61a3-4360-bc4b-1c72067ea3d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_13c40f35-b0a7-47f4-aabc-ad4aae2df14e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df27f78a-384d-42e3-b4c5-0bf71fbbb7e0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_13c40f35-b0a7-47f4-aabc-ad4aae2df14e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_d5719caf-c880-4876-90c8-6c2cbbe98686" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df27f78a-384d-42e3-b4c5-0bf71fbbb7e0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_d5719caf-c880-4876-90c8-6c2cbbe98686" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d171c88e-434b-421a-aa2c-107192bb8e01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_592b535a-e040-4ebb-ac48-cfbf041b234b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_d171c88e-434b-421a-aa2c-107192bb8e01" xlink:to="loc_us-gaap_NetIncomeLoss_592b535a-e040-4ebb-ac48-cfbf041b234b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5f79e3ac-2a43-49ed-8aed-ad2604cc80a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_d171c88e-434b-421a-aa2c-107192bb8e01" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5f79e3ac-2a43-49ed-8aed-ad2604cc80a1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="efsc-20220930.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_55897714-1237-4e16-8fc6-39fcf8eb6953" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_55897714-1237-4e16-8fc6-39fcf8eb6953" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_RepaymentsOfLongTermFederalHomeLoanBankAdvances_41ec5e61-eaba-4823-9f1f-7511bb07935e" xlink:href="efsc-20220930.xsd#efsc_RepaymentsOfLongTermFederalHomeLoanBankAdvances"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_efsc_RepaymentsOfLongTermFederalHomeLoanBankAdvances_41ec5e61-eaba-4823-9f1f-7511bb07935e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_a3612a06-49de-4950-94eb-fa20fe61e37f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_a3612a06-49de-4950-94eb-fa20fe61e37f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_8c02626c-2bd7-43a9-9a3c-4f9359e5c6c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_8c02626c-2bd7-43a9-9a3c-4f9359e5c6c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForInSecuritiesSoldUnderAgreementsToRepurchase_a7065276-3229-4aba-b1b2-f5401ab4d11d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForInSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_ProceedsFromPaymentsForInSecuritiesSoldUnderAgreementsToRepurchase_a7065276-3229-4aba-b1b2-f5401ab4d11d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_ProceedsfromPaymentsforShortTermFHLBankBorrowingsFinancingActivities_1f35079f-3447-4a1e-8fcc-f1382c78c400" xlink:href="efsc-20220930.xsd#efsc_ProceedsfromPaymentsforShortTermFHLBankBorrowingsFinancingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_efsc_ProceedsfromPaymentsforShortTermFHLBankBorrowingsFinancingActivities_1f35079f-3447-4a1e-8fcc-f1382c78c400" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetChangeInterestBearingDepositsDomestic_023a4eeb-262e-4392-859c-7fd2d28cbf97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetChangeInterestBearingDepositsDomestic"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_NetChangeInterestBearingDepositsDomestic_023a4eeb-262e-4392-859c-7fd2d28cbf97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_de4ff908-1dfb-494a-a86b-e70ba0577b79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_de4ff908-1dfb-494a-a86b-e70ba0577b79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_952e7111-86e8-480a-b90d-bfabdef0af0d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_952e7111-86e8-480a-b90d-bfabdef0af0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetChangeNoninterestBearingDepositsDomestic_7957d5c7-b367-446a-ae3c-8279388ef7d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetChangeNoninterestBearingDepositsDomestic"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65563001-f9c1-49d2-ab31-f126f2183e47" xlink:to="loc_us-gaap_NetChangeNoninterestBearingDepositsDomestic_7957d5c7-b367-446a-ae3c-8279388ef7d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_PaymentsToAcquireStateTaxCreditsHeldForSale_cfc36208-6961-45f8-b42e-95ba6b1455c4" xlink:href="efsc-20220930.xsd#efsc_PaymentsToAcquireStateTaxCreditsHeldForSale"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_efsc_PaymentsToAcquireStateTaxCreditsHeldForSale_cfc36208-6961-45f8-b42e-95ba6b1455c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfOtherRealEstate_8fb192aa-e35e-4c84-9b67-0df54fa54563" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfOtherRealEstate"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromSaleOfOtherRealEstate_8fb192aa-e35e-4c84-9b67-0df54fa54563" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_3f7a86d2-0a53-432d-9bb5-ef78e4187af3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_3f7a86d2-0a53-432d-9bb5-ef78e4187af3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_1964d218-64b8-40bd-8ae2-51d52e26e923" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_1964d218-64b8-40bd-8ae2-51d52e26e923" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_2fc01972-3958-45ae-ac5d-5ac18cb1fef6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_2fc01972-3958-45ae-ac5d-5ac18cb1fef6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfOtherInvestments_60c0364f-8e2f-48d4-9f99-de68cdf6f60b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfOtherInvestments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfOtherInvestments_60c0364f-8e2f-48d4-9f99-de68cdf6f60b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLifeInsurancePolicies_966e2d1b-0a46-477a-b310-72fdb953b763" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromLifeInsurancePolicies"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromLifeInsurancePolicies_966e2d1b-0a46-477a-b310-72fdb953b763" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_4aa65513-5ac6-4442-9e1d-f4ab29b5736d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_4aa65513-5ac6-4442-9e1d-f4ab29b5736d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_4d8e5607-3b02-46b3-b3e8-877fe32c02d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_4d8e5607-3b02-46b3-b3e8-877fe32c02d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_cda9e9ab-1239-4a68-9a97-051f5f637aed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_cda9e9ab-1239-4a68-9a97-051f5f637aed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_ProceedsFromSaleOfStateTaxCreditsHeldForSale_95a70711-74e6-4c0a-ba00-4536a9cba72b" xlink:href="efsc-20220930.xsd#efsc_ProceedsFromSaleOfStateTaxCreditsHeldForSale"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_efsc_ProceedsFromSaleOfStateTaxCreditsHeldForSale_95a70711-74e6-4c0a-ba00-4536a9cba72b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_e86c01ed-92ec-40f3-921e-517e00bd896b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_e86c01ed-92ec-40f3-921e-517e00bd896b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_ac67c896-6a9e-4665-94f3-f0b23249b917" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromLoansAndLeases"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_ac67c896-6a9e-4665-94f3-f0b23249b917" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities_2c6e2681-c5a8-4ab6-a30d-bba6e981f337" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities_2c6e2681-c5a8-4ab6-a30d-bba6e981f337" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates_fc071dce-deef-4ef0-adaf-a49a3ce1a28a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a655ff44-afcc-42ec-bd4a-3bfac71502d5" xlink:to="loc_us-gaap_PaymentsForProceedsFromBusinessesAndInterestInAffiliates_fc071dce-deef-4ef0-adaf-a49a3ce1a28a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_cc81a2c0-77bc-432d-ad63-ee499ee042c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_cc81a2c0-77bc-432d-ad63-ee499ee042c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_d70c5d72-e92f-4255-9ef8-2de3b8abea87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_AssetImpairmentCharges_d70c5d72-e92f-4255-9ef8-2de3b8abea87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanAndLeaseLosses_d883101a-a7eb-4f70-ad9c-f857a280efcf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanAndLeaseLosses"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_ProvisionForLoanAndLeaseLosses_d883101a-a7eb-4f70-ad9c-f857a280efcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_a40c2ff7-dbb9-45e4-b7ba-ef5ad795adb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_PaymentsForOriginationOfMortgageLoansHeldForSale_a40c2ff7-dbb9-45e4-b7ba-ef5ad795adb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_c0f43be5-5fd3-4ef2-b0f6-6ce46fb5207b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_c0f43be5-5fd3-4ef2-b0f6-6ce46fb5207b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_32ededa1-6a64-4f7c-a5c1-f70d90b06794" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_ProceedsFromSaleOfMortgageLoansHeldForSale_32ededa1-6a64-4f7c-a5c1-f70d90b06794" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_897030e9-abbb-4074-9815-4bd439b34181" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_897030e9-abbb-4074-9815-4bd439b34181" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_1b8f4a88-a6e2-4f01-b6cb-249e409e0f37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_ShareBasedCompensation_1b8f4a88-a6e2-4f01-b6cb-249e409e0f37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2a929c89-9b03-45a8-a9ee-368832be727e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_NetIncomeLoss_2a929c89-9b03-45a8-a9ee-368832be727e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationNonproduction_abc07be8-4690-4912-9d22-930507f3e57a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationNonproduction"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_DepreciationNonproduction_abc07be8-4690-4912-9d22-930507f3e57a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_NetAccretionOfLoanDiscountAndIndemnificationAsset_c0f5e337-7354-4819-ac7f-aca502ea4103" xlink:href="efsc-20220930.xsd#efsc_NetAccretionOfLoanDiscountAndIndemnificationAsset"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_efsc_NetAccretionOfLoanDiscountAndIndemnificationAsset_c0f5e337-7354-4819-ac7f-aca502ea4103" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_e6dbf4d2-2bb7-4611-aa15-8135ddc05f85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_e6dbf4d2-2bb7-4611-aa15-8135ddc05f85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_29995688-cc4f-4378-9086-b1bfca6f8161" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_29995688-cc4f-4378-9086-b1bfca6f8161" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_AmortizationOfServicingAssets_6e4b2fb1-8ede-4a4b-99bc-fde2e3e26c89" xlink:href="efsc-20220930.xsd#efsc_AmortizationOfServicingAssets"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_efsc_AmortizationOfServicingAssets_6e4b2fb1-8ede-4a4b-99bc-fde2e3e26c89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_GainOnStateTaxCreditsNet_81fa9242-0185-461d-9cd2-531f923572d3" xlink:href="efsc-20220930.xsd#efsc_GainOnStateTaxCreditsNet"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_efsc_GainOnStateTaxCreditsNet_81fa9242-0185-461d-9cd2-531f923572d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfProperties_969273ab-b853-45e3-8df0-1a3fe996f9a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfProperties"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f06f75c5-4c37-4e1d-b88a-31681e70ab6d" xlink:to="loc_us-gaap_GainLossOnSaleOfProperties_969273ab-b853-45e3-8df0-1a3fe996f9a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_263a3645-21e5-4db8-b094-f288bf5b2692" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_706a480b-3bdb-437b-a5c9-55cfc59f2c3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_263a3645-21e5-4db8-b094-f288bf5b2692" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_706a480b-3bdb-437b-a5c9-55cfc59f2c3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d3982312-37a8-4a7c-a9b4-17a75e633aa2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_263a3645-21e5-4db8-b094-f288bf5b2692" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d3982312-37a8-4a7c-a9b4-17a75e633aa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d19202fd-eaa0-4f8a-a202-f00c23bf221b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_263a3645-21e5-4db8-b094-f288bf5b2692" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d19202fd-eaa0-4f8a-a202-f00c23bf221b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e4d3d0a5-74ea-4cf3-b0e8-5576c55f0414" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2a6cb291-f14b-47b2-84bf-2c22b7c9b96f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e4d3d0a5-74ea-4cf3-b0e8-5576c55f0414" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2a6cb291-f14b-47b2-84bf-2c22b7c9b96f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_IncrementalCommonSharesAttributableToAdditionalDilutiveCommonStockEquivalents_d59dd0f3-e5c9-45b1-a97f-cd0170df3263" xlink:href="efsc-20220930.xsd#efsc_IncrementalCommonSharesAttributableToAdditionalDilutiveCommonStockEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e4d3d0a5-74ea-4cf3-b0e8-5576c55f0414" xlink:to="loc_efsc_IncrementalCommonSharesAttributableToAdditionalDilutiveCommonStockEquivalents_d59dd0f3-e5c9-45b1-a97f-cd0170df3263" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/InvestmentsScheduleofAvailableforsaleandHeldtoMaturitySecuritiesReconciliationDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#InvestmentsScheduleofAvailableforsaleandHeldtoMaturitySecuritiesReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/InvestmentsScheduleofAvailableforsaleandHeldtoMaturitySecuritiesReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f09af3d1-4437-4bf1-8b12-9b5de96d1897" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_bf78d6af-3c96-4064-bf5d-dd7659a273e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f09af3d1-4437-4bf1-8b12-9b5de96d1897" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_bf78d6af-3c96-4064-bf5d-dd7659a273e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d84bcd34-63d7-415e-a720-bd049d3e12a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f09af3d1-4437-4bf1-8b12-9b5de96d1897" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d84bcd34-63d7-415e-a720-bd049d3e12a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_979ce704-72c6-4943-8e1f-fa85b2a36496" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f09af3d1-4437-4bf1-8b12-9b5de96d1897" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_979ce704-72c6-4943-8e1f-fa85b2a36496" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_e9c65d3f-e112-4907-9422-39c53b2c8451" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_a55c55b3-a828-4855-b318-7e26c6bede1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e9c65d3f-e112-4907-9422-39c53b2c8451" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_a55c55b3-a828-4855-b318-7e26c6bede1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_878921a2-4a79-441c-953f-697a1e6c6224" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e9c65d3f-e112-4907-9422-39c53b2c8451" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_878921a2-4a79-441c-953f-697a1e6c6224" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_8b9ae733-44b8-456e-bbb3-635a992eab69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e9c65d3f-e112-4907-9422-39c53b2c8451" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesFairValue_8b9ae733-44b8-456e-bbb3-635a992eab69" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/InvestmentsInvestmentsClassifiedbyContractualMaturityDateDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#InvestmentsInvestmentsClassifiedbyContractualMaturityDateDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/InvestmentsInvestmentsClassifiedbyContractualMaturityDateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecurities_e471d75f-0a12-4411-b7aa-92d15591f134" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_fa5b9a10-2d1c-4565-87b5-fb6374ccf19c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e471d75f-0a12-4411-b7aa-92d15591f134" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_fa5b9a10-2d1c-4565-87b5-fb6374ccf19c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_222a2f46-805b-4ebd-9956-62cef68499af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e471d75f-0a12-4411-b7aa-92d15591f134" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_222a2f46-805b-4ebd-9956-62cef68499af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_1c0b46dc-9a35-4b0d-9525-bdcf8974744b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e471d75f-0a12-4411-b7aa-92d15591f134" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_1c0b46dc-9a35-4b0d-9525-bdcf8974744b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_211fab78-4299-4728-bac1-1bd7b5dad6f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e471d75f-0a12-4411-b7aa-92d15591f134" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_211fab78-4299-4728-bac1-1bd7b5dad6f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_e7a67abe-fd74-4ae9-93b9-34e28c16e2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecurities_e471d75f-0a12-4411-b7aa-92d15591f134" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_e7a67abe-fd74-4ae9-93b9-34e28c16e2b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_86341ea3-07b5-4210-a5ba-27df2cc2062d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_5aca150b-9d36-4031-8be2-8264068ca0a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_86341ea3-07b5-4210-a5ba-27df2cc2062d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_5aca150b-9d36-4031-8be2-8264068ca0a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_ceab55ad-b6d2-404a-86d0-bc64bfef1b59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_86341ea3-07b5-4210-a5ba-27df2cc2062d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_ceab55ad-b6d2-404a-86d0-bc64bfef1b59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_863602a2-28e4-44a7-861c-15484fe4965c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_86341ea3-07b5-4210-a5ba-27df2cc2062d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_863602a2-28e4-44a7-861c-15484fe4965c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_652e113a-932a-4fcc-882e-7cb7ec43d343" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_86341ea3-07b5-4210-a5ba-27df2cc2062d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_652e113a-932a-4fcc-882e-7cb7ec43d343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_9b676226-a10a-4b45-a9f5-08978692c0cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_86341ea3-07b5-4210-a5ba-27df2cc2062d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_9b676226-a10a-4b45-a9f5-08978692c0cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_bb6835f9-5f73-4ae4-8a40-95911a819c3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_9282262c-4333-46fd-ad5c-7758cc6af018" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_bb6835f9-5f73-4ae4-8a40-95911a819c3c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_9282262c-4333-46fd-ad5c-7758cc6af018" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_1163e4cc-a62b-45ba-a54a-6e1a60bf2c95" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_bb6835f9-5f73-4ae4-8a40-95911a819c3c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_1163e4cc-a62b-45ba-a54a-6e1a60bf2c95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_8a4a792b-e425-4030-84ab-c2883cf2db1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_bb6835f9-5f73-4ae4-8a40-95911a819c3c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_8a4a792b-e425-4030-84ab-c2883cf2db1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_9dd050c3-9c86-44fe-a760-465dd1150189" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_bb6835f9-5f73-4ae4-8a40-95911a819c3c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_9dd050c3-9c86-44fe-a760-465dd1150189" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_5b225fc6-027c-4bc9-9073-b0278303aaf1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_bb6835f9-5f73-4ae4-8a40-95911a819c3c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_5b225fc6-027c-4bc9-9073-b0278303aaf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesFairValue_56650d48-14bb-4077-88d9-47109e42c105" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_384f52c3-b48b-4125-824a-1b6e635dcfa4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_56650d48-14bb-4077-88d9-47109e42c105" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_384f52c3-b48b-4125-824a-1b6e635dcfa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_cdaeacca-27c5-41a4-90c4-92154e5663e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_56650d48-14bb-4077-88d9-47109e42c105" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_cdaeacca-27c5-41a4-90c4-92154e5663e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_a9e7caf5-1409-497c-98d7-88041441411c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_56650d48-14bb-4077-88d9-47109e42c105" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_a9e7caf5-1409-497c-98d7-88041441411c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_00301ee2-138d-4cee-bab3-8d76cd2d53bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_56650d48-14bb-4077-88d9-47109e42c105" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_00301ee2-138d-4cee-bab3-8d76cd2d53bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_ac822e03-5980-428f-a96b-02af25d88d8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_HeldToMaturitySecuritiesFairValue_56650d48-14bb-4077-88d9-47109e42c105" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_ac822e03-5980-428f-a96b-02af25d88d8e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/InvestmentsScheduleofUnrealizedLossonInvestmentsDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#InvestmentsScheduleofUnrealizedLossonInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/InvestmentsScheduleofUnrealizedLossonInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_8c51e15b-2dfe-4b54-9e21-2e04bc4dc8ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_ae4a6afa-a0b1-4786-88b0-c069df7017b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_8c51e15b-2dfe-4b54-9e21-2e04bc4dc8ee" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_ae4a6afa-a0b1-4786-88b0-c069df7017b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_cf035bcd-bdf0-489e-9a6d-db11db343391" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_8c51e15b-2dfe-4b54-9e21-2e04bc4dc8ee" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_cf035bcd-bdf0-489e-9a6d-db11db343391" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_77c6dfd3-e314-42fa-b24a-dbacbe2ac4f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_5898acb9-edad-41e5-bcd7-202267e93d37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_77c6dfd3-e314-42fa-b24a-dbacbe2ac4f4" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_5898acb9-edad-41e5-bcd7-202267e93d37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_1b9c9c0e-d819-4e71-9491-b19b1815204d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_77c6dfd3-e314-42fa-b24a-dbacbe2ac4f4" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_1b9c9c0e-d819-4e71-9491-b19b1815204d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/LoansSummaryofPortfolioLoansbyCategoryDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#LoansSummaryofPortfolioLoansbyCategoryDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/LoansSummaryofPortfolioLoansbyCategoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableCoveredAfterAllowanceForCreditLoss_29bda8ec-f8c4-4c9b-ae40-cda46becc2f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableCoveredAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedLoanCommitmentAndOriginationFeesAndUnamortizedDiscountsOrPremiums_61e9df3f-4e83-4f78-bfd9-dc0d41c42d25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnamortizedLoanCommitmentAndOriginationFeesAndUnamortizedDiscountsOrPremiums"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableCoveredAfterAllowanceForCreditLoss_29bda8ec-f8c4-4c9b-ae40-cda46becc2f4" xlink:to="loc_us-gaap_UnamortizedLoanCommitmentAndOriginationFeesAndUnamortizedDiscountsOrPremiums_61e9df3f-4e83-4f78-bfd9-dc0d41c42d25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_20d63001-bc43-46a8-9801-aa9f6994766e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinancingReceivableCoveredAfterAllowanceForCreditLoss_29bda8ec-f8c4-4c9b-ae40-cda46becc2f4" xlink:to="loc_us-gaap_NotesReceivableGross_20d63001-bc43-46a8-9801-aa9f6994766e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/LoansSummaryofTermLoansbyOriginationYearDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#LoansSummaryofTermLoansbyOriginationYearDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/LoansSummaryofTermLoansbyOriginationYearDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_FinancingReceivableConverted_4615d18f-0914-469b-aa1f-ce4988fec46c" xlink:href="efsc-20220930.xsd#efsc_FinancingReceivableConverted"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_efsc_FinancingReceivableConverted_4615d18f-0914-469b-aa1f-ce4988fec46c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRevolving_7bc90e60-53d5-4806-9554-7e8aa0026869" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableRevolving"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_us-gaap_FinancingReceivableRevolving_7bc90e60-53d5-4806-9554-7e8aa0026869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedTwoYearsBeforeLatestFiscalYear_f3f7e0a1-5804-4c0f-a030-49ed2f6c2cf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableOriginatedTwoYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_us-gaap_FinancingReceivableOriginatedTwoYearsBeforeLatestFiscalYear_f3f7e0a1-5804-4c0f-a030-49ed2f6c2cf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedThreeYearsBeforeLatestFiscalYear_567dfd02-72f3-4190-afa2-c74ac2e3b09e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableOriginatedThreeYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_us-gaap_FinancingReceivableOriginatedThreeYearsBeforeLatestFiscalYear_567dfd02-72f3-4190-afa2-c74ac2e3b09e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_FinancingReceivableOriginatedMoreThanSixYearsBeforeCurrentFiscalYear_6acce326-01d7-40ba-984f-fe8757e35956" xlink:href="efsc-20220930.xsd#efsc_FinancingReceivableOriginatedMoreThanSixYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_efsc_FinancingReceivableOriginatedMoreThanSixYearsBeforeCurrentFiscalYear_6acce326-01d7-40ba-984f-fe8757e35956" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_FinancingReceivableYearSixOriginatedFiveYearsBeforeCurrentFiscalYear_6d86c0ab-e9e9-4453-8726-4c7fdd34362f" xlink:href="efsc-20220930.xsd#efsc_FinancingReceivableYearSixOriginatedFiveYearsBeforeCurrentFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_efsc_FinancingReceivableYearSixOriginatedFiveYearsBeforeCurrentFiscalYear_6d86c0ab-e9e9-4453-8726-4c7fdd34362f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedInFiscalYearBeforeLatestFiscalYear_e98aaada-f41b-452d-9b2e-56af13d52445" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableOriginatedInFiscalYearBeforeLatestFiscalYear"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_us-gaap_FinancingReceivableOriginatedInFiscalYearBeforeLatestFiscalYear_e98aaada-f41b-452d-9b2e-56af13d52445" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedFourYearsBeforeLatestFiscalYear_5029d4e8-d8b3-4767-8957-626da597e55b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableOriginatedFourYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_f9627a5a-d0a9-4eea-867d-762f0d0de847" xlink:to="loc_us-gaap_FinancingReceivableOriginatedFourYearsBeforeLatestFiscalYear_5029d4e8-d8b3-4767-8957-626da597e55b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/DerivativeFinancialInstrumentsDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#DerivativeFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/DerivativeFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_7f177e56-a53e-4a1e-91a2-39c2ccd06018" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimCash_931d8f17-8d0e-45ec-88da-4c01bd8920d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimCash"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_7f177e56-a53e-4a1e-91a2-39c2ccd06018" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimCash_931d8f17-8d0e-45ec-88da-4c01bd8920d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimSecurities_31810389-4d73-4779-b1aa-0726c69791c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_7f177e56-a53e-4a1e-91a2-39c2ccd06018" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimSecurities_31810389-4d73-4779-b1aa-0726c69791c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_b750da67-cd17-4b08-86b9-51b80b2d157a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_7f177e56-a53e-4a1e-91a2-39c2ccd06018" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_b750da67-cd17-4b08-86b9-51b80b2d157a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_91b9d154-d8c9-4f4a-ba83-db90037e9798" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossLiability_8626c346-e39a-4dd6-8220-8dc6c71197f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossLiability"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_91b9d154-d8c9-4f4a-ba83-db90037e9798" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossLiability_8626c346-e39a-4dd6-8220-8dc6c71197f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_03e4ad71-da96-40d5-8881-9c8e8ab33e16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_91b9d154-d8c9-4f4a-ba83-db90037e9798" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_03e4ad71-da96-40d5-8881-9c8e8ab33e16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_079c5ffd-1805-474a-a250-4a2e5e8cb02f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset_47168a85-9f58-4198-92f1-3ffd4aa0ca0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_079c5ffd-1805-474a-a250-4a2e5e8cb02f" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset_47168a85-9f58-4198-92f1-3ffd4aa0ca0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseGross_9c15d1b0-7913-4a94-8bc0-430418ad6c0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_079c5ffd-1805-474a-a250-4a2e5e8cb02f" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseGross_9c15d1b0-7913-4a94-8bc0-430418ad6c0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_65222cf5-a01a-4ef2-8ac0-1d86716ffb0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_4c78e03e-2153-460e-9a4a-9fb2e75eca5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_65222cf5-a01a-4ef2-8ac0-1d86716ffb0a" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_4c78e03e-2153-460e-9a4a-9fb2e75eca5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_262bc7a9-cc64-4172-a48c-d512a84e4b53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeCollateralRightToReclaimSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_65222cf5-a01a-4ef2-8ac0-1d86716ffb0a" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_262bc7a9-cc64-4172-a48c-d512a84e4b53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_df43ea73-5a58-46a4-a565-42e418c1eb1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_65222cf5-a01a-4ef2-8ac0-1d86716ffb0a" xlink:to="loc_us-gaap_DerivativeLiabilities_df43ea73-5a58-46a4-a565-42e418c1eb1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_7dd403f1-fbb3-4488-b759-f9574d973b1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_9c3fadfe-5f1f-4c6c-ba36-e15fbcaca784" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeCollateralObligationToReturnSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_7dd403f1-fbb3-4488-b759-f9574d973b1f" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_9c3fadfe-5f1f-4c6c-ba36-e15fbcaca784" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_c0f7c976-c335-493c-aadd-ab1dcc0e36d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_7dd403f1-fbb3-4488-b759-f9574d973b1f" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_c0f7c976-c335-493c-aadd-ab1dcc0e36d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_62427bde-1ecf-40e4-8e47-ffef0fbfc8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_7dd403f1-fbb3-4488-b759-f9574d973b1f" xlink:to="loc_us-gaap_DerivativeAssets_62427bde-1ecf-40e4-8e47-ffef0fbfc8a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_82e3711a-379b-4fb3-9549-950ee74bf79b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_14d0e002-c706-4bbe-bb14-93e5ffb47005" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossAsset"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_82e3711a-379b-4fb3-9549-950ee74bf79b" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_14d0e002-c706-4bbe-bb14-93e5ffb47005" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_38426bf5-6c02-4175-a3e6-0c60c6a3ee5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_82e3711a-379b-4fb3-9549-950ee74bf79b" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_38426bf5-6c02-4175-a3e6-0c60c6a3ee5d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/FairValueMeasurementsSummaryofFinancialInstrumentsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_bc8a0d95-d1c0-4b1f-a4f7-10b9e9719056" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_6c7d9723-b9d7-462d-bffd-67af5df2fef7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_bc8a0d95-d1c0-4b1f-a4f7-10b9e9719056" xlink:to="loc_us-gaap_DerivativeLiabilities_6c7d9723-b9d7-462d-bffd-67af5df2fef7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_01414106-870d-49d3-a45c-b171cd11e966" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_OtherInvestmentsFairValueDisclosure_f3232e45-ad79-418c-8d30-3494698a9a4e" xlink:href="efsc-20220930.xsd#efsc_OtherInvestmentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_01414106-870d-49d3-a45c-b171cd11e966" xlink:to="loc_efsc_OtherInvestmentsFairValueDisclosure_f3232e45-ad79-418c-8d30-3494698a9a4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4020c278-0eeb-4b25-8468-3be56c8cff84" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_01414106-870d-49d3-a45c-b171cd11e966" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4020c278-0eeb-4b25-8468-3be56c8cff84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_f3cbf529-8ba8-4f3f-a005-626f68004a8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_01414106-870d-49d3-a45c-b171cd11e966" xlink:to="loc_us-gaap_DerivativeAssets_f3cbf529-8ba8-4f3f-a005-626f68004a8b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/FairValueMeasurementsCertainAssetsatFairValueonaNonrecurringBasisDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#FairValueMeasurementsCertainAssetsatFairValueonaNonrecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/FairValueMeasurementsCertainAssetsatFairValueonaNonrecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_ad0160b4-7524-4b6e-b084-dde00cb8b429" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_OtherRealEstateFairValueDisclosure_1426d199-a7af-437e-8446-88da1c85d71d" xlink:href="efsc-20220930.xsd#efsc_OtherRealEstateFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_ad0160b4-7524-4b6e-b084-dde00cb8b429" xlink:to="loc_efsc_OtherRealEstateFairValueDisclosure_1426d199-a7af-437e-8446-88da1c85d71d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_70151874-bcab-4798-a2a1-2035079fdbb8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_ad0160b4-7524-4b6e-b084-dde00cb8b429" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_70151874-bcab-4798-a2a1-2035079fdbb8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.enterprisebank.com/role/SHAREHOLDERSEQUITYPretaxandAftertaxChangesintheComponentsofOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="efsc-20220930.xsd#SHAREHOLDERSEQUITYPretaxandAftertaxChangesintheComponentsofOtherComprehensiveIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.enterprisebank.com/role/SHAREHOLDERSEQUITYPretaxandAftertaxChangesintheComponentsofOtherComprehensiveIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_71dbbace-4c49-4d51-a2f8-6aa4837bf717" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_2fcffab0-39bb-4bbd-ac97-1ab9c88d7a4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_71dbbace-4c49-4d51-a2f8-6aa4837bf717" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_2fcffab0-39bb-4bbd-ac97-1ab9c88d7a4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationTax_7dafd377-5881-4971-a380-6765a7a05f26" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_71dbbace-4c49-4d51-a2f8-6aa4837bf717" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationTax_7dafd377-5881-4971-a380-6765a7a05f26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments_770b1f54-fc1d-48fa-be86-71c3583496b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiBeforeTaxAfterAdjustments_6c7a0145-e4af-4da0-a3a2-98165e96fcc9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiBeforeTaxAfterAdjustments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments_770b1f54-fc1d-48fa-be86-71c3583496b3" xlink:to="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiBeforeTaxAfterAdjustments_6c7a0145-e4af-4da0-a3a2-98165e96fcc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterAdjustmentsTax_5d93718d-46fc-4feb-b6be-25a147f443bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterAdjustmentsTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterTaxAndAdjustments_770b1f54-fc1d-48fa-be86-71c3583496b3" xlink:to="loc_us-gaap_OtherComprehensiveLossHeldToMaturitySecurityOttiAfterAdjustmentsTax_5d93718d-46fc-4feb-b6be-25a147f443bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_d39921ba-7d20-40ae-bec1-12a8ea2c0718" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_3afb15aa-8be5-43c8-8739-4685f3e6ba7d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_d39921ba-7d20-40ae-bec1-12a8ea2c0718" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_3afb15aa-8be5-43c8-8739-4685f3e6ba7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_36af2359-a479-4b5f-b725-b2a4b109740a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_d39921ba-7d20-40ae-bec1-12a8ea2c0718" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_36af2359-a479-4b5f-b725-b2a4b109740a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_af2834ad-6c20-466b-b6c6-05d9589a90f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_4d1c0198-e113-4c62-bf44-22819d4306d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_af2834ad-6c20-466b-b6c6-05d9589a90f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_4d1c0198-e113-4c62-bf44-22819d4306d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_eb1036a1-2dbc-434a-b4b6-bbda7d23a215" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_af2834ad-6c20-466b-b6c6-05d9589a90f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_eb1036a1-2dbc-434a-b4b6-bbda7d23a215" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_e7ecaa05-4717-450d-85ad-14aa62ffb3d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_170cf7d3-7d3f-47a9-8743-04e3cc20d925" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_e7ecaa05-4717-450d-85ad-14aa62ffb3d5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_170cf7d3-7d3f-47a9-8743-04e3cc20d925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_16b56210-750e-482f-8c7a-4b69f6de9a8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_e7ecaa05-4717-450d-85ad-14aa62ffb3d5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_16b56210-750e-482f-8c7a-4b69f6de9a8c" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
