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  <xs:element id="efsc_FinancingReceivableCreditLossExpenseReversalAdditionalProvision" abstract="false" name="FinancingReceivableCreditLossExpenseReversalAdditionalProvision" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_PrimeBasedInterestRateCollarMember" abstract="true" name="PrimeBasedInterestRateCollarMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_DeferredCompensationPlanMember" abstract="true" name="DeferredCompensationPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_FederalHomeLoanBankAdvancesMaturitiesSummaryAverageInterestRateofAmountsDueinOnetoFiveYearsofBalanceSheetDate" abstract="false" name="FederalHomeLoanBankAdvancesMaturitiesSummaryAverageInterestRateofAmountsDueinOnetoFiveYearsofBalanceSheetDate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableUnderEmployeeStockPurchasePlan" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableUnderEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="efsc_CommunityDevelopmentFeesMember" abstract="true" name="CommunityDevelopmentFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_FurnitureFixturesAndEquipmentMember" abstract="true" name="FurnitureFixturesAndEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_LoansByMajorCategoryAxis" abstract="true" name="LoansByMajorCategoryAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="efsc_Convertibleadvancesweightedaverageinterestrate" abstract="false" name="Convertibleadvancesweightedaverageinterestrate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_ConstructionAndLandDevelopmentFinancingReceivableMember" abstract="true" name="ConstructionAndLandDevelopmentFinancingReceivableMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_CashFlowHedge2Member" abstract="true" name="CashFlowHedge2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_OutstandingLongTermIncentiveAwardsTableTextBlock" abstract="false" name="OutstandingLongTermIncentiveAwardsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_OtherRealEstateMember" abstract="true" name="OtherRealEstateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_InterestBearingDomesticDepositBrokeredYearFour" abstract="false" name="InterestBearingDomesticDepositBrokeredYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DebtInstrumentInterestTerm" abstract="false" name="DebtInstrumentInterestTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="efsc_ReclassifiedtoHeldtoMaturityMember" abstract="true" name="ReclassifiedtoHeldtoMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_ProvisionForLoanLossesNotCoveredUnderFdicLossShare" abstract="false" name="ProvisionForLoanLossesNotCoveredUnderFdicLossShare" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_LoanLegalExpensesMember" abstract="true" name="LoanLegalExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_DeferredTaxLiabilitiesOtherInvestments" abstract="false" name="DeferredTaxLiabilitiesOtherInvestments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_TransferFromFixedAssetsToLoans" abstract="false" name="TransferFromFixedAssetsToLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CondensedCashFlowStatmentOfParentCompanyOnlyDisclosureTableTextBlock" abstract="false" name="CondensedCashFlowStatmentOfParentCompanyOnlyDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_OtherComprehensiveIncomeLossReclassificationofgainlossonheldtomaturitysecuritiestax" abstract="false" name="OtherComprehensiveIncomeLossReclassificationofgainlossonheldtomaturitysecuritiestax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DepositarySharesIssuedAndSold" abstract="false" name="DepositarySharesIssuedAndSold" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingWeightedAverageExercisePrice" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="efsc_CollateralPledged" abstract="false" name="CollateralPledged" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_LoansAndLeasesReceivableNetReportedAmountFairValueDisclosure" abstract="false" name="LoansAndLeasesReceivableNetReportedAmountFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_StockOptionsAndStockSettledStockAppreciationRightsMember" abstract="true" name="StockOptionsAndStockSettledStockAppreciationRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisableWeightedAverageExercisePrice" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisableWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="efsc_RepaymentOfPPPLFAdvances" abstract="false" name="RepaymentOfPPPLFAdvances" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_FinancingReceivableCoveredAfterAllowanceForCreditLossAndUnearnedLoanFeesNet" abstract="false" name="FinancingReceivableCoveredAfterAllowanceForCreditLossAndUnearnedLoanFeesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_StateTaxCreditsHeldForSaleMember" abstract="true" name="StateTaxCreditsHeldForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_DebtInstrumentRemainingTerm" abstract="false" name="DebtInstrumentRemainingTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="efsc_GainOnStateTaxCreditsNet" abstract="false" name="GainOnStateTaxCreditsNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_FDICAndOtherInsurnaceMember" abstract="true" name="FDICAndOtherInsurnaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_NoncoveredLoansMember" abstract="true" name="NoncoveredLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_InitialAllowanceOnAcquiredPCDLoans" abstract="false" name="InitialAllowanceOnAcquiredPCDLoans" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_Sharesissuedinconnectionwithacquisition" abstract="false" name="Sharesissuedinconnectionwithacquisition" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_LoansAndLeaseReceivableIncludingUnearnedLoanFees" abstract="false" name="LoansAndLeaseReceivableIncludingUnearnedLoanFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_FinancingRecievablePaycheckProtectionProgramUnearnedFees" abstract="false" name="FinancingRecievablePaycheckProtectionProgramUnearnedFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CoveredLoansTable" abstract="true" name="CoveredLoansTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="efsc_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsDeferredCompensation" abstract="false" name="DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsDeferredCompensation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DeferredTaxAssetsLoansHeldForSale" abstract="false" name="DeferredTaxAssetsLoansHeldForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_LoansClassifiedByRiskCategoryMember" abstract="true" name="LoansClassifiedByRiskCategoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_InterestBearingDomesticDepositBrokeredYearFive" abstract="false" name="InterestBearingDomesticDepositBrokeredYearFive" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_LoanServicingAssetMember" abstract="true" name="LoanServicingAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_StockIssuedDuringPeriodSharesAcquisitionsGross" abstract="false" name="StockIssuedDuringPeriodSharesAcquisitionsGross" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingWeightedAverageRemainingContractualTerm" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingWeightedAverageRemainingContractualTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="efsc_EnterpriseBankAndTrustMember" abstract="true" name="EnterpriseBankAndTrustMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisesInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisesInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="efsc_Investmentstrustpreferredsecurities" abstract="false" name="Investmentstrustpreferredsecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_ScheduleOfCommitmentsLineItems" abstract="true" name="ScheduleOfCommitmentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="efsc_FixedRateLoanCommitmentMember" abstract="true" name="FixedRateLoanCommitmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_OtherComprehensiveIncomeLossReclassificationofgainlossonheldtomaturitysecuritiesnetoftax" abstract="false" name="OtherComprehensiveIncomeLossReclassificationofgainlossonheldtomaturitysecuritiesnetoftax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_ContractualMaturitiesTimeDepositsLessThan100000Abstract" abstract="true" name="ContractualMaturitiesTimeDepositsLessThan100000Abstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantsInPeriodWeightedAverageExercisePrice" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantsInPeriodWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="efsc_Durationofunrecognizedtaxbenefits" abstract="false" name="Durationofunrecognizedtaxbenefits" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="efsc_TrinityCapitalTrustVMember" abstract="true" name="TrinityCapitalTrustVMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_PaymentsToAcquireStateTaxCreditsHeldForSale" abstract="false" name="PaymentsToAcquireStateTaxCreditsHeldForSale" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_UnrecognizedCompensationCostLongTermIncentives" abstract="false" name="UnrecognizedCompensationCostLongTermIncentives" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_TargetSharesIssuableasLongTermIncentiveAwards" abstract="false" name="TargetSharesIssuableasLongTermIncentiveAwards" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_JEFFCOStatTrustIIMember" abstract="true" name="JEFFCOStatTrustIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_EfscCapitalTrustViiMember" abstract="true" name="EfscCapitalTrustViiMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_AmortizationExpenseMember" abstract="true" name="AmortizationExpenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodLineItems" abstract="true" name="SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="efsc_ResidentialRealEstateFinancingReceivableMember" abstract="true" name="ResidentialRealEstateFinancingReceivableMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_CommercialAndIndustrialPortfolioSegmentMember" abstract="true" name="CommercialAndIndustrialPortfolioSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_LoansClassifiedByPerformingStatusMember" abstract="true" name="LoansClassifiedByPerformingStatusMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_FederalHomeLoanBankAdvancesMaturityOneWeek" abstract="false" name="FederalHomeLoanBankAdvancesMaturityOneWeek" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DividendsfromOtherSubsidiaries" abstract="false" name="DividendsfromOtherSubsidiaries" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_AcquiredPCDLoansTableTextBlock" abstract="false" name="AcquiredPCDLoansTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_CoveredLoansLineItems" abstract="true" name="CoveredLoansLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="efsc_NumberOfBranchesClosed" abstract="false" name="NumberOfBranchesClosed" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="efsc_UnadvancedCommitmentOnImpairedLoanMember" abstract="true" name="UnadvancedCommitmentOnImpairedLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_Reclassificationfortheadoptionofnewaccountingstandards" abstract="false" name="Reclassificationfortheadoptionofnewaccountingstandards" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CondensedIncomeStatementOfParentCompanyOnlyDisclosureTableTextBlock" abstract="false" name="CondensedIncomeStatementOfParentCompanyOnlyDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_EnterpriseFinancialCdeLlcMember" abstract="true" name="EnterpriseFinancialCdeLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_FixedInterestRateAxis" abstract="true" name="FixedInterestRateAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="efsc_SecuredOvernightFinancingRateSOFRMember" abstract="true" name="SecuredOvernightFinancingRateSOFRMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_TierOneCommonEquityCapitalRequiredtobeWellCapitalizedtoRiskWeightedAssets" abstract="false" name="TierOneCommonEquityCapitalRequiredtobeWellCapitalizedtoRiskWeightedAssets" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_DesMoinesMember" abstract="true" name="DesMoinesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_EfscCapitalTrustViMember" abstract="true" name="EfscCapitalTrustViMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_NetPremiumAcquiredLoans" abstract="false" name="NetPremiumAcquiredLoans" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_BranchClosureExpenses" abstract="false" name="BranchClosureExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_ContractualAmountsOfOffBalanceSheetFinancialInstruments" abstract="false" name="ContractualAmountsOfOffBalanceSheetFinancialInstruments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_InterestBearingDomesticDepositOtherTimeDepositNextTwelveMonths" abstract="false" name="InterestBearingDomesticDepositOtherTimeDepositNextTwelveMonths" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_ConsumerAndOtherPortfolioSegmentMember" abstract="true" name="ConsumerAndOtherPortfolioSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_ConstructionRealEstatePortfolioSegmentMember" abstract="true" name="ConstructionRealEstatePortfolioSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_GoodwillAcquiredThroughAcquisition" abstract="false" name="GoodwillAcquiredThroughAcquisition" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_NumberOfStatesCompanyFilesIncomeTaxReturnsWith" abstract="false" name="NumberOfStatesCompanyFilesIncomeTaxReturnsWith" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantsInPeriodGross" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardGrantsInPeriodGross" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="efsc_CapitaltoRiskWeightedAssetsCCBMinimum" abstract="false" name="CapitaltoRiskWeightedAssetsCCBMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_ScheduleOfAccountsNotesLoansAndFinancingReceivableExcludingAllowanceForCreditLossesTableTextBlock" abstract="false" name="ScheduleOfAccountsNotesLoansAndFinancingReceivableExcludingAllowanceForCreditLossesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_TierOneCommonEquityCapitalCCBMinimum" abstract="false" name="TierOneCommonEquityCapitalCCBMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_FinancingReceivableUnearnedLoanFeesNet" abstract="false" name="FinancingReceivableUnearnedLoanFeesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CDARSDeposits" abstract="false" name="CDARSDeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CardServicesRevenueMember" abstract="true" name="CardServicesRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_FederalHomeLoanBankStockPolicyPolicyTextBlock" abstract="false" name="FederalHomeLoanBankStockPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
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  <xs:element id="efsc_OtherComprehensiveIncomeLossReclassificationOfGainLossOnHeldToMaturitySecuritiesBeforeOfTax" abstract="false" name="OtherComprehensiveIncomeLossReclassificationOfGainLossOnHeldToMaturitySecuritiesBeforeOfTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CommercialRealEstateOwnerOccupiedFinancingReceivableMember" abstract="true" name="CommercialRealEstateOwnerOccupiedFinancingReceivableMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="efsc_StLouisMember" abstract="true" name="StLouisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="efsc_SharebasedCompensationArrangementbySharebasedPaymentAwardMaximumEmployeeSubscriptionRateBonus" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardMaximumEmployeeSubscriptionRateBonus" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" abstract="true" name="SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
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  <xs:element id="efsc_LifeInsuranceCashSurrenderValuePolicyPolicyTextBlock" abstract="false" name="LifeInsuranceCashSurrenderValuePolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
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  <xs:element id="efsc_BankOwnedLifeInsuranceMember" abstract="true" name="BankOwnedLifeInsuranceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_Incometaxbenefitlowincomehousingtaxcredits" abstract="false" name="Incometaxbenefitlowincomehousingtaxcredits" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_LoansByMajorCategoryDomain" abstract="true" name="LoansByMajorCategoryDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer" abstract="false" name="MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_FinancialAsset3089DaysPastDueMember" abstract="true" name="FinancialAsset3089DaysPastDueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="efsc_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnCashFlowHedgesBeforeTax" abstract="false" name="OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnCashFlowHedgesBeforeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_FinancingReceivableCreditLossExpenseReversalAcquisitionRelatedExpense" abstract="false" name="FinancingReceivableCreditLossExpenseReversalAcquisitionRelatedExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_InterestRateCollarMember" abstract="true" name="InterestRateCollarMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_CashFlowHedge4Member" abstract="true" name="CashFlowHedge4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="efsc_MergerRelatedExpenses" abstract="false" name="MergerRelatedExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_StockPlanForNonManagementDirectorsMember" abstract="true" name="StockPlanForNonManagementDirectorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="efsc_BankingExpensesMember" abstract="true" name="BankingExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="efsc_CommercialRealEstateInvestorOwnedFinancingReceivableMember" abstract="true" name="CommercialRealEstateInvestorOwnedFinancingReceivableMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementBySharBasedPaymentAwardNumberOfSharesAvailableForGrantDeferredShares" abstract="false" name="ShareBasedCompensationArrangementBySharBasedPaymentAwardNumberOfSharesAvailableForGrantDeferredShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" abstract="false" name="ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_TaxCreditsHeldForSalePolicyPolicyTextBlock" abstract="false" name="TaxCreditsHeldForSalePolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_FinancingReceivablePaycheckProtectionProgram" abstract="false" name="FinancingReceivablePaycheckProtectionProgram" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_ICSDeposits" abstract="false" name="ICSDeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_TierOneLeverageCapitaltoAverageAssetsCCBMinimum" abstract="false" name="TierOneLeverageCapitaltoAverageAssetsCCBMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="efsc_AccruedInterestReceivableHeldToMaturitySecurities" abstract="false" name="AccruedInterestReceivableHeldToMaturitySecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember" abstract="true" name="CommercialRealEstateInvestorOwnedPortfolioSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_CashFlowHedge1Member" abstract="true" name="CashFlowHedge1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_DeferedTaxAssetsLeaseLiabilityAccrual" abstract="false" name="DeferedTaxAssetsLeaseLiabilityAccrual" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_TimeDeposits250000orMore" abstract="false" name="TimeDeposits250000orMore" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DeferredTaxAssetsOtherInvestments" abstract="false" name="DeferredTaxAssetsOtherInvestments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_CommercialRealEstateOwnerOccupiedPortfolioSegmentMember" abstract="true" name="CommercialRealEstateOwnerOccupiedPortfolioSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_RealEstateLoansPortfolioSegmentMember" abstract="true" name="RealEstateLoansPortfolioSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_BlanketLienMember" abstract="true" name="BlanketLienMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_CondensedBalanceSheetOfParentCompanyOnlyDisclosureTableTextBlock" abstract="false" name="CondensedBalanceSheetOfParentCompanyOnlyDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_EfscCapitalTrustIiMember" abstract="true" name="EfscCapitalTrustIiMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_BasisOfAccountingAndConsolidationPolicyPolicyTextBlock" abstract="false" name="BasisOfAccountingAndConsolidationPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_EnterpriseValueLendingPortfolioNicheSegmentMember" abstract="true" name="EnterpriseValueLendingPortfolioNicheSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_EfscStatutoryTrustVMember" abstract="true" name="EfscStatutoryTrustVMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_NumberofUnconsolidatedStatutoryBusinessTrusts" abstract="false" name="NumberofUnconsolidatedStatutoryBusinessTrusts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="efsc_RepaymentsOfLongTermFederalHomeLoanBankAdvances" abstract="false" name="RepaymentsOfLongTermFederalHomeLoanBankAdvances" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_LoansAndLeasesReceivableImpairedLoansCommitmentToLendReserve" abstract="false" name="LoansAndLeasesReceivableImpairedLoansCommitmentToLendReserve" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses" abstract="false" name="DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife" abstract="false" name="DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="efsc_OutsideServicesMember" abstract="true" name="OutsideServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_ProceedsFromSaleOfStateTaxCreditsHeldForSale" abstract="false" name="ProceedsFromSaleOfStateTaxCreditsHeldForSale" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_FederalHomeLoanBankAdvancesOvernightFunds" abstract="false" name="FederalHomeLoanBankAdvancesOvernightFunds" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_UnsecuredTermLoanAgreementTermLoanMember" abstract="true" name="UnsecuredTermLoanAgreementTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="efsc_InterestBearingDomesticDepositBrokeredYearTwo" abstract="false" name="InterestBearingDomesticDepositBrokeredYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="efsc_OtherRealEstatePolicyPolicyTextBlock" abstract="false" name="OtherRealEstatePolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="efsc_NetAccretionOfLoanDiscountAndIndemnificationAsset" abstract="false" name="NetAccretionOfLoanDiscountAndIndemnificationAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
