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    <link:label id="lab_us-gaap_Deposits_ba8bf6da-3619-48bb-8b31-c5b31b463264_totalLabel_en-US" xlink:label="lab_us-gaap_Deposits" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total deposits</link:label>
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    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_dc97af32-c2d1-4462-a7ee-ce33f0265a4c_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesLeasingArrangements" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Right of use asset</link:label>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesLeasingArrangements" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Leasing Arrangements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
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    <link:label id="lab_us-gaap_OtherLiabilitiesDisclosureAbstract_e6917f7d-b451-4a80-a520-cc71a878be29_terseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Liabilities Disclosure [Abstract]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesDisclosureAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesDisclosureAbstract"/>
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    <link:label id="lab_us-gaap_DepositLiabilitiesDisclosuresTextBlock_b1a9bbe7-aa9a-4288-8790-cd34f4a2ec47_terseLabel_en-US" xlink:label="lab_us-gaap_DepositLiabilitiesDisclosuresTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deposits</link:label>
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    <link:label id="lab_us-gaap_OtherNoninterestExpense_27926762-b219-447a-b44a-0ea5d8038866_terseLabel_en-US" xlink:label="lab_us-gaap_OtherNoninterestExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other expenses</link:label>
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    <link:label id="lab_us-gaap_FairValueDisclosureItemAmountsDomain_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosureItemAmountsDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurement [Domain]</link:label>
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    <link:label id="lab_us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_cab8f696-4bc3-4407-86cc-0d421b3d6930_terseLabel_en-US" xlink:label="lab_us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">To Be Well Capitalized Under Applicable Action Provisions, Ratio</link:label>
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    <link:label id="lab_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_7f2eb55a-5fd6-49fd-ade1-de09137ba4ce_terseLabel_en-US" xlink:label="lab_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cumulative Effect, Period of Adoption, Adjustment</link:label>
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    <link:label id="lab_us-gaap_TroubledDebtRestructuringsOnFinancingReceivablesTableTextBlock_c0495df9-8b85-477a-ab83-51b50252ca1b_terseLabel_en-US" xlink:label="lab_us-gaap_TroubledDebtRestructuringsOnFinancingReceivablesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Summary of Recorded Investment by for Portfolio Loans Restructured</link:label>
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    <link:label id="lab_us-gaap_PassMember_95ca7faf-f4de-43bc-834e-6894261a282c_terseLabel_en-US" xlink:label="lab_us-gaap_PassMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pass (1-6)</link:label>
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    <link:label id="lab_efsc_TransferFromFixedAssetsToLoans_c742ef58-3d22-484f-8fe4-45f90ce42392_terseLabel_en-US" xlink:label="lab_efsc_TransferFromFixedAssetsToLoans" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Transfer from fixed assets to loans</link:label>
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    <link:label id="lab_us-gaap_OtherNoncashIncomeExpense_630a2d38-a916-4a88-a25b-0a3c87c18411_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherNoncashIncomeExpense" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other, net</link:label>
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    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_e61a0922-4177-4bc3-96f3-e644a3516329_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Fair Value, Gross Asset</link:label>
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    <link:label id="lab_efsc_InterestRateCollarMember_7d227d8f-8de9-4432-a1f3-e88a0ebf5103_terseLabel_en-US" xlink:label="lab_efsc_InterestRateCollarMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest rate collar</link:label>
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    <link:label id="lab_efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisableNumber_cdb229cc-4b96-415a-83c9-c13a39a67c75_terseLabel_en-US" xlink:label="lab_efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardExercisableNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercisable (in shares)</link:label>
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    <link:label id="lab_us-gaap_TimeDepositMaturitiesYearThree_dae881ad-963b-4146-b3a5-69074eb49c14_totalLabel_en-US" xlink:label="lab_us-gaap_TimeDepositMaturitiesYearThree" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 2 years and less than 3 years</link:label>
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    <link:label id="lab_efsc_AcquiredPCDLoansTableTextBlock_2e52d437-32dd-4e24-9c6b-b1c64a346f41_terseLabel_en-US" xlink:label="lab_efsc_AcquiredPCDLoansTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Acquired PCD Loans</link:label>
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    <link:label id="lab_dei_EntitySmallBusiness_d931240e-3b9c-4276-84a7-00ad8e02e771_terseLabel_en-US" xlink:label="lab_dei_EntitySmallBusiness" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Small Business</link:label>
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    <link:label id="lab_us-gaap_LongtermDebtTypeDomain_82449076-9b52-4328-b0f0-3a9515838921_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Debt, Type [Domain]</link:label>
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    <link:label id="lab_efsc_EfscCapitalTrustIiMember_008bfbb1-a818-4581-80d9-4bdff5dacad8_terseLabel_en-US" xlink:label="lab_efsc_EfscCapitalTrustIiMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">EFSC Capital Trust II</link:label>
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    <link:label id="lab_us-gaap_CollateralDomain_95b89434-d6d4-4075-b5bd-d70539f7f831_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Collateral [Domain]</link:label>
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    <link:label id="lab_us-gaap_OtherAssetsMember_5300760b-869a-497d-a019-2a90172b161e_terseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets</link:label>
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    <link:label id="lab_us-gaap_NotesReceivableNet_fc3e4950-71e0-42f4-a863-94b13c1118ce_terseLabel_en-US" xlink:label="lab_us-gaap_NotesReceivableNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable, after Allowance for Credit Loss</link:label>
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    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_0e967bd9-8a07-422b-ae60-59a2357b420e_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property plant and equipment useful life</link:label>
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    <link:label id="lab_us-gaap_StockholdersEquityAbstract_949cb160-840d-4132-b419-c2e8b2cdd307_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shareholders' equity:</link:label>
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    <link:label id="lab_efsc_CommunityDevelopmentFeesMember_966ba87a-874d-41ee-b914-f250931217d3_terseLabel_en-US" xlink:label="lab_efsc_CommunityDevelopmentFeesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Community Development Fees</link:label>
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    <link:label id="lab_us-gaap_Land_01738223-18f2-4018-bd09-d633645a2664_terseLabel_en-US" xlink:label="lab_us-gaap_Land" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Land</link:label>
    <link:label id="lab_us-gaap_Land_label_en-US" xlink:label="lab_us-gaap_Land" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Land</link:label>
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    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_367078ce-b87c-49f6-85ba-6272e70a367b_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unsecured term loan, face amount</link:label>
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    <link:label id="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetResidualValue_b5b2a5ad-b642-4cbe-adce-18bc3af58060_terseLabel_en-US" xlink:label="lab_us-gaap_AcquiredFiniteLivedIntangibleAssetResidualValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Acquired Finite-lived Intangible Asset, Residual Value</link:label>
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    <link:label id="lab_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses_1826b051-14bb-4599-a6e6-0dd05500b0b8_terseLabel_en-US" xlink:label="lab_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">debt securities, held to maturity, net of alloawance for credit losses</link:label>
    <link:label id="lab_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses_label_en-US" xlink:label="lab_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">debt securities, held to maturity, net of allowance for credit losses</link:label>
    <link:label id="lab_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses_documentation_en-US" xlink:label="lab_efsc_DebtSecuritiesHeldToMaturityNetOfAllowanceForCreditLosses" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">debt securities, held to maturity, net of allowance for credit losses</link:label>
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    <link:label id="lab_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration_d29e7240-e6af-4558-9cf2-9d6d57f335d7_terseLabel_en-US" xlink:label="lab_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Right to receive state tax credit at agreed upon rates</link:label>
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    <link:label id="lab_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration_documentation_en-US" xlink:label="lab_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Credits, Right to Receive at Agreed Upon Rates, Duration</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration" xlink:href="efsc-20221231.xsd#efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration" xlink:to="lab_efsc_TaxCreditsRightToReceiveAtAgreedUponRatesDuration" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_InterestBearingDomesticDepositBrokeredYearTwo_01669649-0e6f-4208-8739-69426c4d65fa_terseLabel_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositBrokeredYearTwo" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 1 year and less than 2 years</link:label>
    <link:label id="lab_efsc_InterestBearingDomesticDepositBrokeredYearTwo_label_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositBrokeredYearTwo" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Bearing Domestic Deposit, Brokered, Year Two</link:label>
    <link:label id="lab_efsc_InterestBearingDomesticDepositBrokeredYearTwo_documentation_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositBrokeredYearTwo" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Bearing Domestic Deposit, Brokered, Year Two</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_InterestBearingDomesticDepositBrokeredYearTwo" xlink:href="efsc-20221231.xsd#efsc_InterestBearingDomesticDepositBrokeredYearTwo"/>
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    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_f07da0c2-1abb-4dab-9413-d38cf373bef2_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax benefit from compensation expense</link:label>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_label_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Payment Arrangement, Expense, Tax Benefit</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherThanTemporaryImpairmentCreditLossesRecognizedInEarningsCategoriesOfInvestmentsDomain"/>
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    <link:label id="lab_efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife_0c5f297c-5bb9-46aa-bc58-e77e6cc69bb8_terseLabel_en-US" xlink:label="lab_efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average life (in years)</link:label>
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    <link:label id="lab_efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife_documentation_en-US" xlink:label="lab_efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Mortgage Backed Securities, Weighted Average Life</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife" xlink:href="efsc-20221231.xsd#efsc_DebtSecuritiesMortgageBackedSecuritiesWeightedAverageLife"/>
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    <link:label id="lab_us-gaap_USTreasuryBillSecuritiesMember_3fcba347-b306-4253-b73c-2aeab3ed4cb3_terseLabel_en-US" xlink:label="lab_us-gaap_USTreasuryBillSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Treasury Bill Securities [Member]</link:label>
    <link:label id="lab_us-gaap_USTreasuryBillSecuritiesMember_label_en-US" xlink:label="lab_us-gaap_USTreasuryBillSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Treasury Bill Securities [Member]</link:label>
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    <link:label id="lab_us-gaap_RestrictedStockUnitsRSUMember_ec5a2744-c610-4032-921a-17106f5f15b4_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedStockUnitsRSUMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Stock Units (RSUs) [Member]</link:label>
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    <link:label id="lab_efsc_DeferredTaxAssetsLoansHeldForSale_93c50922-1363-4490-a9ac-d8d1e4fe7514_terseLabel_en-US" xlink:label="lab_efsc_DeferredTaxAssetsLoansHeldForSale" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans held-for-sale</link:label>
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    <link:label id="lab_us-gaap_DeferredIncomeTaxLiabilities_ff25ad48-9f24-4eb4-89c3-3632e5bbf5c8_totalLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total deferred tax liabilities</link:label>
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    <link:label id="lab_us-gaap_PrepaidExpenseAndOtherAssets_2b825bbd-8dac-4b34-80a6-2912f6cc7a7c_terseLabel_en-US" xlink:label="lab_us-gaap_PrepaidExpenseAndOtherAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other assets</link:label>
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    <link:label id="lab_us-gaap_ProceedsFromDividendsReceived_d83119c7-7669-430a-8d6a-785556e557ed_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromDividendsReceived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends from subsidiaries</link:label>
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_d5067107-2da4-4368-a8db-11432902b16c_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Available for sale, Estimated Fair Value</link:label>
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    <link:label id="lab_efsc_CashFlowHedge4Member_d9ee8b33-5e1d-4c85-adc2-2eaa5e49180b_terseLabel_en-US" xlink:label="lab_efsc_CashFlowHedge4Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Flow Hedge Due March 17, 2026</link:label>
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    <link:label id="lab_efsc_LoanServicingAssetMember_2cf8f8da-d828-4902-a752-581c6dfadbb8_terseLabel_en-US" xlink:label="lab_efsc_LoanServicingAssetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loan servicing asset</link:label>
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    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_dd53c198-9bce-4bb0-a172-54ddc2a9dadb_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Type [Domain]</link:label>
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    <link:label id="lab_us-gaap_FairValueByBalanceSheetGroupingTable_4c79bb36-c7ad-4050-84dd-954f90ee5207_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByBalanceSheetGroupingTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, by Balance Sheet Grouping [Table]</link:label>
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    <link:label id="lab_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9c31d94f-14be-4aca-bbd8-ea76324245ae_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year</link:label>
    <link:label id="lab_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_label_en-US" xlink:label="lab_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lessee, Operating Lease, Liability, to be Paid, Year One</link:label>
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    <link:label id="lab_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_dee0a1ee-656c-4a8a-b843-957518d2fec3_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Accounts, Notes, Loans and Financing Receivable [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Accounts, Notes, Loans and Financing Receivable [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
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    <link:label id="lab_efsc_FixedRateLoanCommitmentMember_83a97ccf-ac7d-4705-8ae8-0049a1f4da3f_terseLabel_en-US" xlink:label="lab_efsc_FixedRateLoanCommitmentMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed Rate Loan Commitment</link:label>
    <link:label id="lab_efsc_FixedRateLoanCommitmentMember_label_en-US" xlink:label="lab_efsc_FixedRateLoanCommitmentMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed Rate Loan Commitment [Member]</link:label>
    <link:label id="lab_efsc_FixedRateLoanCommitmentMember_documentation_en-US" xlink:label="lab_efsc_FixedRateLoanCommitmentMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed Rate Loan Commitment [Member]</link:label>
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    <link:label id="lab_dei_EntityByLocationAxis_a1bb6107-16da-4b77-94b6-509a160b3260_terseLabel_en-US" xlink:label="lab_dei_EntityByLocationAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity by Location [Axis]</link:label>
    <link:label id="lab_dei_EntityByLocationAxis_label_en-US" xlink:label="lab_dei_EntityByLocationAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity by Location [Axis]</link:label>
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    <link:label id="lab_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_18beaa48-6a90-4e7e-8d82-f5ba88ac47c0_terseLabel_en-US" xlink:label="lab_us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred tax assets:</link:label>
    <link:label id="lab_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_label_en-US" xlink:label="lab_us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Components of Deferred Tax Assets [Abstract]</link:label>
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    <link:label id="lab_efsc_TierOneCommonEquityCapitaltoRiskWeightedAssets_f57a57f8-aabc-4532-ad83-71047fb77cfd_terseLabel_en-US" xlink:label="lab_efsc_TierOneCommonEquityCapitaltoRiskWeightedAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tier One Common Equity Capital to Risk Weighted Assets</link:label>
    <link:label id="lab_efsc_TierOneCommonEquityCapitaltoRiskWeightedAssets_label_en-US" xlink:label="lab_efsc_TierOneCommonEquityCapitaltoRiskWeightedAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tier One Common Equity Capital to Risk Weighted Assets</link:label>
    <link:label id="lab_efsc_TierOneCommonEquityCapitaltoRiskWeightedAssets_documentation_en-US" xlink:label="lab_efsc_TierOneCommonEquityCapitaltoRiskWeightedAssets" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tier One Common Equity Capital to Risk Weighted Assets</link:label>
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    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_815f97c2-cb70-4488-9cc4-70544164e23f_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, after Tax</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, after Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
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    <link:label id="lab_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt_37b4d1ee-b287-4983-be1f-282e8441ae10_terseLabel_en-US" xlink:label="lab_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate of pledge secured by certain eligible loans</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt"/>
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    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_c9e468c0-f859-4fa2-84d6-e29b638baa13_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares issued in connection with acquisition (in shares)</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Shares, Acquisitions</link:label>
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    <link:label id="lab_us-gaap_OtherIncome_c962629e-968e-4981-b886-fdee7e724170_terseLabel_en-US" xlink:label="lab_us-gaap_OtherIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_us-gaap_OtherIncome_label_en-US" xlink:label="lab_us-gaap_OtherIncome" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Income</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncome" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherIncome"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherIncome" xlink:to="lab_us-gaap_OtherIncome" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubordinatedBorrowingAxis_f305ba6d-1989-43eb-9c13-59ebb5c0ce2e_terseLabel_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Borrowing [Axis]</link:label>
    <link:label id="lab_us-gaap_SubordinatedBorrowingAxis_label_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Borrowing [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubordinatedBorrowingAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubordinatedBorrowingAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubordinatedBorrowingAxis" xlink:to="lab_us-gaap_SubordinatedBorrowingAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour_916bcd76-97e7-4815-893e-c4458307d74a_terseLabel_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 3 years and less than 4 years</link:label>
    <link:label id="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour_label_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Bearing Domestic Deposit, Other Time Deposit, Year Four</link:label>
    <link:label id="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour_documentation_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Bearing Domestic Deposit, Other Time Deposit, Year Four</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour" xlink:href="efsc-20221231.xsd#efsc_InterestBearingDomesticDepositOtherTimeDepositYearFour"/>
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    <link:label id="lab_efsc_TaxcreditactivitynetMember_1b47f6d0-42fc-45e5-8f7f-02f4ca650f13_terseLabel_en-US" xlink:label="lab_efsc_TaxcreditactivitynetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax credit activity, net [Member]</link:label>
    <link:label id="lab_efsc_TaxcreditactivitynetMember_label_en-US" xlink:label="lab_efsc_TaxcreditactivitynetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax credit activity, net [Member]</link:label>
    <link:label id="lab_efsc_TaxcreditactivitynetMember_documentation_en-US" xlink:label="lab_efsc_TaxcreditactivitynetMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax credit activity, net [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_TaxcreditactivitynetMember" xlink:href="efsc-20221231.xsd#efsc_TaxcreditactivitynetMember"/>
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    <link:label id="lab_us-gaap_PaymentsToAcquireInvestments_b8e5cc2d-5f7f-4c31-95f7-445b6b30fc37_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases of other investments</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireInvestments_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireInvestments"/>
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    <link:label id="lab_us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock_022637a7-95a6-4f54-a17c-a8858eb85aa1_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Payment Arrangement, Cost by Plan [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_SubordinatedBorrowingInterestRate_94f82f24-5e5d-42e8-aa34-bebba7cfa453_terseLabel_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed interest rate</link:label>
    <link:label id="lab_us-gaap_SubordinatedBorrowingInterestRate_label_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingInterestRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Borrowing, Interest Rate</link:label>
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    <link:label id="lab_efsc_JEFFCOStatTrustIIMember_71e64e8b-3f67-48f7-813c-ee3a3e2f768d_terseLabel_en-US" xlink:label="lab_efsc_JEFFCOStatTrustIIMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">JEFFCO Stat Trust II [Member]</link:label>
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    <link:label id="lab_us-gaap_TimeDepositMaturitiesYearFour_c308f920-5b7d-4174-b426-8c999d49d582_totalLabel_en-US" xlink:label="lab_us-gaap_TimeDepositMaturitiesYearFour" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 3 years and less than 4 years</link:label>
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    <link:label id="lab_us-gaap_InvestmentsFairValueDisclosure_fe384c1c-8c15-481a-bcc7-6248e0d20446_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other investments</link:label>
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    <link:label id="lab_efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer_a9c20679-a843-4a25-93cf-51becbd7afcc_terseLabel_en-US" xlink:label="lab_efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum percentage of shareholders' equity security holdings held of one issuer</link:label>
    <link:label id="lab_efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer_label_en-US" xlink:label="lab_efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum percentage of shareholders' equity security holdings held of one issuer</link:label>
    <link:label id="lab_efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer_documentation_en-US" xlink:label="lab_efsc_MaximumPercentageOfShareholdersEquitySecurityHoldingsHeldOfOneIssuer" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum percentage of shareholders' equity security holdings held of one issuer.</link:label>
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    <link:label id="lab_us-gaap_InterestReceivable_6d871d37-7aba-4234-bbd5-db99568ced26_terseLabel_en-US" xlink:label="lab_us-gaap_InterestReceivable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued interest receivable</link:label>
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    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_a2fe5b70-f02b-4dee-b006-34dcce82596c_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed assets, net</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_9d174adb-77bc-4466-a25b-b173f8b091f8_totalLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed assets, net</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Net</link:label>
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    <link:label id="lab_us-gaap_OperatingExpenses_5e0701a5-fe49-4de7-ab04-9d6b9c56c76b_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingExpenses" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total expenses</link:label>
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    <link:label id="lab_us-gaap_FinancingReceivableOriginatedInCurrentFiscalYear_8939017a-31d7-4b1d-bbd6-9581469650c0_terseLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivableOriginatedInCurrentFiscalYear" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Year 1</link:label>
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    <link:label id="lab_efsc_Investmentstrustpreferredsecurities_c8965b2e-1361-45b5-820a-5745970d9346_terseLabel_en-US" xlink:label="lab_efsc_Investmentstrustpreferredsecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments trust preferred securities</link:label>
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    <link:label id="lab_us-gaap_DividendsPreferredStockCash_d5229d31-4ade-4db8-a3ea-487a053f6366_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DividendsPreferredStockCash" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred stock dividends ($53.889 per share)</link:label>
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    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_cfbae4fb-8e11-4a46-9c30-9bd64ad549cf_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss) [Line Items]</link:label>
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    <link:label id="lab_efsc_Convertibleadvancesweightedaverageinterestrate_17083860-59fd-41bb-9230-558ac27c49b1_terseLabel_en-US" xlink:label="lab_efsc_Convertibleadvancesweightedaverageinterestrate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible advances weighted average interest rate</link:label>
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    <link:label id="lab_us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities_f723dcdd-07ec-4faa-b11d-d3319690d3e6_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleAndMaturityOfHeldToMaturitySecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Paydown or maturity of debt securities, held-to-maturity</link:label>
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    <link:label id="lab_us-gaap_NoninterestExpense_2993f132-9d3c-4bd6-9de7-4f484ec252d7_totalLabel_en-US" xlink:label="lab_us-gaap_NoninterestExpense" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Noninterest expense</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NoninterestExpense" xlink:to="lab_us-gaap_NoninterestExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressPostalZipCode_b0eaae9d-6ad3-48cb-b12e-8aabc77da539_terseLabel_en-US" xlink:label="lab_dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Postal Zip Code</link:label>
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    <link:label id="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFive_d45b3666-8dc1-4cb7-ad29-3567b8d60422_terseLabel_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFive" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 4 years and less than 5 years</link:label>
    <link:label id="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFive_label_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearFive" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Bearing Domestic Deposit, Other Time Deposit, Year Five</link:label>
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    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ebb99bbc-72d2-4f40-b7df-399f73772fe8_totalLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average diluted common shares outstanding (in shares)</link:label>
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    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_4f6da5d2-0215-462a-bf80-1acc712cc9e4_terseLabel_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities sold under agreement to repurchase</link:label>
    <link:label id="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_label_en-US" xlink:label="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Securities Sold under Agreements to Repurchase</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:to="lab_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubordinatedBorrowingsDisclosureTextBlock_91b7c36a-cd52-4be6-8cdf-dcd20fa4bf10_terseLabel_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingsDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Debentures</link:label>
    <link:label id="lab_us-gaap_SubordinatedBorrowingsDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingsDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Borrowings Disclosure [Text Block]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubordinatedBorrowingsDisclosureTextBlock" xlink:to="lab_us-gaap_SubordinatedBorrowingsDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_a23715d7-51cf-44c1-b4a3-ad0675434e82_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Taxes</link:label>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Disclosure [Text Block]</link:label>
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    <link:label id="lab_efsc_CollateralPledged_63b411b0-7641-438e-8ea9-a48a48ad8c99_terseLabel_en-US" xlink:label="lab_efsc_CollateralPledged" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Collateral pledged</link:label>
    <link:label id="lab_efsc_CollateralPledged_label_en-US" xlink:label="lab_efsc_CollateralPledged" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Collateral pledged</link:label>
    <link:label id="lab_efsc_CollateralPledged_documentation_en-US" xlink:label="lab_efsc_CollateralPledged" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Collateral pledged</link:label>
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    <link:label id="lab_us-gaap_LongtermDebtTypeAxis_2b6e528b-f9a2-4743-b2f9-3675a43fc6b7_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Debt, Type [Axis]</link:label>
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    <link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_624696d1-3278-4552-a25d-017c8576c02b_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis spread</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Basis Spread on Variable Rate</link:label>
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    <link:label id="lab_efsc_NetPremiumAcquiredLoans_5d72868a-0d4c-4085-b9c2-1bde75125c83_terseLabel_en-US" xlink:label="lab_efsc_NetPremiumAcquiredLoans" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">net premium, acquired loans</link:label>
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    <link:label id="lab_efsc_NetPremiumAcquiredLoans_documentation_en-US" xlink:label="lab_efsc_NetPremiumAcquiredLoans" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">net premium, acquired loans</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_NetPremiumAcquiredLoans" xlink:href="efsc-20221231.xsd#efsc_NetPremiumAcquiredLoans"/>
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    <link:label id="lab_us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock_60b52848-221e-4ddf-bf6c-28d9488d21f1_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Recorded Investment in Impaired Portfolio Loans by Category</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfFinancingReceivablesNonAccrualStatusTableTextBlock" xlink:type="arc" order="1"/>
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    <link:label id="lab_us-gaap_DeferredTaxAssetsInvestments_7ab674a7-2642-4105-a18f-d882e0d4accb_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized losses on securities, net</link:label>
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    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_306d280c-9573-44c7-9876-a3ed519cdcfb_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
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    <link:label id="lab_efsc_CommercialRealEstateInvestorOwnedFinancingReceivableMember_6ef630a7-2066-4981-a287-08db9ceced82_terseLabel_en-US" xlink:label="lab_efsc_CommercialRealEstateInvestorOwnedFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial - investor owned</link:label>
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    <link:label id="lab_us-gaap_LoansReceivableFairValueDisclosure_d037c109-bf24-43a4-bc42-3865ec8f565d_verboseLabel_en-US" xlink:label="lab_us-gaap_LoansReceivableFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Impaired loans</link:label>
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    <link:label id="lab_us-gaap_OccupancyNet_016ff54e-4139-4a4e-b422-130636dbefeb_terseLabel_en-US" xlink:label="lab_us-gaap_OccupancyNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Occupancy</link:label>
    <link:label id="lab_us-gaap_OccupancyNet_label_en-US" xlink:label="lab_us-gaap_OccupancyNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Occupancy, Net</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OccupancyNet" xlink:to="lab_us-gaap_OccupancyNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CreditFacilityAxis_c5bcc4e8-f10e-4803-989c-87c64daaa7bf_terseLabel_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Facility [Axis]</link:label>
    <link:label id="lab_us-gaap_CreditFacilityAxis_label_en-US" xlink:label="lab_us-gaap_CreditFacilityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Facility [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CreditFacilityAxis" xlink:to="lab_us-gaap_CreditFacilityAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NondesignatedMember_8988e55d-166d-4d10-b0f5-d81460840893_terseLabel_en-US" xlink:label="lab_us-gaap_NondesignatedMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-designated hedging instruments</link:label>
    <link:label id="lab_us-gaap_NondesignatedMember_label_en-US" xlink:label="lab_us-gaap_NondesignatedMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Not Designated as Hedging Instrument [Member]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NondesignatedMember" xlink:to="lab_us-gaap_NondesignatedMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ebc3a6ec-ceb5-4dcc-a31f-b6ae54de3510_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
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    <link:label id="lab_dei_EntityAddressAddressLine1_9715e384-1e72-44eb-851b-75dcec31a19b_terseLabel_en-US" xlink:label="lab_dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line One</link:label>
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    <link:label id="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_a784387d-9746-40cd-96dd-6b79f1be01b1_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less accumulated depreciation and amortization</link:label>
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    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_7aef584d-b239-4555-bcea-89845dbf0b31_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash flows from operating activities:</link:label>
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    <link:label id="lab_dei_EntityShellCompany_c99d8c4e-9dfb-4d4d-9811-244e866d711a_terseLabel_en-US" xlink:label="lab_dei_EntityShellCompany" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Shell Company</link:label>
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    <link:label id="lab_efsc_TierOneLeverageCapitaltoAverageAssetsCCBMinimum_6426f918-dd4a-4543-a793-9992a6c44969_terseLabel_en-US" xlink:label="lab_efsc_TierOneLeverageCapitaltoAverageAssetsCCBMinimum" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tier One Leverage Capital to Average Assets CCB Minimum</link:label>
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    <link:label id="lab_efsc_ResidentialRealEstateFinancingReceivableMember_44b13f96-8f87-431d-be46-5d5bb12e7e3e_verboseLabel_en-US" xlink:label="lab_efsc_ResidentialRealEstateFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential</link:label>
    <link:label id="lab_efsc_ResidentialRealEstateFinancingReceivableMember_43e3b877-e92b-4220-b63f-4e3012f4f6a4_terseLabel_en-US" xlink:label="lab_efsc_ResidentialRealEstateFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential real estate</link:label>
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    <link:label id="lab_efsc_ResidentialRealEstateFinancingReceivableMember_documentation_en-US" xlink:label="lab_efsc_ResidentialRealEstateFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential Real Estate Financing Receivable [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_ResidentialRealEstateFinancingReceivableMember" xlink:href="efsc-20221231.xsd#efsc_ResidentialRealEstateFinancingReceivableMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_ResidentialRealEstateFinancingReceivableMember" xlink:to="lab_efsc_ResidentialRealEstateFinancingReceivableMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_84e5d646-acc1-4519-8fb6-67479665bab1_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Expected Term (years)</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeStockMember_184a333b-b8a5-4786-8091-1392e8d53f67_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock [Member]</link:label>
    <link:label id="lab_us-gaap_EmployeeStockMember_label_en-US" xlink:label="lab_us-gaap_EmployeeStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeStockMember" xlink:to="lab_us-gaap_EmployeeStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount_6c88300c-4f1b-4d31-a53a-b4b5c5374973_terseLabel_en-US" xlink:label="lab_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum balance outstanding at any month-end</link:label>
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    <link:label id="lab_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount_documentation_en-US" xlink:label="lab_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term and Long-term Debt, Maximum Month-end Outstanding Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" xlink:href="efsc-20221231.xsd#efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" xlink:to="lab_efsc_ShortTermAndLongTermDebtMaximumMonthEndOutstandingAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_ICSDeposits_91616119-5d9e-4e19-af0f-6b20066278bb_terseLabel_en-US" xlink:label="lab_efsc_ICSDeposits" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">ICS Deposits</link:label>
    <link:label id="lab_efsc_ICSDeposits_label_en-US" xlink:label="lab_efsc_ICSDeposits" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">ICS Deposits</link:label>
    <link:label id="lab_efsc_ICSDeposits_documentation_en-US" xlink:label="lab_efsc_ICSDeposits" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">ICS Deposits</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_ICSDeposits" xlink:to="lab_efsc_ICSDeposits" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_ConsumerAndOtherPortfolioSegmentMember_bd31aed9-d71c-4245-ab08-1bdbacf24900_verboseLabel_en-US" xlink:label="lab_efsc_ConsumerAndOtherPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_efsc_ConsumerAndOtherPortfolioSegmentMember_3dbf99aa-3348-44c4-8a00-fa7c66af566b_terseLabel_en-US" xlink:label="lab_efsc_ConsumerAndOtherPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_efsc_ConsumerAndOtherPortfolioSegmentMember_label_en-US" xlink:label="lab_efsc_ConsumerAndOtherPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consumer and Other Portfolio Segment [Member]</link:label>
    <link:label id="lab_efsc_ConsumerAndOtherPortfolioSegmentMember_documentation_en-US" xlink:label="lab_efsc_ConsumerAndOtherPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consumer and Other Portfolio Segment [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_ConsumerAndOtherPortfolioSegmentMember" xlink:href="efsc-20221231.xsd#efsc_ConsumerAndOtherPortfolioSegmentMember"/>
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    <link:label id="lab_efsc_LoansClassifiedByPerformingStatusMember_0437c190-e7d1-4c0f-a263-b23a904f866e_terseLabel_en-US" xlink:label="lab_efsc_LoansClassifiedByPerformingStatusMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Classified by Performing Status</link:label>
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    <link:label id="lab_efsc_LoansClassifiedByPerformingStatusMember_documentation_en-US" xlink:label="lab_efsc_LoansClassifiedByPerformingStatusMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Classified by Performing Status</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_LoansClassifiedByPerformingStatusMember" xlink:href="efsc-20221231.xsd#efsc_LoansClassifiedByPerformingStatusMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_LoansClassifiedByPerformingStatusMember" xlink:to="lab_efsc_LoansClassifiedByPerformingStatusMember" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_LoansClassifiedByRiskCategoryMember_62b4b335-39d4-4be5-97d2-b23a728d6c59_terseLabel_en-US" xlink:label="lab_efsc_LoansClassifiedByRiskCategoryMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Classified By Risk Category</link:label>
    <link:label id="lab_efsc_LoansClassifiedByRiskCategoryMember_label_en-US" xlink:label="lab_efsc_LoansClassifiedByRiskCategoryMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Classified By Risk Category [Member]</link:label>
    <link:label id="lab_efsc_LoansClassifiedByRiskCategoryMember_documentation_en-US" xlink:label="lab_efsc_LoansClassifiedByRiskCategoryMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Classified By Risk Category</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_LoansClassifiedByRiskCategoryMember" xlink:href="efsc-20221231.xsd#efsc_LoansClassifiedByRiskCategoryMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_LoansClassifiedByRiskCategoryMember" xlink:to="lab_efsc_LoansClassifiedByRiskCategoryMember" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable_d2b8f07c-4c14-4d89-8d46-c58824da3bf1_terseLabel_en-US" xlink:label="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Summary of Activity in the Allowance for Loan Losses by Portfolio Class and Category Based on Impairment Method [Table]</link:label>
    <link:label id="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable_label_en-US" xlink:label="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Summary of Activity in the Allowance for Loan Losses by Portfolio Class and Category Based on Impairment Method [Table]</link:label>
    <link:label id="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable_documentation_en-US" xlink:label="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Summary of Activity in the Allowance for Loan Losses by Portfolio Class and Category Based on Impairment Method [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" xlink:href="efsc-20221231.xsd#efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" xlink:to="lab_efsc_SummaryOfActivityInAllowanceForLoanLossesByPortfolioClassAndCategoryBasedOnImpairmentMethodTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTextBlock_0c7064d1-3470-4a9d-bc2a-0322095efbdb_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Actual Capital Amounts and Ratios</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTextBlock"/>
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    <link:label id="lab_dei_LocationDomain_371abd5f-5a02-4780-89e7-fcb497eef654_terseLabel_en-US" xlink:label="lab_dei_LocationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Location [Domain]</link:label>
    <link:label id="lab_dei_LocationDomain_label_en-US" xlink:label="lab_dei_LocationDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Location [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocationDomain" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocationDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LocationDomain" xlink:to="lab_dei_LocationDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_CurrentFiscalYearEndDate_6bd892d3-f8bf-4da9-b9b8-57b3d172bf5e_terseLabel_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:label id="lab_dei_CurrentFiscalYearEndDate_label_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CurrentFiscalYearEndDate" xlink:to="lab_dei_CurrentFiscalYearEndDate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeCollateralObligationToReturnSecurities_054a0343-3910-4faa-a86f-107f516e98d9_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeCollateralObligationToReturnSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, Collateral, Obligation to Return Securities</link:label>
    <link:label id="lab_us-gaap_DerivativeCollateralObligationToReturnSecurities_label_en-US" xlink:label="lab_us-gaap_DerivativeCollateralObligationToReturnSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, Collateral, Obligation to Return Securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeCollateralObligationToReturnSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities" xlink:to="lab_us-gaap_DerivativeCollateralObligationToReturnSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NotesReceivableGross_fe5e21f0-b251-42f4-96a8-0e9b2ac2a183_verboseLabel_en-US" xlink:label="lab_us-gaap_NotesReceivableGross" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans, before unearned loan fees</link:label>
    <link:label id="lab_us-gaap_NotesReceivableGross_cfd52fb6-25d6-4897-a534-149d71b97e08_terseLabel_en-US" xlink:label="lab_us-gaap_NotesReceivableGross" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable, before Allowance for Credit Loss</link:label>
    <link:label id="lab_us-gaap_NotesReceivableGross_8e902d9a-849b-440e-98f7-0022ba10f932_totalLabel_en-US" xlink:label="lab_us-gaap_NotesReceivableGross" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total</link:label>
    <link:label id="lab_us-gaap_NotesReceivableGross_label_en-US" xlink:label="lab_us-gaap_NotesReceivableGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable, before Allowance for Credit Loss</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesReceivableGross" xlink:to="lab_us-gaap_NotesReceivableGross" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FederalHomeLoanBankAdvancesBranchOfFHLBBankLineItems_e2a422eb-3b16-4f76-ad9b-2ff4c3cab932_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankAdvancesBranchOfFHLBBankLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank, Advances, Branch of FHLB [Line Items]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankAdvancesBranchOfFHLBBankLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesBranchOfFHLBBankLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FederalHomeLoanBankAdvancesBranchOfFHLBBankLineItems" xlink:to="lab_us-gaap_FederalHomeLoanBankAdvancesBranchOfFHLBBankLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_9b00fdd8-5983-4209-bb69-51e9494aad4a_terseLabel_en-US" xlink:label="lab_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Due after ten years</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount"/>
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    <link:label id="lab_us-gaap_StatementTable_ccca0413-3d82-45bd-b547-3ce0b2fba6eb_terseLabel_en-US" xlink:label="lab_us-gaap_StatementTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Table]</link:label>
    <link:label id="lab_us-gaap_StatementTable_label_en-US" xlink:label="lab_us-gaap_StatementTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementTable" xlink:to="lab_us-gaap_StatementTable" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_CustomerAnalysisExpenseMember_17db0092-5f81-453f-af25-376dbccff012_terseLabel_en-US" xlink:label="lab_efsc_CustomerAnalysisExpenseMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer Analysis Expense</link:label>
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    <link:label id="lab_efsc_CustomerAnalysisExpenseMember_documentation_en-US" xlink:label="lab_efsc_CustomerAnalysisExpenseMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer Analysis Expense</link:label>
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    <link:label id="lab_us-gaap_UndistributedEarnings_318a4093-3f5d-4f0f-ace1-24cf3a606dc4_terseLabel_en-US" xlink:label="lab_us-gaap_UndistributedEarnings" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity in undistributed earnings of subsidiaries</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
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    <link:label id="lab_efsc_FederalHomeLoanBankStockPolicyPolicyTextBlock_b9d81ae7-64bf-4ebb-8ade-c2f36082c369_terseLabel_en-US" xlink:label="lab_efsc_FederalHomeLoanBankStockPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Stock</link:label>
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    <link:label id="lab_efsc_OtherMiscellaneousIncomeMember_702ebd50-6911-495e-948e-426ff86c2388_terseLabel_en-US" xlink:label="lab_efsc_OtherMiscellaneousIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other income</link:label>
    <link:label id="lab_efsc_OtherMiscellaneousIncomeMember_label_en-US" xlink:label="lab_efsc_OtherMiscellaneousIncomeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Miscellaneous Income [Member]</link:label>
    <link:label id="lab_efsc_OtherMiscellaneousIncomeMember_documentation_en-US" xlink:label="lab_efsc_OtherMiscellaneousIncomeMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Miscellaneous Income</link:label>
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    <link:label id="lab_dei_EntityFileNumber_879ee6f7-19ae-4cf0-9355-7ebb82a73bcd_terseLabel_en-US" xlink:label="lab_dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity File Number</link:label>
    <link:label id="lab_dei_EntityFileNumber_label_en-US" xlink:label="lab_dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity File Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
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    <link:label id="lab_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm_098fa0f3-a877-48e8-8654-0363eeeb4f89_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FHLB advances</link:label>
    <link:label id="lab_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm_label_en-US" xlink:label="lab_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Expense, Federal Home Loan Bank and Federal Reserve Bank Advances, Long-term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseFederalHomeLoanBankAndFederalReserveBankAdvancesLongTerm"/>
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    <link:label id="lab_efsc_StateTaxCreditsHeldForSaleMember_e4accd27-d681-444c-87fd-d6d48d9b8555_terseLabel_en-US" xlink:label="lab_efsc_StateTaxCreditsHeldForSaleMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State tax credits, held for sale</link:label>
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    <link:label id="lab_efsc_StateTaxCreditsHeldForSaleMember_documentation_en-US" xlink:label="lab_efsc_StateTaxCreditsHeldForSaleMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State tax credits held for sale</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_StateTaxCreditsHeldForSaleMember" xlink:href="efsc-20221231.xsd#efsc_StateTaxCreditsHeldForSaleMember"/>
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    <link:label id="lab_efsc_ScheduleOfCommitmentsTableTextBlock_2e73f064-66f9-4506-a14d-f0696cf535d0_terseLabel_en-US" xlink:label="lab_efsc_ScheduleOfCommitmentsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Commitments</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_efsc_ScheduleOfCommitmentsTableTextBlock" xlink:href="efsc-20221231.xsd#efsc_ScheduleOfCommitmentsTableTextBlock"/>
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    <link:label id="lab_efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantExcludingDeferredShares_317f003c-7890-4450-8419-efc6f399baae_terseLabel_en-US" xlink:label="lab_efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantExcludingDeferredShares" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant, Excluding Deferred Shares</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantExcludingDeferredShares" xlink:href="efsc-20221231.xsd#efsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantExcludingDeferredShares"/>
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    <link:label id="lab_us-gaap_ScheduleOfSubordinatedBorrowingTextBlock_f9a1db3d-0e10-4890-a380-2a7e9fbf0aa6_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfSubordinatedBorrowingTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Subordinated Debentures</link:label>
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    <link:label id="lab_us-gaap_DividendIncomeOperating_0a1bcb6c-8270-4986-b67c-8e9dd325dc4d_verboseLabel_en-US" xlink:label="lab_us-gaap_DividendIncomeOperating" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends from Bank</link:label>
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    <link:label id="lab_efsc_ContractualMaturitiesTimeDeposits100000OrMoreAfterYearFive_3746de68-1338-4cb6-ac4a-ad0486b12564_terseLabel_en-US" xlink:label="lab_efsc_ContractualMaturitiesTimeDeposits100000OrMoreAfterYearFive" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 5 years</link:label>
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    <link:label id="lab_us-gaap_LineOfCredit_58ccce7d-ff32-4957-92da-978175faadcb_terseLabel_en-US" xlink:label="lab_us-gaap_LineOfCredit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount withdrawn</link:label>
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    <link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_acd5d615-94b6-4bbc-a219-0e0c28ebd824_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total liabilities</link:label>
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    <link:label id="lab_us-gaap_PaymentsOfStockIssuanceCosts_2542977e-b980-490e-9b39-995df2b6977a_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsOfStockIssuanceCosts" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Issuance cost</link:label>
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    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues_6a5b2745-07d5-420f-9761-eb08131f4c9d_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred stock issuance, net (in shares)</link:label>
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    <link:label id="lab_efsc_SubordinatedBorrowingBasisSpreadonVariableRate_e13718ac-1c62-497f-bdff-64ce1d411330_verboseLabel_en-US" xlink:label="lab_efsc_SubordinatedBorrowingBasisSpreadonVariableRate" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Floating interest rate</link:label>
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    <link:label id="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent_7819e533-a33c-4d1c-8f9b-e84b50953120_terseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts payable and other liabilities</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAndNoncurrent"/>
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    <link:label id="lab_us-gaap_PreferredStockDividendsAndOtherAdjustments_34427a7e-2dd9-4e4f-8621-689c9e655d48_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockDividendsAndOtherAdjustments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividends on preferred stock</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PreferredStockDividendsAndOtherAdjustments" xlink:to="lab_us-gaap_PreferredStockDividendsAndOtherAdjustments" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_A575Member_46c2b314-d920-41e7-9934-4833f8803f43_terseLabel_en-US" xlink:label="lab_efsc_A575Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">5.75%</link:label>
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    <link:label id="lab_efsc_A575Member_documentation_en-US" xlink:label="lab_efsc_A575Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">5.75%</link:label>
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    <link:label id="lab_efsc_BlanketLienMember_60682347-3279-43ba-af31-01bd85662a71_terseLabel_en-US" xlink:label="lab_efsc_BlanketLienMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Blanket Lien</link:label>
    <link:label id="lab_efsc_BlanketLienMember_label_en-US" xlink:label="lab_efsc_BlanketLienMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Blanket Lien [Member]</link:label>
    <link:label id="lab_efsc_BlanketLienMember_documentation_en-US" xlink:label="lab_efsc_BlanketLienMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Blanket Lien</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_BlanketLienMember" xlink:to="lab_efsc_BlanketLienMember" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_NumberOfBranchesClosed_1cfca848-1caa-4025-b225-868be438db49_terseLabel_en-US" xlink:label="lab_efsc_NumberOfBranchesClosed" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number Of Branches Closed</link:label>
    <link:label id="lab_efsc_NumberOfBranchesClosed_label_en-US" xlink:label="lab_efsc_NumberOfBranchesClosed" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number Of Branches Closed</link:label>
    <link:label id="lab_efsc_NumberOfBranchesClosed_documentation_en-US" xlink:label="lab_efsc_NumberOfBranchesClosed" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number Of Branches Closed</link:label>
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    <link:label id="lab_us-gaap_PerformanceSharesMember_f6557bef-9b78-466c-aab7-e358e369fd19_terseLabel_en-US" xlink:label="lab_us-gaap_PerformanceSharesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Performance Shares [Member]</link:label>
    <link:label id="lab_us-gaap_PerformanceSharesMember_label_en-US" xlink:label="lab_us-gaap_PerformanceSharesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Performance Shares [Member]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PerformanceSharesMember" xlink:to="lab_us-gaap_PerformanceSharesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember_15f6bfe3-af5e-43cf-929c-65571b0b3209_terseLabel_en-US" xlink:label="lab_efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Real Estate-Investor Owned Portfolio Segment [Member]</link:label>
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    <link:label id="lab_efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember_documentation_en-US" xlink:label="lab_efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Real Estate-Investor Owned Portfolio Segment [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember" xlink:href="efsc-20221231.xsd#efsc_CommercialRealEstateInvestorOwnedPortfolioSegmentMember"/>
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    <link:label id="lab_us-gaap_FinancialAssetNotPastDueMember_304b73d5-08a4-449d-85da-6e88397052be_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialAssetNotPastDueMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Asset, Not Past Due</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialAssetNotPastDueMember" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialAssetNotPastDueMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialAssetNotPastDueMember" xlink:to="lab_us-gaap_FinancialAssetNotPastDueMember" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_ContractualMaturitiesTimeDepositsLessThan100000AfterYearFive_98a3ad22-f376-4591-bd07-5c18d84b6337_terseLabel_en-US" xlink:label="lab_efsc_ContractualMaturitiesTimeDepositsLessThan100000AfterYearFive" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 5 years</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_efsc_ContractualMaturitiesTimeDepositsLessThan100000AfterYearFive" xlink:to="lab_efsc_ContractualMaturitiesTimeDepositsLessThan100000AfterYearFive" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_7884b9b2-5411-4af4-92ca-0bbe9b285b16_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated other comprehensive (loss) income, net</link:label>
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    <link:label id="lab_dei_EntityEmergingGrowthCompany_1a16913d-c562-4a81-848e-fa71fe2f4d31_terseLabel_en-US" xlink:label="lab_dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Emerging Growth Company</link:label>
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    <link:label id="lab_us-gaap_BorrowingsMember_ab21cfb0-a31c-4f50-9205-0b2a1f10d2e2_terseLabel_en-US" xlink:label="lab_us-gaap_BorrowingsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Borrowings</link:label>
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    <link:label id="lab_efsc_MergerRelatedExpenses_documentation_en-US" xlink:label="lab_efsc_MergerRelatedExpenses" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Merger Related Expenses</link:label>
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    <link:label id="lab_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure_749f8f40-5289-4fa4-9729-a1bc8d615ba2_terseLabel_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FHLB advances</link:label>
    <link:label id="lab_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal Home Loan Bank Borrowings, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalHomeLoanBankBorrowingsFairValueDisclosure"/>
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    <link:label id="lab_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_2d1a1b80-ef5e-4a3f-b00b-27d930dc8fa8_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Unrealized Losses</link:label>
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    <link:label id="lab_us-gaap_PaymentsForProceedsFromLoansAndLeases_20464acf-94b5-4c82-9719-301afba62a47_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForProceedsFromLoansAndLeases" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net (increase) decrease in loans</link:label>
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    <link:label id="lab_us-gaap_CommonStockMember_2031ea23-5fae-44f9-b08a-dddf39cfaa5b_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common</link:label>
    <link:label id="lab_us-gaap_CommonStockMember_label_en-US" xlink:label="lab_us-gaap_CommonStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
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    <link:label id="lab_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_b3851f98-fbac-4450-93f7-e077968408a9_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other borrowings</link:label>
    <link:label id="lab_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_label_en-US" xlink:label="lab_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Expense, Federal Funds Purchased and Securities Sold under Agreements to Repurchase</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseFederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
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    <link:label id="lab_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_84409c90-d550-43ca-93b9-14c0724f251b_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Recorded Investment With No Allowance</link:label>
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    <link:label id="lab_efsc_NoncoveredLoansMember_e672b8b6-db48-4fc9-995c-bbd5e0133ef5_terseLabel_en-US" xlink:label="lab_efsc_NoncoveredLoansMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Covered Loans</link:label>
    <link:label id="lab_efsc_NoncoveredLoansMember_label_en-US" xlink:label="lab_efsc_NoncoveredLoansMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Noncovered Loans [Member]</link:label>
    <link:label id="lab_efsc_NoncoveredLoansMember_documentation_en-US" xlink:label="lab_efsc_NoncoveredLoansMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Noncovered Loans [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_NoncoveredLoansMember" xlink:href="efsc-20221231.xsd#efsc_NoncoveredLoansMember"/>
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    <link:label id="lab_us-gaap_ProfessionalFees_d319c3e9-095c-4ad0-b696-64392b11c306_terseLabel_en-US" xlink:label="lab_us-gaap_ProfessionalFees" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Professional fees</link:label>
    <link:label id="lab_us-gaap_ProfessionalFees_label_en-US" xlink:label="lab_us-gaap_ProfessionalFees" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Professional Fees</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfessionalFees"/>
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    <link:label id="lab_us-gaap_FinancialServiceOtherMember_89df169b-9693-464b-ae1a-13c8aff01c1d_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialServiceOtherMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total other noninterest income</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialServiceOtherMember" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancialServiceOtherMember"/>
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    <link:label id="lab_us-gaap_FinancingReceivablesPeriodPastDueAxis_b7baf899-eeb6-4cad-a80d-030f7f00f823_terseLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Asset, Aging [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancingReceivablesPeriodPastDueAxis_label_en-US" xlink:label="lab_us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Asset, Aging [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis"/>
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    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c914d3dc-e026-44ec-88a7-819a34d82bab_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross Unrealized Losses</link:label>
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    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_19b9effe-0abe-4a72-9860-35289d2905a2_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2022</link:label>
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    <link:label id="lab_dei_EntityAddressCityOrTown_2d2d8ac5-12a0-4c5b-9813-2854ffa82436_terseLabel_en-US" xlink:label="lab_dei_EntityAddressCityOrTown" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, City or Town</link:label>
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    <link:label id="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock_d2a598dd-5b5e-4f33-82f4-c680c19254b6_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_NoncashInvestingAndFinancingItemsAbstract_4e6b4706-ec90-476c-b43d-1b3ad9aa803a_terseLabel_en-US" xlink:label="lab_us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Noncash investing and financing transactions:</link:label>
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    <link:label id="lab_us-gaap_PerformingFinancingReceivableMember_9a8a42f0-49ee-4f9d-b7d3-5b2b41c660b9_terseLabel_en-US" xlink:label="lab_us-gaap_PerformingFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Performing</link:label>
    <link:label id="lab_us-gaap_PerformingFinancingReceivableMember_label_en-US" xlink:label="lab_us-gaap_PerformingFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Performing Financial Instruments [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformingFinancingReceivableMember" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PerformingFinancingReceivableMember"/>
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    <link:label id="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_cc48711a-62cb-4d8d-a64b-893dc00839ca_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Unrecognized Tax Benefits</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock"/>
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    <link:label id="lab_us-gaap_InterestIncomeMember_1e2194d9-8779-4738-a572-6fffc4767fee_terseLabel_en-US" xlink:label="lab_us-gaap_InterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income</link:label>
    <link:label id="lab_us-gaap_InterestIncomeMember_label_en-US" xlink:label="lab_us-gaap_InterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Income [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeMember" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeMember"/>
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    <link:label id="lab_us-gaap_SubordinatedBorrowingsAbstract_f69b40ef-9ab2-4372-bc54-2b4209f4677f_terseLabel_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Borrowings [Abstract]</link:label>
    <link:label id="lab_us-gaap_SubordinatedBorrowingsAbstract_label_en-US" xlink:label="lab_us-gaap_SubordinatedBorrowingsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subordinated Borrowings [Abstract]</link:label>
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    <link:label id="lab_efsc_AmortizationOfServicingAssets_4a14deb3-3e89-41c0-aa98-dfe0e6e7c8b5_terseLabel_en-US" xlink:label="lab_efsc_AmortizationOfServicingAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization of servicing assets</link:label>
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    <link:label id="lab_us-gaap_BalanceSheetLocationAxis_f52624da-9177-4669-89b7-3cbdf231d8cf_terseLabel_en-US" xlink:label="lab_us-gaap_BalanceSheetLocationAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance Sheet Location [Axis]</link:label>
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    <link:label id="lab_efsc_FinancingReceivablePaycheckProtectionProgramNetOfDeferredFees_0d783927-5b2f-46d8-9c79-51b91b662127_terseLabel_en-US" xlink:label="lab_efsc_FinancingReceivablePaycheckProtectionProgramNetOfDeferredFees" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">financing receivable, paycheck protection program, net of deferred fees</link:label>
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    <link:label id="lab_efsc_FinancingReceivablePaycheckProtectionProgramNetOfDeferredFees_documentation_en-US" xlink:label="lab_efsc_FinancingReceivablePaycheckProtectionProgramNetOfDeferredFees" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">financing receivable, paycheck protection program, net of deferred fees</link:label>
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    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_f6b065cb-a71a-4c2f-b5cb-5e0a1a5580e9_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Frequency [Domain]</link:label>
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    <link:label id="lab_us-gaap_InterestExpense_734f5b64-234f-43c9-91d7-ee96a6438282_totalLabel_en-US" xlink:label="lab_us-gaap_InterestExpense" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total interest expense</link:label>
    <link:label id="lab_us-gaap_InterestExpense_label_en-US" xlink:label="lab_us-gaap_InterestExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestExpense" xlink:to="lab_us-gaap_InterestExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InterestAndDividendIncomeOperating_399d95bb-7dd4-4d0e-b948-d2474256df01_totalLabel_en-US" xlink:label="lab_us-gaap_InterestAndDividendIncomeOperating" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total interest income</link:label>
    <link:label id="lab_us-gaap_InterestAndDividendIncomeOperating_label_en-US" xlink:label="lab_us-gaap_InterestAndDividendIncomeOperating" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest and Dividend Income, Operating</link:label>
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    <link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_3fef8b79-999b-4f81-9a68-34af2c0b94b8_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average interest rate at December 31</link:label>
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    <link:label id="lab_us-gaap_InformationTechnologyAndDataProcessing_26ce8155-c47d-4edf-a8db-f84fbe324644_terseLabel_en-US" xlink:label="lab_us-gaap_InformationTechnologyAndDataProcessing" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Data processing</link:label>
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    <link:label id="lab_us-gaap_OperatingLeaseLeaseIncomeLeasePayments_12934746-3819-4cf4-bd55-c75b4af68806_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeaseLeaseIncomeLeasePayments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Lease, Lease Income, Lease Payments</link:label>
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    <link:label id="lab_us-gaap_InterestAndFeeIncomeLoansAndLeases_172e7031-5b51-4e81-87b5-36498e100865_terseLabel_en-US" xlink:label="lab_us-gaap_InterestAndFeeIncomeLoansAndLeases" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans</link:label>
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    <link:label id="lab_efsc_AccruedInterestReceivableHeldToMaturitySecurities_10ff9ef9-b661-4c10-b13e-0894089f0171_terseLabel_en-US" xlink:label="lab_efsc_AccruedInterestReceivableHeldToMaturitySecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">accrued interest receivable, held to maturity securities</link:label>
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    <link:label id="lab_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_69963d42-a64c-4c80-afa7-0c30a05f60d9_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lessee, Operating Lease, Liability, Payments, Due after Year Five</link:label>
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    <link:label id="lab_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_14cb79b3-35b4-4687-a41f-4e16468ecc9b_terseLabel_en-US" xlink:label="lab_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reclassification out of Accumulated Other Comprehensive Income [Table]</link:label>
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    <link:label id="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearTwo_97ab0167-46c1-4eff-97c2-c979c43a386b_terseLabel_en-US" xlink:label="lab_efsc_InterestBearingDomesticDepositOtherTimeDepositYearTwo" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 1 year and less than 2 years</link:label>
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    <link:label id="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract_c9b1918e-9a67-475f-8203-23b75b134b3d_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings per common share</link:label>
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    <link:label id="lab_us-gaap_TimeDepositMaturitiesYearTwo_fac738cc-f17e-4ccb-af12-b2dabecadeff_totalLabel_en-US" xlink:label="lab_us-gaap_TimeDepositMaturitiesYearTwo" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Greater than 1 year and less than 2 years</link:label>
    <link:label id="lab_us-gaap_TimeDepositMaturitiesYearTwo_label_en-US" xlink:label="lab_us-gaap_TimeDepositMaturitiesYearTwo" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Time Deposit Maturities, Year Two</link:label>
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    <link:label id="lab_us-gaap_LaborAndRelatedExpense_29ab4c8e-65b0-4011-ba40-f26763ff82d0_terseLabel_en-US" xlink:label="lab_us-gaap_LaborAndRelatedExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee compensation and benefits</link:label>
    <link:label id="lab_us-gaap_LaborAndRelatedExpense_label_en-US" xlink:label="lab_us-gaap_LaborAndRelatedExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Labor and Related Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LaborAndRelatedExpense" xlink:to="lab_us-gaap_LaborAndRelatedExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_cff8831c-b13a-4c93-831c-87845e84d3d1_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments [Domain]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments [Domain]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember" xlink:to="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_58b6de90-c8e4-41cf-82a0-cf1b3a8356a3_terseLabel_en-US" xlink:label="lab_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">&#160;&#160;&#160;&#160;Obligations of U.S. Government-sponsored enterprises</link:label>
    <link:label id="lab_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember_label_en-US" xlink:label="lab_us-gaap_USGovernmentSponsoredEnterprisesDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Government-sponsored Enterprises Debt Securities [Member]</link:label>
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    <link:label id="lab_efsc_Sharesissuedinconnectionwithacquisition_7a2ec004-e589-4dd5-8e78-4c21ee29b8eb_terseLabel_en-US" xlink:label="lab_efsc_Sharesissuedinconnectionwithacquisition" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares issued in connection with acquisition</link:label>
    <link:label id="lab_efsc_Sharesissuedinconnectionwithacquisition_label_en-US" xlink:label="lab_efsc_Sharesissuedinconnectionwithacquisition" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares issued in connection with acquisition</link:label>
    <link:label id="lab_efsc_Sharesissuedinconnectionwithacquisition_documentation_en-US" xlink:label="lab_efsc_Sharesissuedinconnectionwithacquisition" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares issued in connection with acquisition</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_efsc_Sharesissuedinconnectionwithacquisition" xlink:href="efsc-20221231.xsd#efsc_Sharesissuedinconnectionwithacquisition"/>
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    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_19657bfc-a723-493b-a754-f780695c790d_periodStartLabel_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and cash equivalents, beginning of period</link:label>
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    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_label_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_62ba3c46-3b83-44ff-a1be-bfe3eee4ae4a_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Derivative Instruments</link:label>
    <link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Derivative Instruments [Table Text Block]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TransferToOtherRealEstate_d50d6944-b131-436d-a456-e1e628be6aca_terseLabel_en-US" xlink:label="lab_us-gaap_TransferToOtherRealEstate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Real Estate Owned, Transfer to Real Estate Owned</link:label>
    <link:label id="lab_us-gaap_TransferToOtherRealEstate_label_en-US" xlink:label="lab_us-gaap_TransferToOtherRealEstate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Real Estate Owned, Transfer to Real Estate Owned</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferToOtherRealEstate" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TransferToOtherRealEstate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TransferToOtherRealEstate" xlink:to="lab_us-gaap_TransferToOtherRealEstate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_f7431fd2-0029-4ffc-8e74-673301914535_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, par value</link:label>
    <link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_label_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Par or Stated Value Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockParOrStatedValuePerShare" xlink:to="lab_us-gaap_CommonStockParOrStatedValuePerShare" xlink:type="arc" order="1"/>
    <link:label id="lab_efsc_BankOwnedLifeInsuranceMember_76c0fe62-87ce-4bee-95d4-5c5ec8dc6ed8_terseLabel_en-US" xlink:label="lab_efsc_BankOwnedLifeInsuranceMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bank-owned life insurance</link:label>
    <link:label id="lab_efsc_BankOwnedLifeInsuranceMember_label_en-US" xlink:label="lab_efsc_BankOwnedLifeInsuranceMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bank-Owned Life Insurance [Member]</link:label>
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    <link:label id="lab_efsc_ShortTermAndLongTermDebtAverageOutstandingAmount_63dd2e09-2a08-43a9-942a-0fe1090fc609_terseLabel_en-US" xlink:label="lab_efsc_ShortTermAndLongTermDebtAverageOutstandingAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average balance during the year</link:label>
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    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_066f88c3-645a-46db-9437-b0b5acfdcf8c_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
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    <link:label id="lab_us-gaap_BuildingsAndImprovementsGross_a79970bb-a04f-43b7-8c1c-9eee75beb16c_terseLabel_en-US" xlink:label="lab_us-gaap_BuildingsAndImprovementsGross" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Buildings and leasehold improvements</link:label>
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    <link:label id="lab_efsc_BasisOfAccountingAndConsolidationPolicyPolicyTextBlock_d675b888-758c-4214-a266-bd85e8c73d6c_terseLabel_en-US" xlink:label="lab_efsc_BasisOfAccountingAndConsolidationPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business and Consolidation</link:label>
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    <link:label id="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseCharitableContributions_d244acd0-eb3f-4993-bc1c-fa1715f68885_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseCharitableContributions" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-taxable donation to charitable foundation</link:label>
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    <link:label id="lab_efsc_A2018StockIncentivePlanMember_73dd8408-381f-4bbc-a07e-ea3f37653404_terseLabel_en-US" xlink:label="lab_efsc_A2018StockIncentivePlanMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2018 Stock Incentive Plan [Member]</link:label>
    <link:label id="lab_efsc_A2018StockIncentivePlanMember_label_en-US" xlink:label="lab_efsc_A2018StockIncentivePlanMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2018 Stock Incentive Plan [Member]</link:label>
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    <link:label id="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_447ff9ab-5fbf-40e7-ad29-6553466ab916_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax expense at statutory rate</link:label>
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    <link:label id="lab_efsc_AmortizationExpenseMember_a549d63f-4bf3-4276-aa5a-4693ae095153_terseLabel_en-US" xlink:label="lab_efsc_AmortizationExpenseMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization Expense</link:label>
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    <link:label id="lab_efsc_AmortizationExpenseMember_documentation_en-US" xlink:label="lab_efsc_AmortizationExpenseMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization Expense</link:label>
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    <link:label id="lab_us-gaap_FinancingReceivableAllowanceForCreditLosses_1b170315-8646-4c10-a22b-d80ec3f537d8_periodStartLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivableAllowanceForCreditLosses" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance, beginning of year</link:label>
    <link:label id="lab_us-gaap_FinancingReceivableAllowanceForCreditLosses_ec782054-243d-46a0-a743-dd2c6aaa7a7a_periodEndLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivableAllowanceForCreditLosses" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance, end of year</link:label>
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    <link:label id="lab_us-gaap_PreferredStockMember_a6807bf8-63d0-44b2-be98-ca17bbf5f446_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred</link:label>
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    <link:label id="lab_us-gaap_ProceedsFromInterestAndDividendsReceived_be94ec74-b3cc-4d41-baa5-974caf4558ef_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromInterestAndDividendsReceived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from distributions on other investments</link:label>
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_fb88292b-74ef-4d73-9a93-1c1ca2e004f0_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Due after ten years</link:label>
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