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v3.21.2

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Operating activities |  |
Net loss | $ (215,320) | $ (173,749)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 6,499 | 6,410
Stock–based compensation expense | 63,162 | 36,521
Net amortization of premiums (discounts) on marketable securities | 6,316 | (1,074)
Non-cash adjustment to operating lease expense | (2,201) | (1,669)
Other non-cash items | 0 | 18
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | 8,049 | 3,819
Accounts payable | 3,783 | 147
Accruals and other current liabilities | (3,036) | 4,880
Contract liabilities | (10,601) | (17,920)
Related party contract liability | (2,546) | 44,854
Net cash used in operating activities | (145,895) | (97,763)
Investing activities |  |
Purchases of marketable securities | (1,191,491) | (687,523)
Purchases of property and equipment | (5,447) | (1,900)
Maturities and sales of marketable securities | 1,216,062 | 433,557
Net cash provided by (used in) investing activities | 19,124 | (255,866)
Financing activities |  |
Proceeds from issuance of common stock in connection with Collaboration Agreements | 0 | 420,146
Proceeds from public offering of common stock, net of issuance costs | 0 | 193,948
Proceeds from exercise of awards under equity incentive plans | 14,180 | 11,133
Net cash provided by financing activities | 14,180 | 625,227
Net increase (decrease) in cash, cash equivalents and restricted cash | (112,591) | 271,598
Cash, cash equivalents and restricted cash at beginning of period | 508,644 | 80,949
Cash, cash equivalents and restricted cash at end of period | 396,053 | 352,547
Supplemental disclosures of cash flow information |  |
Property and equipment purchases accrued but not yet paid | $ 29 | $ 32

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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from issuance of shares under share-based payment arrangement. Includes, but is not limited to, option exercised. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=120381028&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References No definition available. + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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