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Marketable Securities (Tables)
9 Months Ended
Sep. 30, 2021
Investments, Debt and Equity Securities [Abstract]  
Summary of Available for Sale Securities The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s marketable securities by major security type at each balance sheet date are summarized in the tables below (in thousands):
September 30, 2021
Amortized CostUnrealized Holding GainsUnrealized Holding LossesAggregate Fair Value
Short-term marketable securities:
U.S. government treasuries(1)
$472,214 $13 $(13)$472,214 
U.S. government agency securities
15,003 — — 15,003 
Corporate debt securities(2)
61,187 (10)61,182 
Commercial paper
96,223 — — 96,223 
Total short-term marketable securities
644,627 18 (23)644,622 
Long-term marketable securities:
U.S. government treasuries(3)
299,225 17 (173)299,069 
Corporate debt securities(4)
20,413 (12)20,403 
Total long-term marketable securities
319,638 19 (185)319,472 
Total
$964,265 $37 $(208)$964,094 
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(1)Unrealized holding losses on 7 securities with an aggregate fair value of $271.8 million.
(2)Unrealized holding losses on 8 securities with an aggregate fair value of $27.8 million.
(3)Unrealized holding losses on 11 securities with an aggregate fair value of $251.5 million.
(4)Unrealized holding losses on 5 securities with an aggregate fair value of $16.8 million.

December 31, 2020
Amortized CostUnrealized Holding GainsUnrealized Holding LossesAggregate Fair Value
Short-term marketable securities:
U.S. government treasuries(1)
$878,906 $44 $(12)$878,938 
U.S. government agency securities(2)
25,214 (2)25,217 
Corporate debt securities
27,101 79 — 27,180 
Commercial paper
31,218 — — 31,218 
Total short-term marketable securities
962,439 128 (14)962,553 
Long-term marketable securities:
U.S. government treasuries
2,561 — — 2,561 
Corporate debt securities(3)
30,147 (11)30,138 
Total long-term marketable securities
32,708 (11)32,699 
Total
$995,147 $130 $(25)$995,252 
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(1)Unrealized holding losses on 19 securities with an aggregate fair value of $369.9 million.
(2)Unrealized holding losses on 2 securities with an aggregate fair value of $10.1 million.
(3)Unrealized holding losses on 1 security with an aggregate fair value of $20.1 million.