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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Operating activities    
Net loss $ (215,320) $ (173,749)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 6,499 6,410
Stock–based compensation expense 63,162 36,521
Net amortization of premiums (discounts) on marketable securities 6,316 (1,074)
Non-cash adjustment to operating lease expense (2,201) (1,669)
Other non-cash items 0 18
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 8,049 3,819
Accounts payable 3,783 147
Accruals and other current liabilities (3,036) 4,880
Contract liabilities (10,601) (17,920)
Related party contract liability (2,546) 44,854
Net cash used in operating activities (145,895) (97,763)
Investing activities    
Purchases of marketable securities (1,191,491) (687,523)
Purchases of property and equipment (5,447) (1,900)
Maturities and sales of marketable securities 1,216,062 433,557
Net cash provided by (used in) investing activities 19,124 (255,866)
Financing activities    
Proceeds from issuance of common stock in connection with Collaboration Agreements 0 420,146
Proceeds from public offering of common stock, net of issuance costs 0 193,948
Proceeds from exercise of awards under equity incentive plans 14,180 11,133
Net cash provided by financing activities 14,180 625,227
Net increase (decrease) in cash, cash equivalents and restricted cash (112,591) 271,598
Cash, cash equivalents and restricted cash at beginning of period 508,644 80,949
Cash, cash equivalents and restricted cash at end of period 396,053 352,547
Supplemental disclosures of cash flow information    
Property and equipment purchases accrued but not yet paid $ 29 $ 32