<SEC-DOCUMENT>0001209191-21-038043.txt : 20210603
<SEC-HEADER>0001209191-21-038043.hdr.sgml : 20210603
<ACCEPTANCE-DATETIME>20210603205540
ACCESSION NUMBER:		0001209191-21-038043
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210322
FILED AS OF DATE:		20210603
DATE AS OF CHANGE:		20210603

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			NELSEN ROBERT
		CENTRAL INDEX KEY:			0001219042

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38311
		FILM NUMBER:		21994548

	MAIL ADDRESS:	
		STREET 1:		8755 W. HIGGINS ROAD
		STREET 2:		SUITE 1025
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60631

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Denali Therapeutics Inc.
		CENTRAL INDEX KEY:			0001714899
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				463872213
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(650) 866-8548

	MAIL ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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        <issuerName>Denali Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>DNLI</issuerTradingSymbol>
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            <rptOwnerName>NELSEN ROBERT</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ARCH VENTURE PARTNERS</rptOwnerStreet1>
            <rptOwnerStreet2>8755 W. HIGGINS ROAD, SUITE 1025</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60631</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
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    <nonDerivativeTable>
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                <transactionPricePerShare>
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                <transactionPricePerShare>
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                <sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
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            <securityTitle>
                <value>Common Stock</value>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
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            <transactionTimeliness>
                <value></value>
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                    <value>3253</value>
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                <transactionPricePerShare>
                    <value>0.00</value>
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        <derivativeTransaction>
            <securityTitle>
                <value>Restricted Stock Units</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F6"/>
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                <value>2021-06-01</value>
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                    <value>D</value>
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            <exerciseDate>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F7"/>
            </expirationDate>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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    <footnotes>
        <footnote id="F1">Distribution of Common Stock held by a limited partnership to its partners for no consideration.</footnote>
        <footnote id="F2">Reflects change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.</footnote>
        <footnote id="F3">The sole general partner of ARCH Venture Fund VIII, L.P. (&quot;ARCH Fund VIII&quot;) is ARCH Venture Partners VIII, L.P. (&quot;ARCH Partners VIII&quot;). The sole general partner of ARCH Partners VIII is ARCH Venture Partners VIII, LLC (&quot;ARCH VIII LLC&quot;). ARCH Partners VIII may therefore be deemed to beneficially own the securities held by ARCH Fund VIII and ARCH VIII LLC may be deemed to beneficially own the securities held by ARCH Fund VIII. ARCH Partners VIII and ARCH VIII LLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein. The Reporting Person is a managing director of ARCH VIII LLC and may be deemed to beneficially own the shares held by ARCH Fund VIII. Mr. Nelsen disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.</footnote>
        <footnote id="F4">Following the reported transactions, 10,168,749 shares of common stock were held of record by ARCH Fund VIII.</footnote>
        <footnote id="F5">Following the reported transactions, 9,668,749 shares of common stock were held of record by ARCH Fund VIII.</footnote>
        <footnote id="F6">Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.</footnote>
        <footnote id="F7">100% of the restricted stock units shall vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Tyler Nielsen, by power of attorney</signatureName>
        <signatureDate>2021-06-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
