<SEC-DOCUMENT>0001714899-22-000043-index.html : 20220217
<SEC-HEADER>0001714899-22-000043.hdr.sgml : 20220217
<ACCEPTANCE-DATETIME>20220217202524
ACCESSION NUMBER:		0001714899-22-000043
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20211231
FILED AS OF DATE:		20220217
DATE AS OF CHANGE:		20220217

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Tessier-Lavigne Marc
		CENTRAL INDEX KEY:			0001437435

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38311
		FILM NUMBER:		22650474

	MAIL ADDRESS:	
		STREET 1:		1 DNA WAY
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Denali Therapeutics Inc.
		CENTRAL INDEX KEY:			0001714899
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				463872213
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(650) 866-8548

	MAIL ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>wf-form5_164514750112269.xml
<DESCRIPTION>FORM 5
<TEXT>
Document 1 - file: wf-form5_164514750112269.html

Document 1 - RAW XML: wf-form5_164514750112269.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>poa.htm
<DESCRIPTION>POWER OF ATTORNEY FOR: /S/ TYLER NIELSEN, BY POWER OF ATTORNEY
<TEXT>
Document 2 - file: poa.htm

</DOCUMENT>
</SEC-DOCUMENT>