<SEC-DOCUMENT>0001628280-22-026763-index.html : 20221020
<SEC-HEADER>0001628280-22-026763.hdr.sgml : 20221020
<ACCEPTANCE-DATETIME>20221020165744
ACCESSION NUMBER:		0001628280-22-026763
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		14
FILED AS OF DATE:		20221020
DATE AS OF CHANGE:		20221020

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Denali Therapeutics Inc.
		CENTRAL INDEX KEY:			0001714899
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				463872213
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-263107
		FILM NUMBER:		221321625

	BUSINESS ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(650) 866-8548

	MAIL ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>denaliprosupp424b5final.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: denaliprosupp424b5final.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>2
<FILENAME>exhibit107-prosupp424b5fin.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 2 - file: exhibit107-prosupp424b5fin.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>dnlilogoa01a.jpg
<TEXT>
Document 3 - file: dnlilogoa01a.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>etv3a1.jpg
<TEXT>
Document 4 - file: etv3a1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>figure10.jpg
<TEXT>
Document 5 - file: figure10.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>figure11.jpg
<TEXT>
Document 6 - file: figure11.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>figure2.jpg
<TEXT>
Document 7 - file: figure2.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>figure3.jpg
<TEXT>
Document 8 - file: figure3.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>figure5.jpg
<TEXT>
Document 9 - file: figure5.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>figure8.jpg
<TEXT>
Document 10 - file: figure8.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>figure9.jpg
<TEXT>
Document 11 - file: figure9.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>image1.jpg
<TEXT>
Document 12 - file: image1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>image_2.jpg
<TEXT>
Document 13 - file: image_2.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>14
<FILENAME>picture4.jpg
<TEXT>
Document 14 - file: picture4.jpg

</DOCUMENT>
</SEC-DOCUMENT>