    <SEC-DOCUMENT>0001714899-23-000064-index.html : 20230418
    <SEC-HEADER>0001714899-23-000064.hdr.sgml : 20230418
    <ACCEPTANCE-DATETIME>20230418160547
    ACCESSION NUMBER:		0001714899-23-000064
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230418
    DATE AS OF CHANGE:		20230418
    EFFECTIVENESS DATE:		20230418

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Denali Therapeutics Inc.
    		CENTRAL INDEX KEY:			0001714899
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				463872213
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-38311
    		FILM NUMBER:		23826859

    	BUSINESS ADDRESS:
    		STREET 1:		161 OYSTER POINT BLVD.
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    		BUSINESS PHONE:		(650) 866-8548

    	MAIL ADDRESS:
    		STREET 1:		161 OYSTER POINT BLVD.
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>fy22denaliannualreport.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: fy22denaliannualreport.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>