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v3.25.2

Segment Information (Details) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2025 USD ($) | Jun. 30, 2024 USD ($) | Jun. 30, 2025 USD ($) segment | Jun. 30, 2024 USD ($)
Segment Reporting [Abstract] |  |  |  |
Number of operating segments | segment |  |  | 1 |
Expenses |  |  |  |
Total research and development expenses | $ 102,696 | $ 91,399 | $ 218,923 | $ 198,415
Total general and administrative expenses | 32,267 | 25,194 | 61,620 | 50,430
Total operating expenses | 134,963 | 116,593 | 280,543 | 248,845
Segment gain from divestiture of small molecule programs | 0 | 0 | 0 | 14,537
Loss from operations | (134,963) | (116,593) | (280,543) | (234,308)
Segment interest and other income, net | 10,844 | 17,567 | 23,454 | 33,480
Therapeutics Segment |  |  |  |
Expenses |  |  |  |
Other research and development expenses | 22,060 | 14,504 | 42,706 | 30,386
Personnel related research and development expenses | 40,255 | 34,052 | 80,524 | 76,381
Total research and development expenses | 102,696 | 91,399 | 218,923 | 198,415
Personnel related general and administrative expenses | 20,115 | 17,105 | 38,853 | 36,190
Other general and administrative expenses | 12,152 | 8,089 | 22,767 | 14,240
Total general and administrative expenses | 32,267 | 25,194 | 61,620 | 50,430
Total operating expenses | 134,963 | 116,593 | 280,543 | 248,845
Segment gain from divestiture of small molecule programs | 0 | 0 | 0 | 14,537
Loss from operations | (134,963) | (116,593) | (280,543) | (234,308)
Segment interest and other income, net | 10,844 | 17,567 | 23,454 | 33,480
Loss before income taxes | (124,119) | (99,026) | (257,089) | (200,828)
Therapeutics Segment | TV Programs, Including Cost Sharing |  |  |  |
Expenses |  |  |  |
External research and development expense | 37,594 | 30,247 | 84,052 | 65,931
Therapeutics Segment | Small Molecule Programs, Including Cost Sharing |  |  |  |
Expenses |  |  |  |
External research and development expense | $ 2,787 | $ 12,596 | $ 11,641 | $ 25,717

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