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Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2023   138,385,498      
Beginning balance at Dec. 31, 2023 $ 1,030,954 $ 1,711 $ 2,144,811 $ 643 $ (1,116,211)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock and pre-funded warrants, net of issuance costs of $480 (in shares)   3,244,689      
Issuance of common stock and pre-funded warrants, net of issuance costs of $480 499,253 $ 32 499,221    
Issuances under equity incentive plans (in shares)   657,522      
Issuances under equity incentive plans 7,778 $ 7 7,771    
Vesting of restricted stock units (in shares)   835,873      
Vesting of restricted stock units 0 $ 7 (7)    
Stock-based compensation 53,196   53,196    
Net loss (200,828)       (200,828)
Other comprehensive loss (3,302)     (3,302)  
Ending balance (in shares) at Jun. 30, 2024   143,123,582      
Ending balance at Jun. 30, 2024 1,387,051 $ 1,757 2,704,992 (2,659) (1,317,039)
Beginning balance (in shares) at Mar. 31, 2024   142,512,856      
Beginning balance at Mar. 31, 2024 1,455,475 $ 1,751 2,673,033 (1,296) (1,218,013)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuances under equity incentive plans (in shares)   527,308      
Issuances under equity incentive plans 6,755 $ 5 6,750    
Vesting of restricted stock units (in shares)   83,418      
Vesting of restricted stock units 0 $ 1 (1)    
Stock-based compensation 25,210   25,210    
Net loss (99,026)       (99,026)
Other comprehensive loss (1,363)     (1,363)  
Ending balance (in shares) at Jun. 30, 2024   143,123,582      
Ending balance at Jun. 30, 2024 $ 1,387,051 $ 1,757 2,704,992 (2,659) (1,317,039)
Beginning balance (in shares) at Dec. 31, 2024 144,220,986 144,220,986      
Beginning balance at Dec. 31, 2024 $ 1,229,684 $ 1,768 2,764,880 2,020 (1,538,984)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuances under equity incentive plans (in shares)   455,335      
Issuances under equity incentive plans 4,652 $ 5 4,647    
Vesting of restricted stock units (in shares)   1,009,121      
Vesting of restricted stock units 0 $ 10 (10)    
Stock-based compensation 50,887   50,887    
Net loss (257,089)       (257,089)
Other comprehensive loss $ (1,081)     (1,081)  
Ending balance (in shares) at Jun. 30, 2025 145,685,442 145,685,442      
Ending balance at Jun. 30, 2025 $ 1,027,053 $ 1,783 2,820,404 939 (1,796,073)
Beginning balance (in shares) at Mar. 31, 2025   145,251,258      
Beginning balance at Mar. 31, 2025 1,122,686 $ 1,778 2,790,825 2,037 (1,671,954)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuances under equity incentive plans (in shares)   341,543      
Issuances under equity incentive plans 4,057 $ 4 4,053    
Vesting of restricted stock units (in shares)   92,641      
Vesting of restricted stock units 0 $ 1 (1)    
Stock-based compensation 25,527   25,527    
Net loss (124,119)       (124,119)
Other comprehensive loss $ (1,098)     (1,098)  
Ending balance (in shares) at Jun. 30, 2025 145,685,442 145,685,442      
Ending balance at Jun. 30, 2025 $ 1,027,053 $ 1,783 $ 2,820,404 $ 939 $ (1,796,073)