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Segment Information | 3 Months Ended
--- | ---
Mar. 31, 2026
Segment Reporting [Abstract] |
Segment Information | Segment Information The Company has one operating segment with the goal to discover, develop and commercialize therapeutics (“Therapeutics”). There have been no material changes to the Company's segment structure, the basis of segmentation, or the measurement basis for segment profit or loss or segment assets, compared to those disclosed in Note 14, "Segment Information", to the consolidated financial statements in the Company's 2025 Annual Report on Form 10-K. The following table presents selected financial information with respect to the Company’s single operating segment for the three months ended March 31, 2026 and 2025 (in thousands):
| Therapeutics Segment
| Three Months Ended March 31, |  |  |  |
| 2026 |  | 2025 |  |  |  |  |  |
Expenses |  |  |  |  |  |  |  |  |
External research and development expenses - TV programs, including cost sharing | $ | 38,464 |  |  | $ | 41,987 |  |  |  |  |  |  |
Other research and development expenses, including small molecule programs | $ | 23,554 |  |  | $ | 33,971 |  |  |  |  |  |  |
Personnel related research and development expenses | 41,828 |  |  | 40,269 |  |  |  |  |  |  |
Total research and development expenses | 103,846 |  |  | 116,227 |  |  |  |  |  |  |
Personnel related general and administrative expenses | 22,564 |  |  | 18,738 |  |  |  |  |  |  |
Other general and administrative expenses | 10,947 |  |  | 10,615 |  |  |  |  |  |  |
Total general and administrative expenses | 33,511 |  |  | 29,353 |  |  |  |  |  |  |
Segment operating expenses | 137,357 |  |  | 145,580 |  |  |  |  |  |  |
Segment loss from operations | (137,357) |  |  | (145,580) |  |  |  |  |  |  |
Segment interest and other income, net | 8,910 |  |  | 12,610 |  |  |  |  |  |  |
Segment net loss | $ | (128,447) |  |  | $ | (132,970) |  |  |  |  |  |  |
There is no difference between the segment net loss and total consolidated net loss for the three months ended March 31, 2026 and 2025.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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