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Collaboration Agreements - Schedule of Cost Sharing Payments and Reimbursements (Details) - USD ($) $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2026 | Mar. 31, 2025 | Dec. 31, 2025
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Net cost sharing payments (reimbursements) | $ 2,246 | $ 2,988 |
Other accrued costs and current liabilities | 69,776 |  | $ 97,846
Takeda Pharmaceutical Company Limited |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Net cost sharing payments (reimbursements) | (1,617) | (1,663) |
Takeda Pharmaceutical Company Limited | Collaborative Arrangement, PTV:PGRN |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Net cost sharing payments (reimbursements) | (1,617) | (1,511) |
Takeda Pharmaceutical Company Limited | Collaborative Arrangement, ATV:TREM2 |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Net cost sharing payments (reimbursements) | 0 | (152) |
Takeda Pharmaceutical Company Limited | Collaborative Arrangement, PTV:PGRN and ATV:TREM2 |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Receivable | 1,600 |  | 1,600
Biogen | LRRK2 Product |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Net cost sharing payments (reimbursements) | 3,863 | $ 4,651 |
Biogen | Biogen Collaborative Arrangement |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Other accrued costs and current liabilities | $ 3,900 |  | $ 2,800

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