XML 14 R1.htm IDEA: XBRL DOCUMENT v3.26.1
Cover Page - shares
 3 Months Ended
Mar. 31, 2026
May 01, 2026
Cover [Abstract]    
Document Type 10-Q  
Document Quarterly Report true  
Document Period End Date Mar. 31, 2026  
Document Transition Report false  
Entity File Number 001-38311  
Entity Registrant Name Denali Therapeutics Inc.  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 46-3872213  
Entity Address, Address Line One 161 Oyster Point Blvd  
Entity Address, City or Town South San Francisco  
Entity Address, State or Province CA  
Entity Address, Postal Zip Code 94080  
City Area Code 650  
Local Phone Number 866-8547  
Title of 12(b) Security Common Stock, par value $0.01 per share  
Trading Symbol DNLI  
Security Exchange Name NASDAQ  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Large Accelerated Filer  
Entity Small Business false  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   158,709,737
Document Fiscal Year Focus 2026  
Document Fiscal Period Focus Q1  
Amendment Flag false  
Entity Central Index Key 0001714899  
Current Fiscal Year End Date --12-31