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Segment Information (Details)
$ in Thousands
 3 Months Ended
Mar. 31, 2026
USD ($)
segment
Mar. 31, 2025
USD ($)
Segment Reporting Information [Line Items]    
Number of operating segments | segment 1  
Number of reportable segments | segment 1  
Expenses    
Total research and development expenses $ 103,846 $ 116,227
Total general and administrative expenses 33,511 29,353
Total operating expenses 137,357 145,580
Loss from operations (137,357) (145,580)
Segment interest and other income, net 8,910 12,610
Therapeutics Segment    
Expenses    
External research and development expense 38,464 41,987
Other research and development expenses, including small molecule programs 23,554 33,971
Personnel related research and development expenses 41,828 40,269
Total research and development expenses 103,846 116,227
Personnel related general and administrative expenses 22,564 18,738
Other general and administrative expenses 10,947 10,615
Total general and administrative expenses 33,511 29,353
Total operating expenses 137,357 145,580
Loss from operations (137,357) (145,580)
Segment interest and other income, net 8,910 12,610
Loss before income taxes $ (128,447) $ (132,970)