Royalty Funding Arrangement, Additional Payment

No definition available.

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Namespace Prefix:	dnli_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

Royalty Funding Arrangement, Authorized Funding

+ References

No definition available.

+ Details

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Namespace Prefix:	dnli_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Royalty Funding Arrangement, Initial Investment Proceeds Multiple, Maximum

+ References

No definition available.

+ Details

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Period Type:	instant

- Definition

Royalty Funding Arrangement, Initial Investment Proceeds Multiple, Minimum

+ References

No definition available.

+ Details

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- Definition

Royalty Funding Arrangement, Interest Rate, Effective Percentage

+ References

No definition available.

+ Details

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Period Type:	instant

- Definition

Royalty Funding Arrangement, Noncash Interest Expense

+ References

No definition available.

+ Details

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Data Type:	xbrli:monetaryItemType
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Period Type:	duration

- Definition

Royalty Funding Arrangement, Royalty Rate

+ References

No definition available.

+ Details

Name:	dnli_RoyaltyFundingArrangementRoyaltyRate
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Data Type:	dtr-types:percentItemType
Balance Type:	na
Period Type:	instant

- Definition

Royalty Funding Arrangement, Transaction Costs

+ References

No definition available.

+ Details

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Namespace Prefix:	dnli_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

+ Details

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Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

- Definition

The amount of cash paid for royalties during the current period.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Section 45
-Paragraph 25
-Subparagraph (g)
-SubTopic 10
-Topic 230
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482740/230-10-45-25

+ Details

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

- Definition

The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 3
-Subparagraph (SX 210.6-03(i)(1))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479886/946-10-S99-3

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482740/230-10-45-14

+ Details

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Details

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Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_DebtInstrumentAxis=dnli_RoyaltyAgreementMember
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Liability Related to the Revenue Participation Right (Details) - USD ($)	1 Months Ended	3 Months Ended	6 Months Ended
	Mar. 31, 2026	Jun. 30, 2026	Jun. 30, 2026	Jun. 30, 2025	Dec. 31, 2025
Other Commitments [Line Items]
Non-cash interest expense related to revenue participation right liability			$ 5,941,000	$ 0
Royalty Pharma \| Royalty Agreement
Other Commitments [Line Items]
Authorized funding					$ 275,000,000.0
Royalty rate					9.25%
Proceeds received	$ 200,000,000.0
Additional payment					$ 75,000,000.0
Initial investment proceeds multiple, maximum					3.0
Initial investment proceeds multiple, minimum					2.5
Transaction costs	$ 400,000
Annual interest rate		12.00%	12.00%
Non-cash interest expense related to revenue participation right liability		$ 5,900,000
Payments for royalties		$ 0	$ 0