<SEC-DOCUMENT>0001724311-26-000004.txt : 20260106
<SEC-HEADER>0001724311-26-000004.hdr.sgml : 20260106
<ACCEPTANCE-DATETIME>20260106202534
ACCESSION NUMBER:		0001724311-26-000004
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20260106
DATE AS OF CHANGE:		20260106

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Denali Therapeutics Inc.
		CENTRAL INDEX KEY:			0001714899
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				463872213
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38311
		FILM NUMBER:		26513664

	BUSINESS ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(650) 866-8547

	MAIL ADDRESS:	
		STREET 1:		161 OYSTER POINT BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Schuth Alexander O.
		CENTRAL INDEX KEY:			0001724311
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O DENALI THERAPEUTICS INC.
		STREET 2:		151 OYSTER POINT BLVD., 2ND FLOOR
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <filer>
        <filerCredentials>
          <cik>0001724311</cik>
          <ccc>XXXXXXXX</ccc>
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      <liveTestFlag>LIVE</liveTestFlag>



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    <issuerInfo>
      <issuerCik>0001714899</issuerCik>
      <issuerName>Denali Therapeutics Inc.</issuerName>
      <secFileNumber>001-38311</secFileNumber>
      <issuerAddress>
        <com:street1>161 Oyster Point Blvd,</com:street1>
        <com:city>South San Francisco</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94080</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>6508668547</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Schuth Alexander O.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>38th Fl.</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>17218</noOfUnitsSold>
      <aggregateMarketValue>284097</aggregateMarketValue>
      <noOfUnitsOutstanding>156182177</noOfUnitsOutstanding>
      <approxSaleDate>01/06/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/03/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse - See Remarks</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Denali Therapeutics Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>17218</amountOfSecuritiesAcquired>
      <paymentDate>01/03/2026</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Shares sold to cover tax obligation from settlement of vested Restricted Stock Units.</remarks>
    <noticeSignature>
      <noticeDate>01/06/2026</noticeDate>
      <signature>/s/ Tyler Nielsen, by power of attorney</signature>
    </noticeSignature>
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