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v3.25.3

SEGMENT INFORMATION - Schedule of reconciliation to the consolidated net loss (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Revenue: |  |  |  |  |  |  |  |  |
Screening revenue |  | $ 36,194 |  |  | $ 28,652 |  |  | $ 103,575 | $ 87,343
Costs and operating expenses: |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 14,139 |  |  | 17,449 |  |  | 44,518 | 72,502
Goodwill and intangible assets impairment |  | 0 |  |  | 0 |  |  | 28,000 | 1,420,936
Total costs and operating expenses |  | 161,485 |  |  | 212,159 |  |  | 541,327 | 2,139,563
Loss from operations |  | (125,291) |  |  | (183,507) |  |  | (437,752) | (2,052,220)
Other income (expense): |  |  |  |  |  |  |  |  |
Interest income |  | 6,107 |  |  | 11,661 |  |  | 20,695 | 17,367
Other income (expense), net |  | 466 |  |  | (561) |  |  | (929) | (514)
Benefit from income taxes |  | 29,741 |  |  | 46,719 |  |  | 108,811 | 105,428
Net loss |  | (88,977) | $ (113,985) | $ (106,213) | (125,688) | $ (1,585,337) | $ (218,914) | (309,175) | (1,929,939)
Depreciation |  |  |  |  |  |  |  | 13,686 | 14,865
Reportable Segment |  |  |  |  |  |  |  |  |
Revenue: |  |  |  |  |  |  |  |  |
Screening revenue |  | 36,194 |  |  | 28,652 |  |  | 103,575 | 87,343
Costs and operating expenses: |  |  |  |  |  |  |  |  |
Compensation |  | 53,375 |  |  | 84,733 |  |  | 173,537 | 257,578
Depreciation and intangible assets amortization expense |  | 37,646 |  |  | 38,630 |  |  | 112,577 | 114,808
Stock-based compensation |  | 13,868 |  |  | 16,871 |  |  | 43,068 | 70,980
Professional services |  | 8,831 |  |  | 11,298 |  |  | 27,353 | 52,459
Cloud computing and information technology |  | 6,416 |  |  | 7,517 |  |  | 19,537 | 23,619
Clinical studies |  | 7,835 |  |  | 8,048 |  |  | 20,020 | 39,280
Laboratory supplies and research collaborations |  | 3,242 |  |  | 8,556 |  |  | 10,421 | 37,631
Facilities |  | 5,517 |  |  | 6,185 |  |  | 16,510 | 21,344
Other segment expenses |  | 8,301 |  |  | 12,909 |  |  | 35,709 | 51,948
Goodwill and intangible assets impairment |  | 0 |  |  | 0 |  |  | 28,000 | 1,420,936
Total costs and operating expenses |  | 161,485 |  |  | 212,159 |  |  | 541,327 | 2,139,563
Loss from operations |  | (125,291) |  |  | (183,507) |  |  | (437,752) | (2,052,220)
Other income (expense): |  |  |  |  |  |  |  |  |
Interest income |  | 6,107 |  |  | 11,661 |  |  | 20,695 | 17,367
Other income (expense), net |  | 466 |  |  | (561) |  |  | (929) | (514)
Benefit from income taxes |  | 29,741 |  |  | 46,719 |  |  | 108,811 | 105,428
Net loss |  | (88,977) |  |  | (125,688) |  |  | (309,175) | (1,929,939)
Depreciation |  | 1,300 |  |  | 600 |  |  | 4,900 | 3,800
Screening revenue |  |  |  |  |  |  |  |  |
Revenue: |  |  |  |  |  |  |  |  |
Screening revenue | [1] | 32,807 |  |  | 25,374 |  |  | 96,319 | 77,076
Costs and operating expenses: |  |  |  |  |  |  |  |  |
Cost of revenue | [2] | 15,910 |  |  | 15,970 |  |  | 52,379 | 45,481
Screening revenue | Reportable Segment |  |  |  |  |  |  |  |  |
Revenue: |  |  |  |  |  |  |  |  |
Screening revenue |  | 32,807 |  |  | 25,374 |  |  | 96,319 | 77,076
Costs and operating expenses: |  |  |  |  |  |  |  |  |
Cost of revenue |  | 15,910 |  |  | 15,970 |  |  | 52,379 | 45,481
Development services revenue |  |  |  |  |  |  |  |  |
Revenue: |  |  |  |  |  |  |  |  |
Screening revenue |  | 3,387 |  |  | 3,278 |  |  | 7,256 | 10,267
Costs and operating expenses: |  |  |  |  |  |  |  |  |
Cost of revenue | [3] | 544 |  |  | 1,442 |  |  | 2,216 | 3,499
Development services revenue | Reportable Segment |  |  |  |  |  |  |  |  |
Revenue: |  |  |  |  |  |  |  |  |
Screening revenue |  | 3,387 |  |  | 3,278 |  |  | 7,256 | 10,267
Costs and operating expenses: |  |  |  |  |  |  |  |  |
Cost of revenue |  | $ 544 |  |  | $ 1,442 |  |  | $ 2,216 | $ 3,499
[1] | ncludes related party screening revenue of $50 and $179 for the three and nine months ended September 30, 2025 and $129 and $366 for the three and nine months ended September 30, 2024, respectively.
[2] | ncludes related party cost of screening revenue of $1,237 and $3,924 for the three and nine months ended September 30, 2025 and $3,658 and $9,784 for the three and nine months ended September 30, 2024, respectively.
[3] | Includes related party cost of development services revenue of $78 and $260 for the three and nine months ended September 30, 2025 and $143 and $259 for the three and nine months ended September 30, 2024, respectively.

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