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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOW - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Cash flows from operating activities |  |  |
Net loss |  | $ (309,175) | $ (1,929,939)
Adjustments to reconcile net loss to net cash used by operating activities: |  |  |
Amortization of intangibles assets |  | 103,750 | 103,750
Depreciation |  | 13,686 | 14,865
Stock-based compensation expense |  | 44,518 | 72,502
Cash payment for equity awards |  | 0 | (53,807)
Deferred income taxes |  | (108,811) | (104,990)
Amortization of discount on marketable securities |  | (16,606) | 0
Goodwill and intangible assets impairment |  | 28,000 | 1,420,936
Credit loss expense |  | 518 | 0
Other |  | 1,370 | 949
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | [1] | 3,512 | 1,731
Supplies | [2] | 452 | 482
Operating lease right-of-use assets and liabilities, net |  | 761 | 1,545
Prepaid expenses and other assets | [3] | 3,346 | (1,278)
Accounts payable | [4] | (1,437) | (12,203)
Accrued and other liabilities | [5] | 894 | 1,791
Net cash used in operating activities |  | (235,222) | (483,666)
Cash flows from investing activities |  |  |
Purchases of property and equipment |  | (815) | (4,905)
Purchases of marketable securities |  | (741,932) | 0
Proceeds from maturities of marketable securities |  | 894,400 | 0
Net cash provided by (used in) investing activities |  | 151,653 | (4,905)
Cash flows from financing activities |  |  |
Cash funding received from Illumina |  | 0 | 1,244,300
Net cash provided by financing activities |  | 0 | 1,244,300
Effect of exchange rate changes on cash, cash equivalents, and restricted cash |  | (148) | 228
Net (decrease) increase in cash, cash equivalents, and restricted cash |  | (83,717) | 755,957
Cash, cash equivalents and restricted cash — beginning of period |  | 217,583 | 101,512
Cash, cash equivalents and restricted cash — end of period |  | 133,866 | 857,469
Represented by: |  |  |
Cash and cash equivalents |  | 126,892 | 853,551
Restricted cash |  | 6,974 | 3,918
Total |  | 133,866 | 857,469
Supplemental cash flow information: |  |  |
Property and equipment included in accounts payable and accrued liabilities |  | (70) | (231)
Operating cash flows paid for operating leases, net |  | $ (12,673) | $ (14,773)
[1] | Includes changes in related party accounts receivable of $31 and $32, respectively.
[2] | Includes changes in related party supplies of $2,155 and $1,329, respectively.
[3] | Includes changes in related party prepaid and other current assets of $15 and $(24), respectively.
[4] | Includes changes in related party accounts payable of $54 and $(824), respectively.
[5] | Includes changes in related party accrued liabilities of $(10) and $2,726, respectively.

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