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Income Taxes - Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | --- | ---
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ 38,895 | $ 39,236 |
Stock-based compensation | 3,096 | 2,427 |
Depreciation and amortization | 0 | 245 |
Non-deductible accrued expenses and reserves | 2,916 | 683 |
Research and development credits | 6,724 | 4,629 |
Gross deferred tax assets | 51,631 | 47,220 |
Deferred tax liabilities: |  |  |
Acquired intangible assets | (1,298) | (1,856) |
Depreciation and amortization | (894) | 0 |
Net deferred tax assets prior to valuation allowance | 49,439 | 45,364 |
Valuation allowance | (49,439) | (45,364) | $ (64,300)
Net deferred tax assets | $ 0 | $ 0 |

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