Exhibit 99.1

For Immediate Release

Contacts:

Jim Brill

SVP, Finance and Chief Financial Officer

(818) 878-7900

On Assignment Reports Third Quarter 2008 Results

Record Quarterly Revenues of $161.9 Million and Net Income of $6.9 Million

CALABASAS, Calif., October 29, 2008 — On Assignment, Inc. (NASDAQ: ASGN), a diversified professional staffing firm providing flexible and permanent staffing solutions in specialty skills including Laboratory/Scientific, Healthcare/Nursing/Physicians, Medical Financial, Information Technology and Engineering, today reported results for the quarter ended September 30, 2008.

Third Quarter 2008 Financial Comparisons and Analysis:

· Revenues for the third quarter of 2008 were $161.9 million and above the high-end of the Company’s previously announced estimate of $156.5 to $160.0 million. Revenues were up 8.9% from the third quarter of 2007 and grew at a faster rate than the 8.5% in the 2^nd quarter of 2008.

· Gross margin was 32.6%, up from 32.0% in the third quarter of 2007.

· Net income was $6.9 million, or $0.19 per share, up 113% from $3.3 million, or $0.09 per share, in the third quarter of 2007 and above the high end of the Company’s previously-announced estimate of $0.14 to $0.17 per share.  Net income for the quarter included a non-cash gain of $503,000, or $0.01 per share, on the Company’s $73 million interest rate swap.  This mark-to-market adjustment was not included in the Company’s estimates and compares with a loss of $915,000, or $0.01 per share, in the same period last year.

· Adjusted EBITDA (a non-GAAP measurement defined below) for the quarter was $18.8 million, up 17.1% from $16.0 million for the same period in 2007.

· Interest expense, net of interest income, for the quarter was of $2.2 million compared with $2.6 million in the third quarter of 2007.

For the third quarter of 2008, the Healthcare segment revenues, which include Nurse Travel and Allied Healthcare lines of business, were $48.0 million, up 7.8% from $44.5 million in the same period of 2007.  Nurse Travel revenues of $33.4 million were up 8.5% from $30.8 million in the same period of 2007. Allied Healthcare revenues of $14.6 million were up 6.2% from $13.7 million in the same period of 2007. The Physician segment had revenues of $23.6 million, an increase of 23.4% over $19.1 million in the same period of 2007, and the IT and Engineering segment revenues were $56.4 million, an increase of 11.5% over $50.6 million in the same period of 2007. The Life Sciences segment revenues were $33.9 million, down 1.4% from $34.4 million in the same period of 2007.

Peter Dameris, President and Chief Executive Officer of On Assignment, Inc., said, “In spite of the loss of approximately 800,000 jobs this year in the U.S. labor markets and an increasingly more difficult U.S. economy, our business model, once again, permitted us to perform well and gain market share in the end markets we serve.” Dameris concluded, “During these uncertain economic times, our focus will remain on improving the diversity of our customer and skill mix, maintaining our gross margins, leveraging our back office infrastructure and generating cash. Based on the performance we have reported in 2008, we believe

that we are well positioned to meet our goals of maintaining gross margins, generating cash and acquiring market share.”

Jim Brill, Senior Vice President and Chief Financial Officer of On Assignment, Inc. stated, “Our third quarter gross margin was 32.6%, up 60 basis points over last year’s third quarter. In the third quarter of 2008, gross margin in Life Sciences was 34.2%, Healthcare gross margin was 25.6%, our Physician segment gross margin was 31.6% and the IT and Engineering segment gross margin was 38.1%. Bill/pay spreads in each of our segments expanded in the third quarter versus the same period of 2007.” Brill continued, “Our operating and Adjusted EBITDA margins expanded to 8.4% and 11.6%, respectively and once again, we increased our cash and cash equivalents to $48.7 million from $40.1 million at the end of the second quarter. Amortization of intangibles was $2.4 million, depreciation was $1.2 million and equity-based compensation expense was $1.6 million.”

Fourth Quarter 2008 Financial Estimates:

Based on revenues in the first three weeks of the fourth quarter of 2008 and assuming normal seasonal patterns and no deterioration in the staffing markets that On Assignment serves, the Company provided the following financial estimates for the quarter ending December 31, 2008:

· Revenues of $152.0 to $156.5 million

· Gross margin of 31.85% to 32.10%

· SG&A of $38.7 to $39.3 million, including depreciation of approximately $1.4 million, amortization of intangibles of approximately $2.4 million and approximately $1.5 million in equity-based compensation expense

· Adjusted EBITDA of $14.4 to $16.8 million

· Net income of $4.0 to $5.4 million

· Earnings per share of $0.11 to $0.15

The financial estimates set forth above do not include any potential impact from the mark-to-market of the Company’s $73 million interest rate swap in the fourth quarter.

On Assignment will hold its quarterly conference call to discuss its third quarter 2008 financial results tomorrow morning, Thursday October 30, 2008 at 6:00 a.m. Pacific Time.  Interested parties are invited to listen to the conference call by dialing (800) 374-0509 or (706) 679-6365 ten minutes before the call. The conference code is 67522595. A replay of the conference call can be accessed from approximately 9:00 a.m. Pacific Time Thursday October 30, 2008 through Thursday November 6, 2008 by dialing (800) 642-1687 or (706) 645-9291 with the access code 67522595.

This call is being webcast by Thomson/CCBN and can be accessed via On Assignment’s web site at www.onassignment.com.  Individual investors can also listen at Thomson/CCBN’s site at www.fulldisclosure.com or by visiting any of the investor sites in Thomson/CCBN’s Individual Investor Network.  Institutional investors can access the call via Thomson/CCBN’s password-protected event management site, StreetEvents at www.streetevents.com.

About On Assignment

On Assignment, Inc. is a diversified professional staffing firm providing flexible and permanent staffing solutions in specialty skills including Laboratory/Scientific, Healthcare/Nursing/Physicians, Medical Financial, Information Technology and Engineering. The corporate headquarters are located in Calabasas, California.  On Assignment, Inc. was founded in 1985 as On Assignment/Lab Support and went public in 1992.  The Company’s branch network encompasses approximately 80 branch offices across the United States, United Kingdom, Netherlands, Canada, Ireland and Belgium and the Company also provides physicians in Australia and New Zealand.

Reasons for Presentation of Non-GAAP Financial Measures

Statements made in this release and the Supplemental Financial Information accompanying this release include non-GAAP financial measures.  Such information is provided as additional information, not as an alternative to our consolidated financial statements presented in accordance with GAAP, and is intended to enhance an overall understanding of our current financial performance.  The Supplemental Financial Information sets forth financial measures reviewed by our management to evaluate our operating

performance.  Such measures also are used to determine a portion of the compensation for some of our executives and employees.  We believe the non-GAAP financial measures provide useful information to management, investors and prospective investors by excluding certain charges and other amounts that we believe are not indicative of our core operating results.  These non-GAAP measures are included to provide management, our investors and prospective investors with an alternative method for assessing our operating results in a manner that is focused on the performance of our ongoing operations and to provide a more consistent basis for comparison between quarters.  One of the non-GAAP financial measures presented is EBITDA (earnings before interest, taxes, depreciation, amortization of identifiable intangible assets), another term is Adjusted EBITDA (EBITDA plus equity-based compensation expense), which terms might not be calculated in the same manner as, and thus might not be comparable to, similarly titled measures reported by other companies.  The financial statement tables that accompany this press release include reconciliation of each non-GAAP financial measure to the most directly comparable GAAP financial measure.

Safe Harbor

Certain statements made in this news release are “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and involve a high degree of risk and uncertainty.  Forward-looking statements include statements regarding the Company’s anticipated financial and operating performance in 2008.  All statements in this release, other than those setting forth strictly historical information, are forward-looking statements.  Forward-looking statements are not guarantees of future performance, and actual results might differ materially.  In particular, the Company makes no assurances that the estimates of revenues, gross margins, SG&A, Adjusted EBITDA, net income or earnings per share set forth above will be achieved. Factors that could cause or contribute to such differences include actual demand for our services, our ability to attract, train and retain qualified staffing consultants, our ability to remain competitive in obtaining and retaining temporary staffing clients, the availability of qualified temporary nurses and other qualified temporary professionals, management of our growth, continued performance of our enterprise-wide information systems, and other risks detailed from time to time in our reports filed with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the year ended December 31, 2007, as filed with the SEC on March 17, 2008 and our Quarterly Reports on Form 10-Q for the quarters ended March 31, 2008, as filed with the SEC on May 12, 2008 and June 30, 2008, as filed with the SEC on August 8, 2008. We specifically disclaim any intention or duty to update any forward-looking statements contained in this news release.

SUMMARY CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share amounts)

(unaudited)

		Quarter Ended									Nine Months Ended
		September 30,						June 30,			September 30,
		2008			2007			2008			2008			2007
Revenues		$	161,947		$	148,657		$	156,082		$	470,442		$	415,140
Cost of Services		109,138			101,130			105,418			319,541			283,912
Gross Profit		52,809			47,527			50,664			150,901			131,228
Selling, General and Administrative Expenses		39,190			38,326			38,826			117,713			111,579
Operating Income		13,619			9,201			11,838			33,188			19,649
Interest Expense		(2,366		)	(2,940		)	(2,323		)	(7,351		)	(8,064		)
Interest Income		158			344			158			589			982
Other Income(Expense)		503			(915		)	1,071			352			(484		)
Income before Income Taxes		11,914			5,690			10,744			26,778			12,083
Income Tax Provision		4,977			2,435			4,652			11,346			4,979
Net Income		$	6,937		$	3,255		$	6,092		$	15,432		$	7,104
Diluted Earnings Per Share		$	0.19		$	0.09		$	0.17		$	0.43		$	0.20
Weighted Average Common and Common Equivalent Shares Outstanding—Diluted		36,071			35,886			35,838			35,795			35,744

SUPPLEMENTAL SEGMENT FINANCIAL INFORMATION

(In thousands)

(unaudited)

		Quarter Ended									Nine Months Ended
		September 30,						June 30,			September 30,
		2008			2007			2008			2008			2007
Revenues:
Life Sciences		$	33,948		$	34,431		$	32,122		$	98,653		$	99,488
Healthcare Staffing		47,999			44,524			45,844			138,368			130,825
Physician Staffing		23,612			19,138			21,814			66,005			55,237
IT and Engineering		56,388			50,564			56,302			167,416			129,590
Consolidated Revenues		$	161,947		$	148,657		$	156,082		$	470,442		$	415,140
Gross Profit:
Life Sciences		$	11,609		$	11,585		$	10,602		$	32,926		$	33,361
Healthcare Staffing		12,265			11,295			12,092			35,121			32,882
Physician Staffing		7,455			5,564			6,702			19,967			16,511
IT and Engineering		21,480			19,083			21,268			62,887			48,474
Consolidated Gross Profit		$	52,809		$	47,527		$	50,664		$	150,901		$	131,228

SELECTED CASH FLOW INFORMATION

(In thousands)

(unaudited)

		Quarter Ended									Nine Months Ended
		September 30,						June 30,			September 30,
		2008			2007			2008			2008			2007
Cash provided by Operations		$	10,281		$	8,568		$	8,604		$	25,726		$	22,337
Capital Expenditures		1,348			1,685			2,465			6,344			4,339

SELECTED CONSOLIDATED BALANCE SHEET DATA

(In thousands)

(unaudited)

		As of
		September 30,						June 30,
		2008			2007			2008
Cash and Cash Equivalents		$	48,737		$	37,042		$	40,051
Accounts Receivable, net		87,567			81,783			84,654
Intangible Assets, net		227,807			231,668			230,175
Total Assets		402,423			383,203			390,946
Current Portion of Long-Term Debt		1,040			1,450			693
Current Liabilities		48,156			43,389			46,275
Long-Term Debt		134,872			142,463			135,219
Other Long-Term Liabilities		5,709			5,891			3,707
Stockholders’ Equity		213,686			191,460			205,745

RECONCILIATION OF GAAP NET INCOME AND EARNINGS PER SHARE TO NON-GAAP EBITDA AND EBITDA PER SHARE

(In thousands, except per share amounts)

(unaudited)

		Quarter Ended
		September 30, 2008						September 30, 2007						June 30, 2008
Net Income		$	6,937		$	0.19		$	3,255		$	0.09		$	6,092		$	0.17
Other Expense (Income)		(503		)	(0.01		)	915			0.03			(1,071		)	(0.03		)
Interest Expense, net		2,208			0.06			2,596			0.07			2,165			0.06
Income Tax Provision		4,977			0.14			2,435			0.07			4,652			0.13
Depreciation		1,202			0.03			1,624			0.05			1,216			0.03
Amortization of Intangibles		2,368			0.07			3,745			0.10			2,372			0.07
		17,189			0.48			14,570			0.41			15,426			0.43
Equity-based Compensation		1,596			0.04			1,472			0.04			1,560			0.04
Adjusted EBITDA		$	18,785		$	0.52		$	16,042		$	0.45		$	16,986		$	0.47
Weighted Average Common and Common Equivalent Shares Outstanding		36,071						35,886						35,838

		Nine Months Ended
		September 30, 2008						September 30, 2007
Net Income		$	15,432		$	0.43		$	7,104		$	0.20
Other Expense (Income)		(352		)	(0.01		)	484			0.01
Interest Expense, net		6,762			0.19			7,082			0.20
Income Tax Provision		11,346			0.32			4,979			0.14
Depreciation		3,774			0.10			4,516			0.12
Amortization of Intangibles		7,068			0.20			11,688			0.33
EBITDA		44,030			1.23			35,853			1.00
Equity-based Compensation		4,741			0.13			4,809			0.14
Adjusted EBITDA		$	48,771		$	1.36		$	40,662		$	1.14
Weighted Average Common and Common Equivalent Shares Outstanding		35,795						35,744

RECONCILIATION OF ESTIMATED GAAP NET INCOME TO ESTIMATED NON-GAAP EBITDA AND ADJUSTED EBITDA

(In thousands)

(unaudited)

		Estimated Range of Results Quarter Ending December 31, 2008
Net Income(1)		$	4,000		$	5,400
Interest Expense		2,200			2,200
Income Tax Provision		2,900			3,900
Depreciation and Amortization		3,800			3,800
EBITDA		12,900			15,300
Equity-based Compensation		1,500			1,500
Adjusted EBITDA		$	14,400		$	16,800

	(1)	The financial estimates set forth above do not include any potential impact from the mark-to-market of the
		Company’s $73 million interest rate swap in the fourth quarter.

SUPPLEMENTAL FINANCIAL INFORMATION – REVENUES AND GROSS MARGINS
(Unaudited)

(Dollars in thousands)

					Healthcare
		Life Sciences			Allied Healthcare			Nurse Travel			Total Healthcare			Physician Staffing			IT and Engineering			Consolidated
Revenues:
Q3 2008		$	33,948		$	14,552		$	33,447		$	47,999		$	23,612		$	56,388		$	161,947
Q2 2008		$	32,122		$	14,604		$	31,240		$	45,844		$	21,814		$	56,302		$	156,082
% Sequential Change		5.7		%	-0.4		%	7.1		%	4.7		%	8.2		%	0.2		%	3.8		%
Q3 2007		$	34,431		$	13,698		$	30,826		$	44,524		$	19,138		$	50,564		$	148,657
% Year-over-Year Change		-1.4		%	6.2		%	8.5		%	7.8		%	23.4		%	11.5		%	8.9		%
Gross Margins:
Q3 2008		34.2		%	31.8		%	22.8		%	25.6		%	31.6		%	38.1		%	32.6		%
Q2 2008		33.0		%	32.5		%	23.5		%	26.4		%	30.7		%	37.8		%	32.5		%
Q3 2007		33.6		%	32.3		%	22.3		%	25.4		%	29.1		%	37.7		%	32.0		%

SUPPLEMENTAL FINANCIAL INFORMATION – KEY METRICS

(Unaudited)

		Quarter Ended
		September 30, 2008			June 30, 2008
Percentage of Revenues:
Top Ten Clients		6.9		%	7.0		%
Direct Hire/Conversion		2.0		%	1.8		%
Bill Rate Increase:
% Sequential Growth		0.2		%	1.7		%
% Year-over-Year Growth		8.0		%	11.3		%
Bill/Pay Spread:
% Sequential Change		1.0		%	2.0		%
% Year-over-Year Growth		7.9		%	11.1		%
Average Headcount:
Contract Professionals (CP)		5,115			4,981
Staffing Consultants (SC)		742			784
Productivity:
Gross Profit per SC		$	71,000		$	65,000