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Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Revenue |  |  |
Total revenue | $ 154,344 | $ 98,382 | $ 85,071
Operating expenses |  |  |
Cost of revenue | 49,301 | 22,530 | 22,274
Research and development | 142,343 | 116,072 | 70,705
Sales and marketing | 95,465 | 61,358 | 38,453
General and administrative | 74,502 | 49,536 | 30,332
Amortization of intangible assets | 1,699 | 1,703 | 1,698
Total operating expenses | 363,310 | 251,199 | 163,462
Loss from operations | (208,966) | (152,817) | (78,391)
Interest and other income, net | 1,668 | 6,590 | 9,785
Net loss | (207,298) | (146,227) | (68,606)
Add: Net loss attributable to noncontrolling interest | 19 |  |
Net loss attributable to Adaptive Biotechnologies Corporation | (207,279) | (146,227) | (68,606)
Fair value adjustment to Series E-1 convertible preferred stock options |  |  | (964)
Net loss attributable to Adaptive Biotechnologies Corporation common shareholders | $ (207,279) | $ (146,227) | $ (69,570)
Net loss per share attributable to Adaptive Biotechnologies Corporation common shareholders, basic and diluted | $ (1.48) | $ (1.11) | $ (1.01)
Weighted-average shares used in computing net loss per share attributable to Adaptive Biotechnologies Corporation common shareholders, basic and diluted | 140,354,915 | 131,216,468 | 69,165,315
Sequencing Revenue |  |  |
Revenue |  |  |
Total revenue | $ 78,896 | $ 41,439 | $ 43,519
Development Revenue |  |  |
Revenue |  |  |
Total revenue | $ 75,448 | $ 56,943 | $ 41,552

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