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v3.22.2.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Operating activities |  |
Net loss | $ (160,199) | $ (145,941)
Adjustments to reconcile net loss to net cash used in operating activities |  |
Depreciation expense | 14,364 | 7,834
Noncash lease expense | 5,423 | 5,259
Share-based compensation expense | 41,183 | 31,376
Intangible assets amortization | 1,270 | 1,270
Investment amortization | 1,825 | 5,956
Research and development inventory reserve | 2,638 |
Interest expense | 653 |
Other | (20) | (9)
Changes in operating assets and liabilities |  |
Accounts receivable, net | (9,139) | (7,075)
Inventory | (2,212) | (4,168)
Prepaid expenses and other current assets | 601 | (2,239)
Accounts payable and accrued liabilities | (3,419) | 5,518
Operating lease right-of-use assets and liabilities | (3,041) | 9,935
Deferred revenue | (44,018) | (46,345)
Other | 165 | (272)
Net cash used in operating activities | (153,926) | (138,901)
Investing activities |  |
Purchases of property and equipment | (13,807) | (52,501)
Purchases of marketable securities | (113,744) | (238,001)
Proceeds from maturities of marketable securities | 228,000 | 404,500
Net cash provided by investing activities | 100,449 | 113,998
Financing activities |  |
Proceeds from exercise of stock options | 7,568 | 23,439
Proceeds from revenue interest purchase agreement, net of issuance costs | 124,691 |
Proceeds from initial capital contributions for Digital Biotechnologies, Inc. |  | 429
Net cash provided by financing activities | 132,259 | 23,868
Net increase (decrease) in cash, cash equivalents and restricted cash | 78,782 | (1,035)
Cash, cash equivalents and restricted cash at beginning of year | 141,203 | 125,574
Cash, cash equivalents and restricted cash at end of period | 219,985 | 124,539
Noncash investing and financing activities |  |
Purchases of equipment included in accounts payable and accrued liabilities | 2,619 | $ 8,133
Revenue interest purchase agreement issuance costs included in accounts payable and accrued liabilities | $ 316 |

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