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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Provision for Income Taxes

The components of loss before provision for income taxes for the periods presented are as follows (in thousands):

		Year Ended December 31,
		2022				2021				2020
Domestic		$	(200,427	)		$	(207,314	)		$	(146,227	)
Foreign			59				16				—
Total loss before provision for income taxes		$	(200,368	)		$	(207,298	)		$	(146,227	)

Schedule of Components of Deferred Tax Assets and Liabilities

The significant components of our deferred tax assets and liabilities as of the dates presented are as follows (in thousands):

		December 31,
		2022				2021
Deferred tax assets
Net operating losses		$	210,609			$	200,363
Tax credit carryforward			36,848				31,200
Nonqualifying stock options			23,885				18,072
Operating lease liabilities			27,199				30,401
Deferred revenue			26,170				42,481
Capitalized research and development			40,957				—
Other			5,859				4,345
Total deferred tax assets			371,527				326,862
Less: Valuation allowance			(346,578	)			(297,020	)
Deferred tax assets, net of valuation allowance			24,949				29,842
Deferred tax liabilities
Tangible and intangible assets			(4,897	)			(7,310	)
Right-of-use assets			(20,052	)			(22,532	)
Net deferred taxes		$	—			$	—

Schedule of Reconciliation of Effective Tax Rate of Provision for Income Taxes Differs from Federal Statutory Rate

The effective tax rate of our provision for income taxes differs from the federal statutory rate for the periods presented as follows:

		Year Ended December 31,
		2022		2021		2020
Statutory rate		21.0%		21.0%		21.0%
State tax, net of federal tax benefit		3.8		8.3		13.8
Share-based compensation		(2.0)		14.1		25.2
Permanent items		(0.2)		(0.1)		(0.1)
Credits		3.0		4.7		5.7
Other		(1.2)		(0.3)		0.5
Change in valuation allowance		(24.4)		(47.7)		(66.1)
Total		0.0%		0.0%		0.0%

Schedule of Change in Unrecognized Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized tax benefits for the dates presented are as follows (in thousands):

Balance at December 31, 2019		$	2,052
Additions in 2020			1,437
Balance at December 31, 2020			3,489
Additions in 2021			3,426
Balance at December 31, 2021			6,915
Additions in 2022			1,202
Balance at December 31, 2022		$	8,117

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months.

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