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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Operating activities    
Net loss $ (57,700) $ (62,796)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation expense 5,004 4,637
Noncash lease expense 1,805 1,792
Share-based compensation expense 14,671 12,861
Intangible assets amortization 419 419
Investment amortization (1,609) 862
Inventory reserve 1,080  
Noncash interest expense 1,648  
Other 5 (20)
Changes in operating assets and liabilities    
Accounts receivable, net 9,085 (5,109)
Inventory (6,607) (1,739)
Prepaid expenses and other current assets (352) 962
Accounts payable and accrued liabilities (15,878) (7,545)
Operating lease right-of-use assets and liabilities (2,223) 2,035
Deferred revenue (8,486) (10,812)
Other (14)  
Net cash used in operating activities (59,152) (64,453)
Investing activities    
Purchases of property and equipment (2,924) (3,077)
Purchases of marketable securities (89,097) (60,235)
Proceeds from maturities of marketable securities 155,000 101,000
Net cash provided by investing activities 62,979 37,688
Financing activities    
Proceeds from exercise of stock options 672 2,749
Net cash provided by financing activities 672 2,749
Net increase (decrease) in cash, cash equivalents and restricted cash 4,499 (24,016)
Cash, cash equivalents and restricted cash at beginning of year 92,428 141,203
Cash, cash equivalents and restricted cash at end of period 96,927 117,187
Noncash investing activities    
Purchases of equipment included in accounts payable and accrued liabilities 1,651 $ 2,952
Supplemental disclosure of cash flow information    
Cash paid for interest $ 2,760