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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Income Tax Disclosure [Abstract] |
Schedule of Components of Loss Before Provision for Income Taxes | The components of loss before provision for income taxes for the periods presented were as follows (in thousands):
|  | Year Ended December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
Domestic |  | $ | (225,335 | ) |  | $ | (200,427 | ) |  | $ | (207,314 | )
Foreign |  |  | 31 |  |  |  | 59 |  |  |  | 16 |
Total loss before provision for income taxes |  | $ | (225,304 | ) |  | $ | (200,368 | ) |  | $ | (207,298 | )
Schedule of Components of Deferred Tax Assets and Liabilities | The significant components of our deferred tax assets and liabilities as of the dates presented were as follows (in thousands):
|  | December 31, |
|  | 2023 |  |  | 2022 |
Deferred tax assets |  |  |  |  |  |
Net operating losses |  | $ | 251,724 |  |  | $ | 210,609 |
Tax credit carryforward |  |  | 43,528 |  |  |  | 36,848 |
Nonqualifying stock options |  |  | 29,166 |  |  |  | 23,885 |
Operating lease liabilities |  |  | 25,357 |  |  |  | 27,199 |
Deferred revenue |  |  | 18,874 |  |  |  | 26,170 |
Capitalized research and development |  |  | 42,134 |  |  |  | 40,957 |
Other |  |  | 6,146 |  |  |  | 5,859 |
Total deferred tax assets |  |  | 416,929 |  |  |  | 371,527 |
Less: Valuation allowance |  |  | (402,424 | ) |  |  | (346,578 | )
Deferred tax assets, net of valuation allowance |  |  | 14,505 |  |  |  | 24,949 |
Deferred tax liabilities |  |  |  |  |  |
Tangible and intangible assets |  |  | (1,281 | ) |  |  | (4,897 | )
Right-of-use assets |  |  | (13,224 | ) |  |  | (20,052 | )
Net deferred taxes |  | $ | — |  |  | $ | — |
Schedule of Reconciliation of Effective Tax Rate of Provision for Income Taxes Differs from Federal Statutory Rate | The effective tax rate of our provision for income taxes differs from the federal statutory rate for the periods presented as follows:
|  | Year Ended December 31,
|  | 2023 |  | 2022 |  | 2021
Statutory rate |  | 21.0% |  | 21.0% |  | 21.0%
State tax, net of federal tax benefit |  | 4.0 |  | 3.8 |  | 8.3
Share-based compensation |  | (2.9) |  | (2.0) |  | 14.1
Permanent items |  | (0.1) |  | (0.2) |  | (0.1)
Credits |  | 2.3 |  | 3.0 |  | 4.7
Other |  | 1.0 |  | (1.2) |  | (0.3)
Change in valuation allowance |  | (25.3) |  | (24.4) |  | (47.7)
Total |  | 0.0% |  | 0.0% |  | 0.0%
Schedule of Change in Unrecognized Tax Benefits | A reconciliation of the beginning and ending amounts of unrecognized tax benefits for the dates presented are as follows (in thousands):
Balance at December 31, 2020 |  | $ | 3,489 |
Additions in 2021 |  |  | 3,426 |
Balance at December 31, 2021 |  |  | 6,915 |
Additions in 2022 |  |  | 1,202 |
Balance at December 31, 2022 |  |  | 8,117 |
Additions in 2023 |  |  | 1,186 |
Balance at December 31, 2023 |  | $ | 9,303 |

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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Paragraph 12 -Section 50 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482685/740-10-50-12 + Details
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- Definition Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 15 -Subparagraph (d) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482685/740-10-50-15 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 15A -Publisher FASB -URI https://asc.fasb.org//1943274/2147482685/740-10-50-15A Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 19 -SubTopic 10 -Topic 740 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482685/740-10-50-19 + Details
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