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Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands | Total | Common Stock | Additional Paid In Capital | Accumulated Other Comprehensive Gain (Loss) | Accumulated Deficit | Noncontrolling Interest
--- | --- | --- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2020 | $ 743,266 | $ 14 | $ 1,253,971 | $ 893 | $ (511,612) |
Beginning Balance, Shares at Dec. 31, 2020 |  | 137,646,896 |  |  |  |
Issuance of common stock upon exercise of common stock warrant, Shares |  | 54,162 |  |  |  |
Issuance of common stock for cash upon exercise of stock options | 26,484 |  | 26,484 |  |  |
Issuance of common stock for cash upon exercise of stock options, Shares |  | 3,674,057 |  |  |  |
Vesting of restricted stock units |  | 18,750 |  |  |  |
Share-based compensation | 43,251 |  | 43,251 |  |  |
Capital contributions for Digital Biotechnologies, Inc. | 429 |  | 300 |  |  | $ 129
Other comprehensive (loss) income | (2,030) |  |  | (2,030) |  |
Net loss | (207,298) |  |  |  | (207,279) | (19)
Ending Balance at Dec. 31, 2021 | 604,102 | $ 14 | 1,324,006 | (1,137) | (718,891) | 110
Ending Balance, Shares at Dec. 31, 2021 |  | 141,393,865 |  |  |  |
Issuance of common stock for cash upon exercise of stock options | 7,866 |  | 7,866 |  |  |
Issuance of common stock for cash upon exercise of stock options, Shares |  | 1,406,500 |  |  |  |
Vesting of restricted stock units |  | 304,637 |  |  |  |
Share-based compensation | 55,477 |  | 55,477 |  |  |
Other comprehensive (loss) income | (2,979) |  |  | (2,979) |  |
Net loss | (200,368) |  |  |  | (200,191) | (177)
Ending Balance at Dec. 31, 2022 | 464,098 | $ 14 | 1,387,349 | (4,116) | (919,082) | (67)
Ending Balance, Shares at Dec. 31, 2022 |  | 143,105,002 |  |  |  |
Issuance of common stock for cash upon exercise of stock options | $ 2,245 |  | 2,245 |  |  |
Issuance of common stock for cash upon exercise of stock options, Shares | 470,405 | 470,405 |  |  |  |
Vesting of restricted stock units |  | 1,506,864 |  |  |  |
Share-based compensation | $ 62,908 |  | 62,908 |  |  |
Other comprehensive (loss) income | 4,331 |  |  | 4,331 |  |
Net loss | (225,304) |  |  |  | (225,250) | (54)
Ending Balance at Dec. 31, 2023 | $ 308,278 | $ 14 | $ 1,452,502 | $ 215 | $ (1,144,332) | $ (121)
Ending Balance, Shares at Dec. 31, 2023 |  | 145,082,271 |  |  |  |

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