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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Operating activities    
Net loss $ (125,878) $ (155,837)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation expense 13,533 15,569
Noncash lease expense 3,985 5,491
Share-based compensation expense 40,778 47,352
Intangible assets amortization 1,275 1,270
Investment amortization (6,750) (6,225)
Impairment of long-lived assets 7,205  
Inventory reserve 1,446 931
Noncash interest expense 2,039 4,563
Other 153 165
Changes in operating assets and liabilities    
Accounts receivable, net (2,845) 8,798
Inventory 1,990 (6,815)
Prepaid expenses and other current assets (877) (3,964)
Accounts payable and accrued liabilities (3,593) (10,746)
Operating lease right-of-use assets and liabilities (6,418) (6,688)
Deferred revenue (8,786) (23,180)
Other 22 (76)
Net cash used in operating activities (82,721) (129,392)
Investing activities    
Purchases of property and equipment (3,584) (9,399)
Purchases of marketable securities (199,458) (307,563)
Proceeds from maturities of marketable securities 258,715 443,402
Net cash provided by investing activities 55,673 126,440
Financing activities    
Proceeds from exercise of stock options 114 2,158
Net cash provided by financing activities 114 2,158
Net decrease in cash, cash equivalents and restricted cash (26,934) (794)
Cash, cash equivalents and restricted cash at beginning of year 67,996 92,428
Cash, cash equivalents and restricted cash at end of period 41,062 91,634
Noncash investing activities    
Purchases of equipment included in accounts payable and accrued liabilities 29 1,308
Supplemental disclosure of cash flow information    
Cash paid for interest $ 6,542 $ 7,089