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v3.25.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Operating activities |  |  |
Net loss | $ (159,595) | $ (225,304) | $ (200,368)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Depreciation expense | 17,553 | 20,532 | 19,221
Noncash lease expense | 5,277 | 6,920 | 7,227
Share-based compensation expense | 53,610 | 62,908 | 55,477
Intangible assets amortization | 1,703 | 1,699 | 1,699
Investment amortization | (8,208) | (9,184) | 741
Impairment of long-lived assets | 7,205 | 25,429 |
Inventory reserve | 1,938 | 1,387 | 2,638
Noncash interest expense | 2,618 | 5,300 | 985
Other | 141 | 172 | (19)
Changes in operating assets and liabilities |  |  |
Accounts receivable, net | (3,744) | 2,032 | (22,648)
Inventory | 5,372 | (2,838) | 817
Prepaid expenses and other current assets | 83 | (1,930) | 3,551
Accounts payable and accrued liabilities | 671 | (5,407) | 7,111
Operating lease right-of-use assets and liabilities | (9,385) | (8,676) | (4,050)
Deferred revenue | (10,478) | (29,291) | (56,496)
Other | 27 | (73) | 169
Net cash used in operating activities | (95,212) | (156,324) | (183,945)
Investing activities |  |  |
Purchases of property and equipment | (3,664) | (10,697) | (16,349)
Purchases of marketable securities | (244,257) | (429,558) | (278,778)
Proceeds from maturities of marketable securities | 325,713 | 569,902 | 298,032
Net cash provided by investing activities | 77,792 | 129,647 | 2,905
Financing activities |  |  |
Proceeds from exercise of stock options | 241 | 2,245 | 7,890
Proceeds from revenue interest purchase agreement, net of issuance costs |  |  | 124,375
Net cash provided by financing activities | 241 | 2,245 | 132,265
Net decrease in cash, cash equivalents and restricted cash | (17,179) | (24,432) | (48,775)
Cash, cash equivalents and restricted cash at beginning of year | 67,996 | 92,428 | 141,203
Cash, cash equivalents and restricted cash at end of year | 50,817 | 67,996 | 92,428
Noncash investing activities |  |  |
Purchases of equipment included in accounts payable and accrued liabilities | 1,275 | 687 | 1,719
Supplemental disclosure of cash flow information |  |  |
Cash paid for interest | $ 8,864 | $ 8,985 | $ 494

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