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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2024
Income Tax Disclosure [Abstract] |
Schedule of Components of Loss Before Provision for Income Taxes | The components of loss before provision for income taxes for the periods presented were as follows (in thousands):
|  | Year Ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Domestic |  | $ | (159,635 | ) |  | $ | (225,335 | ) |  | $ | (200,427 | )
Foreign |  |  | 40 |  |  |  | 31 |  |  |  | 59 |
Total loss before provision for income taxes |  | $ | (159,595 | ) |  | $ | (225,304 | ) |  | $ | (200,368 | )
Schedule of Components of Deferred Tax Assets and Liabilities | The significant components of our deferred tax assets and liabilities as of the dates presented were as follows (in thousands):
|  | December 31, |
|  | 2024 |  |  | 2023 |
Deferred tax assets |  |  |  |  |  |
Net operating losses |  | $ | 274,535 |  |  | $ | 251,724 |
Tax credit carryforward |  |  | 45,942 |  |  |  | 43,528 |
Nonqualifying stock options |  |  | 31,010 |  |  |  | 29,166 |
Operating lease liabilities |  |  | 22,912 |  |  |  | 25,357 |
Deferred revenue |  |  | 14,996 |  |  |  | 18,874 |
Capitalized research and development |  |  | 49,550 |  |  |  | 42,134 |
Tangible and intangible assets |  |  | 1,963 |  |  |  | — |
Other |  |  | 6,182 |  |  |  | 6,146 |
Total deferred tax assets |  |  | 447,090 |  |  |  | 416,929 |
Less: Valuation allowance |  |  | (435,509 | ) |  |  | (402,424 | )
Deferred tax assets, net of valuation allowance |  |  | 11,581 |  |  |  | 14,505 |
Deferred tax liabilities |  |  |  |  |  |
Tangible and intangible assets |  |  | — |  |  |  | (1,281 | )
Right-of-use assets |  |  | (11,581 | ) |  |  | (13,224 | )
Net deferred taxes |  | $ | — |  |  | $ | — |
Schedule of Reconciliation of Effective Tax Rate of Provision for Income Taxes Differs from Federal Statutory Rate | The effective tax rate of our provision for income taxes differs from the federal statutory rate for the periods presented as follows:
|  | Year Ended December 31,
|  | 2024 |  | 2023 |  | 2022
Statutory rate |  | 21.0% |  | 21.0% |  | 21.0%
State tax, net of federal tax benefit |  | 3.6 |  | 4.0 |  | 3.8
Share-based compensation |  | (4.7) |  | (2.9) |  | (2.0)
Permanent items |  | (0.3) |  | (0.1) |  | (0.2)
Credits |  | 1.7 |  | 2.3 |  | 3.0
Other |  | (0.6) |  | 1.0 |  | (1.2)
Change in valuation allowance |  | (20.7) |  | (25.3) |  | (24.4)
Total |  | 0.0% |  | 0.0% |  | 0.0%
Schedule of Change in Unrecognized Tax Benefits | A reconciliation of the beginning and ending amounts of unrecognized tax benefits for the dates presented are as follows (in thousands):
Balance at December 31, 2021 |  | $ | 6,915 |
Additions in 2022 |  |  | 1,202 |
Balance at December 31, 2022 |  |  | 8,117 |
Additions in 2023 |  |  | 1,186 |
Balance at December 31, 2023 |  |  | 9,303 |
Additions in 2024 |  |  | 1,407 |
Balance at December 31, 2024 |  | $ | 10,710 |

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