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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2024

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Provision for Income Taxes

The components of loss before provision for income taxes for the periods presented were as follows (in thousands):

		Year Ended December 31,
		2024				2023				2022
Domestic		$	(159,635	)		$	(225,335	)		$	(200,427	)
Foreign			40				31				59
Total loss before provision for income taxes		$	(159,595	)		$	(225,304	)		$	(200,368	)

Schedule of Components of Deferred Tax Assets and Liabilities

The significant components of our deferred tax assets and liabilities as of the dates presented were as follows (in thousands):

		December 31,
		2024				2023
Deferred tax assets
Net operating losses		$	274,535			$	251,724
Tax credit carryforward			45,942				43,528
Nonqualifying stock options			31,010				29,166
Operating lease liabilities			22,912				25,357
Deferred revenue			14,996				18,874
Capitalized research and development			49,550				42,134
Tangible and intangible assets			1,963				—
Other			6,182				6,146
Total deferred tax assets			447,090				416,929
Less: Valuation allowance			(435,509	)			(402,424	)
Deferred tax assets, net of valuation allowance			11,581				14,505
Deferred tax liabilities
Tangible and intangible assets			—				(1,281	)
Right-of-use assets			(11,581	)			(13,224	)
Net deferred taxes		$	—			$	—

Schedule of Reconciliation of Effective Tax Rate of Provision for Income Taxes Differs from Federal Statutory Rate

The effective tax rate of our provision for income taxes differs from the federal statutory rate for the periods presented as follows:

		Year Ended December 31,
		2024		2023		2022
Statutory rate		21.0%		21.0%		21.0%
State tax, net of federal tax benefit		3.6		4.0		3.8
Share-based compensation		(4.7)		(2.9)		(2.0)
Permanent items		(0.3)		(0.1)		(0.2)
Credits		1.7		2.3		3.0
Other		(0.6)		1.0		(1.2)
Change in valuation allowance		(20.7)		(25.3)		(24.4)
Total		0.0%		0.0%		0.0%

Schedule of Change in Unrecognized Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized tax benefits for the dates presented are as follows (in thousands):

Balance at December 31, 2021		$	6,915
Additions in 2022			1,202
Balance at December 31, 2022			8,117
Additions in 2023			1,186
Balance at December 31, 2023			9,303
Additions in 2024			1,407
Balance at December 31, 2024		$	10,710

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of the change in unrecognized tax benefits.

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