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v3.25.3

Segment Information - Schedule of Segment Information, Including Significant Segment Expenses (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment Reporting Information [Line Items] |  |  |  |  |  |
Revenue |  | $ 93,973 | $ 46,435 | $ 205,295 | $ 131,498 |
Cost of revenue |  | 18,157 | 16,667 | 53,135 | 54,035 |
Research and development |  | 23,669 | 24,163 | 72,006 | 79,761 |
Sales and marketing |  | 23,470 | 20,551 | 70,090 | 63,184 |
General and administrative |  | 17,959 | 17,258 | 53,144 | 54,750 |
Share-based compensation expense |  | (13,257) | (13,522) | (38,763) | (40,778) |
Restructuring expense | [1] |  | (193) |  | (1,917) |
Impairment of long-lived assets |  | 0 | 0 | 0 | (7,205) | [1]
Depreciation and amortization expense |  | (3,972) | (4,156) | (12,348) | (13,510) |
Other unallocated items | [2] | (5,950) | (5,305) | (18,119) | (15,928) |
Net income (loss) |  | 9,545 | (32,097) | (45,878) | (125,878) |
Operating Segments |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Revenue |  | 93,973 | 46,435 | 205,295 | 131,498 |
Cost of revenue |  | 17,303 | 14,956 | 49,723 | 47,740 |
Research and development |  | 23,669 | 24,163 | 72,006 | 79,761 |
Sales and marketing |  | 21,832 | 18,761 | 65,199 | 57,804 |
General and administrative |  | 10,739 | 9,622 | 30,372 | 30,254 |
Items to reconcile net loss or net income to Adjusted EBITDA | [3] | 15,176 | 15,460 | 44,716 | 56,110 |
Adjusted EBITDA | [3] | 30,671 | (11,332) | 16,957 | (53,840) |
Operating Segments | MRD |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Revenue |  | 56,788 | 37,470 | 150,447 | 105,380 |
Cost of revenue |  | 17,303 | 14,956 | 49,723 | 47,740 |
Research and development |  | 8,956 | 9,199 | 26,613 | 32,168 |
Sales and marketing |  | 21,832 | 18,761 | 65,199 | 57,804 |
General and administrative |  | 10,739 | 9,622 | 30,372 | 30,254 |
Items to reconcile net loss or net income to Adjusted EBITDA | [3] | 9,007 | 8,948 | 26,226 | 30,737 |
Adjusted EBITDA | [3] | 6,965 | (6,120) | 4,766 | (34,668) |
Operating Segments | Immune Medicine |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Revenue |  | 37,185 | 8,965 | 54,848 | 26,118 |
Research and development |  | 14,713 | 14,964 | 45,393 | 47,593 |
Items to reconcile net loss or net income to Adjusted EBITDA | [3] | 6,169 | 6,512 | 18,490 | 25,373 |
Adjusted EBITDA | [3] | 23,706 | (5,212) | 12,191 | (19,172) |
Operating Segments | MRD and Immune Medicine |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Share-based compensation expense | [4] | (11,204) | (11,111) | (32,368) | (33,478) |
Unallocated Corporate |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Other segment items | [5] | 4,935 | 5,725 | 15,754 | 25,889 |
Unallocated Corporate | MRD |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Other segment items | [5] |  |  |  | 2,819 |
Unallocated Corporate | Immune Medicine |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |
Other segment items | [5] | $ 4,935 | $ 5,725 | $ 15,754 | $ 23,070 |
[1] | Represents expenses recognized in conjunction with restructuring activities. See Note 12, Restructurings for details on our restructuring expense.
[2] | Represents unallocated expenses and income not included in the measurements reviewed by the CODM to assess each segment's performance.
[3] | Adjusted EBITDA is a non-GAAP financial measure. See “Management's Discussion and Analysis of Financial Condition and Results of Operations—Adjusted EBITDA” for an explanation of how it is calculated and used by management.
[4] | Represents share-based compensation expense related to stock option, restricted stock unit and market-based restricted stock unit awards. See Note 11, Equity Incentive Plans for details on our share-based compensation expense.
[5] | For the MRD segment, includes MRD expenses related to the impairment of long-lived assets. For the Immune Medicine segment, includes all Immune Medicine operating expenses, other than research and development expenses.

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