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Segment Information - Schedule of Segment Information, Including Significant Segment Expenses (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2026 | Jun. 30, 2025 | Jun. 30, 2026 | Jun. 30, 2025
Segment Reporting Information [Line Items] |  |  |  |  |  |  |
Revenue |  | $ 71,553 | $ 58,879 |  | $ 142,427 | $ 111,322 |
Cost of revenue |  | 20,165 | 17,999 |  | 38,873 | 34,978 |
Research and development |  | 19,153 | 24,134 |  | 42,776 | 48,337 |
Sales and marketing |  | 26,414 | 23,573 |  | 52,760 | 46,620 |
General and administrative |  | 21,168 | 17,786 |  | 42,152 | 35,185 |
Share-based compensation expense |  | 11,119 | 13,359 |  | 23,047 | 25,506 |
Segment non-cash and restructuring items |  | (12,520) | (15,141) |  | (26,865) | (29,081) |
Other unallocated items | [1] | (30,268) | (6,643) |  | (37,716) | (13,316) |
Net loss |  | (39,941) | (25,593) |  | (59,956) | (55,423) |
Operating Segments |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |
Revenue |  | 71,553 | 58,879 |  | 142,427 | 111,322 |
Cost of revenue |  | 18,891 | 16,535 |  | 36,135 | 32,420 |
Research and development |  | 18,657 | 23,551 |  | 41,817 | 47,198 |
Sales and marketing |  | 24,796 | 21,954 |  | 49,538 | 43,367 |
General and administrative |  | 13,489 | 10,131 |  | 26,008 | 19,633 |
Depreciation and amortization expense |  | 3,235 | 4,040 |  | 6,621 | 8,326 |
Impairment of long-lived assets | [2] |  |  |  | 347 |  |
Restructuring expense | [2] | 77 |  |  | 720 |  |
Share-based compensation expense | [3] | 9,208 | 11,101 |  | 19,177 | 20,755 |
Adjusted EBITDA | [4] | 2,847 | (3,809) |  | 4,625 | (13,026) |
Operating Segments | MRD |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |
Revenue |  | 66,168 | 49,938 |  | 133,261 | 93,659 |
Cost of revenue |  | 18,891 | 16,535 |  | 36,135 | 32,420 |
Research and development |  | 8,610 | 8,498 |  | 17,836 | 17,657 |
Sales and marketing |  | 24,796 | 21,954 |  | 49,538 | 43,367 |
General and administrative |  | 13,489 | 10,131 |  | 26,008 | 19,633 |
Depreciation and amortization expense |  | 2,409 | 2,455 |  | 4,790 | 5,118 |
Restructuring expense | [2] | 77 |  |  | 325 |  |
Share-based compensation expense | [3] | 6,248 | 6,637 |  | 12,395 | 12,101 |
Adjusted EBITDA | [4] | 9,116 | 1,912 |  | 21,254 | (2,199) |
Operating Segments | Immune Medicine |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |
Revenue |  | 5,385 | 8,941 | [1] | 9,166 | 17,663 | [1]
Research and development |  | 10,047 | 15,053 | [1] | 23,981 | 29,541 | [1]
Depreciation and amortization expense |  | 826 | 1,585 | [1] | 1,831 | 3,208 | [1]
Impairment of long-lived assets | [2] |  |  |  | 347 |  |
Restructuring expense | [2] |  |  |  | 395 |  |
Share-based compensation expense | [3] | 2,960 | 4,464 | [1] | 6,782 | 8,654 | [1]
Adjusted EBITDA | [4] | (6,269) | (5,721) | [1] | (16,629) | (10,827) | [1]
Unallocated Corporate |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |
Other segment items | [5] | 5,393 | 5,658 |  | 11,169 | 10,811 |
Unallocated Corporate | Immune Medicine |  |  |  |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |  |  |  |
Other segment items | [5] | $ 5,393 | $ 5,658 | [1] | $ 11,169 | $ 10,811 | [1]
[1] | Costs related to Digital Biotechnologies, Inc. are no longer included as Immune Medicine costs and have been reclassified to the “other unallocated items” total.
[2] | Represents expenses recognized in conjunction with a restructuring that primarily impacted research and development activities.
[3] | Represents share-based compensation expense related to various awards. See Note 12, Equity Incentive Plans for details on our share-based compensation expense.
[4] | Segment Adjusted EBITDA is a non-GAAP financial measure we define as revenue less expenses, adjusted for depreciation and amortization expense, impairment costs for long-lived assets, restructuring expense and share-based compensation expense generated and incurred, respectively, by each segment. Adjusted EBITDA related to our unallocated category is included in the calculation of consolidated Adjusted EBITDA but not shown above in the breakout and aggregation of segment Adjusted EBITDA.
[5] | For the Immune Medicine segment, includes all Immune Medicine operating expenses, other than research and development expenses.

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