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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>9954500 - Disclosure - DERIVATIVE FINANCIAL INSTRUMENT AND HEDGING ACTIVITY (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>9954503 - Disclosure - PROPERTY AND EQUIPMENT, NET - Schedule of property and equipment (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="PROPERTYANDEQUIPMENTNETNarrativeDetails" roleURI="http://www.anipharmaceuticals.com/role/PROPERTYANDEQUIPMENTNETNarrativeDetails">
        <link:definition>9954504 - Disclosure - PROPERTY AND EQUIPMENT, NET - Narrative (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>9954505 - Disclosure - GOODWILL AND INTANGIBLE ASSETS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>9954506 - Disclosure - GOODWILL AND INTANGIBLE ASSETS - Components (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>9954507 - Disclosure - GOODWILL AND INTANGIBLE ASSETS - Amortization (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="FAIRVALUENarrativeDetails" roleURI="http://www.anipharmaceuticals.com/role/FAIRVALUENarrativeDetails">
        <link:definition>9954508 - Disclosure - FAIR VALUE - Narrative (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="FAIRVALUELevel3Details" roleURI="http://www.anipharmaceuticals.com/role/FAIRVALUELevel3Details">
        <link:definition>9954509 - Disclosure - FAIR VALUE - Level 3 (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="FAIRVALUEHierarchyDetails" roleURI="http://www.anipharmaceuticals.com/role/FAIRVALUEHierarchyDetails">
        <link:definition>9954510 - Disclosure - FAIR VALUE - Hierarchy (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="FAIRVALUEAcquiredDetails" roleURI="http://www.anipharmaceuticals.com/role/FAIRVALUEAcquiredDetails">
        <link:definition>9954511 - Disclosure - FAIR VALUE - Acquired (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="MEZZANINEANDSTOCKHOLDERSEQUITYDetails" roleURI="http://www.anipharmaceuticals.com/role/MEZZANINEANDSTOCKHOLDERSEQUITYDetails">
        <link:definition>9954512 - Disclosure - MEZZANINE AND STOCKHOLDERS' EQUITY (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>9954513 - Disclosure - EARNINGS (LOSS) PER SHARE (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:usedOn>link:calculationLink</link:usedOn>
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        <link:definition>9954518 - Disclosure - STOCK-BASED COMPENSATION - RSA activity (Details)</link:definition>
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        <link:definition>9954520 - Disclosure - INCOME TAXES - Narrative (Details)</link:definition>
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      <link:roleType id="INCOMETAXESProvisionDetails" roleURI="http://www.anipharmaceuticals.com/role/INCOMETAXESProvisionDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="INCOMETAXESEffectiverateDetails" roleURI="http://www.anipharmaceuticals.com/role/INCOMETAXESEffectiverateDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="INCOMETAXESDeferredtaxDetails" roleURI="http://www.anipharmaceuticals.com/role/INCOMETAXESDeferredtaxDetails">
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType id="COMMITMENTSANDCONTINGENCIESLeasesexpenseDetails" roleURI="http://www.anipharmaceuticals.com/role/COMMITMENTSANDCONTINGENCIESLeasesexpenseDetails">
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      <link:roleType id="COMMITMENTSANDCONTINGENCIESLeasematurityDetails" roleURI="http://www.anipharmaceuticals.com/role/COMMITMENTSANDCONTINGENCIESLeasematurityDetails">
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      <link:roleType id="PURIFIEDCORTROPHINGELPRELAUNCHCHARGESDetails" roleURI="http://www.anipharmaceuticals.com/role/PURIFIEDCORTROPHINGELPRELAUNCHCHARGESDetails">
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  <xs:element id="anip_PaymentTypeAxis" abstract="true" name="PaymentTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="anip_DerivativeLiabilityDecreaseInNotionalAmount" abstract="false" name="DerivativeLiabilityDecreaseInNotionalAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiabilityCashFlow" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiabilityCashFlow" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_EffectiveIncomeTaxRateReconciliationStateAndForeignIncomeTaxes" abstract="false" name="EffectiveIncomeTaxRateReconciliationStateAndForeignIncomeTaxes" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="anip_CGOncologyInc.Member" abstract="true" name="CGOncologyInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_AdministrativeFeesAndOtherRebatesMember" abstract="true" name="AdministrativeFeesAndOtherRebatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_NumberOfOperatingLeases" abstract="false" name="NumberOfOperatingLeases" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_UnapprovedProductsMember" abstract="true" name="UnapprovedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_SalesOfBrandedPharmaceuticalProductsMember" abstract="true" name="SalesOfBrandedPharmaceuticalProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_AkornHoldingCompanyPipelineProductMember" abstract="true" name="AkornHoldingCompanyPipelineProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_ProductIntellectualPropertyMember" abstract="true" name="ProductIntellectualPropertyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_PublicOfferingMember" abstract="true" name="PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_OakvilleOntarioFormerManufacturingFacilityMember" abstract="true" name="OakvilleOntarioFormerManufacturingFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_IntangibleAssetMeasurementInput" abstract="false" name="IntangibleAssetMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="anip_AcquiredInProcessReserachAndDevelopmentExpense" abstract="false" name="AcquiredInProcessReserachAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_CranfordPharmaceuticalsMember" abstract="true" name="CranfordPharmaceuticalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_EarningsLossBeforeInterestTaxesDepreciationAndAmortization" abstract="false" name="EarningsLossBeforeInterestTaxesDepreciationAndAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_NumberOfProductsMarketed" abstract="false" name="NumberOfProductsMarketed" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_PercentageOfConversionPrice" abstract="false" name="PercentageOfConversionPrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="anip_ProductRightMember" abstract="true" name="ProductRightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_ProjectBasedMilestonePaymentsMember" abstract="true" name="ProjectBasedMilestonePaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_NumberOfConsecutiveTradingDays" abstract="false" name="NumberOfConsecutiveTradingDays" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_ScheduleOfPropertyPlantAndEquipmentUsefulLifeTableTextBlock" abstract="false" name="ScheduleOfPropertyPlantAndEquipmentUsefulLifeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="anip_MeasurementInputProbabilityOfPaymentMember" abstract="true" name="MeasurementInputProbabilityOfPaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_CortrophinPreLaunchChargesTextBlock" abstract="false" name="CortrophinPreLaunchChargesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="anip_NewEmployeesMember" abstract="true" name="NewEmployeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumPotentialToVestPercentage" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumPotentialToVestPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="anip_BusinessCombinationContingentConsiderationArrangementsPeriod" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="anip_OneSupplierMember" abstract="true" name="OneSupplierMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_CommonStockConvertibleConversionRatio" abstract="false" name="CommonStockConvertibleConversionRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="anip_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" abstract="false" name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="anip_AzurityPharmaceuticalsMember" abstract="true" name="AzurityPharmaceuticalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_Mr.MuthusamyShanmugamMember" abstract="true" name="Mr.MuthusamyShanmugamMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_RoyaltyOnFutureSalesPercent" abstract="false" name="RoyaltyOnFutureSalesPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="anip_ClassCSpecialStockValue" abstract="false" name="ClassCSpecialStockValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_DisposalGroupIncludingDiscontinuedOperationConsiderationFirstDeposit" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationConsiderationFirstDeposit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_InterestPeriodDomain" abstract="true" name="InterestPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_BiosantePharmaceuticalsIncMember" abstract="true" name="BiosantePharmaceuticalsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_NovitiumPharmaMember" abstract="true" name="NovitiumPharmaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_ShareBasedCompensationArrangementByShareBasedPaymentAwardEstimateNumberOfSharesPercentage" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEstimateNumberOfSharesPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="anip_ReclassificationOfAssetsOnCompletionOfProjectAndLaunchOfRelatedProductsMember" abstract="true" name="ReclassificationOfAssetsOnCompletionOfProjectAndLaunchOfRelatedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_FairValueMeasurementWithUnobservableInputsReconciliationMeasurementPeriodAdjustment" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationMeasurementPeriodAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_IncreaseDecreaseInRoyaltyPayable" abstract="false" name="IncreaseDecreaseInRoyaltyPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumPotentialToVestShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsMaximumPotentialToVestShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="anip_ANICanadaMember" abstract="true" name="ANICanadaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_AccruedGovernmentRebates" abstract="false" name="AccruedGovernmentRebates" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_PerformanceBasedRestrictedStockUnitsMember" abstract="true" name="PerformanceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_SlaybackPharmaLimitedLiabilityCompanyPatentsAndPendingPatentsMember" abstract="true" name="SlaybackPharmaLimitedLiabilityCompanyPatentsAndPendingPatentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_NumberOfPharmaceuticalManufacturingFacilities" abstract="false" name="NumberOfPharmaceuticalManufacturingFacilities" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_ProductDevelopmentBasedMilestonePaymentsMember" abstract="true" name="ProductDevelopmentBasedMilestonePaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="anip_AcquiredApprovedProductMember" abstract="true" name="AcquiredApprovedProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_TermLoanAndDelayedDrawTermLoanMember" abstract="true" name="TermLoanAndDelayedDrawTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_CortrophinPreLaunchChargesAbstract" abstract="true" name="CortrophinPreLaunchChargesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="anip_CreditAgreementMember" abstract="true" name="CreditAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_OakrumPharmaMember" abstract="true" name="OakrumPharmaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_OakvilleOntarioCanadaMember" abstract="true" name="OakvilleOntarioCanadaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_WellSpringPharmaServicesIncMember" abstract="true" name="WellSpringPharmaServicesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_StockIncentivePlanMember" abstract="true" name="StockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_CustomerOneMember" abstract="true" name="CustomerOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_AllowancesForSalesReturnsMember" abstract="true" name="AllowancesForSalesReturnsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_NumberOfExecutiveFounders" abstract="false" name="NumberOfExecutiveFounders" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_IncreaseDecreaseInReturnedGoodsReserve" abstract="false" name="IncreaseDecreaseInReturnedGoodsReserve" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_SalesOfRareDiseasePharmaceuticalProductsMember" abstract="true" name="SalesOfRareDiseasePharmaceuticalProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_SalesOfGenericPharmaceuticalProductsMember" abstract="true" name="SalesOfGenericPharmaceuticalProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="anip_ContractCustomerMember" abstract="true" name="ContractCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_SsPharmaLlcMember" abstract="true" name="SsPharmaLlcMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_CortrophinPreLaunchCharges" abstract="false" name="CortrophinPreLaunchCharges" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_Mr.ChadGassertMember" abstract="true" name="Mr.ChadGassertMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_NumberOfIntangibleAssetsAcquired" abstract="false" name="NumberOfIntangibleAssetsAcquired" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_LongTermDebtGrossCurrent" abstract="false" name="LongTermDebtGrossCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_ChaliPropertiesLLCMember" abstract="true" name="ChaliPropertiesLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_IncreaseDecreaseAccruedGovernmentRebates" abstract="false" name="IncreaseDecreaseAccruedGovernmentRebates" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_PrepaidIncomeTaxesNet" abstract="false" name="PrepaidIncomeTaxesNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_ThresholdNumberOfTradingDays" abstract="false" name="ThresholdNumberOfTradingDays" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_PreferredStockConvertibleMinimumPeriodOfConversion" abstract="false" name="PreferredStockConvertibleMinimumPeriodOfConversion" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="anip_CustomerFourMember" abstract="true" name="CustomerFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_FDICGuaranteedAmount" abstract="false" name="FDICGuaranteedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_ProductRightsMember" abstract="true" name="ProductRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_ScheduleOfValuationAndQualifyingAccountsDisclosureTableTextBlock" abstract="false" name="ScheduleOfValuationAndQualifyingAccountsDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="anip_AcquiredPipelineProductMember" abstract="true" name="AcquiredPipelineProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_CustomerThreeMember" abstract="true" name="CustomerThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_OneMonthDurationMember" abstract="true" name="OneMonthDurationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_EmployeeStockPurchasePlanTwoThousandAndSixteenMember" abstract="true" name="EmployeeStockPurchasePlanTwoThousandAndSixteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_ProductReturnPeriod" abstract="false" name="ProductReturnPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="anip_SandozIncMember" abstract="true" name="SandozIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_CommonStockConversionPrice" abstract="false" name="CommonStockConversionPrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="anip_AcquiredNDAIntangibleAssetsMember" abstract="true" name="AcquiredNDAIntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_Mr.ShanmugamAndEsjayMember" abstract="true" name="Mr.ShanmugamAndEsjayMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_LongTermDebtGrossNonCurrent" abstract="false" name="LongTermDebtGrossNonCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_AcquiredCommercialProductMember" abstract="true" name="AcquiredCommercialProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_LossContingencyNumberOfManufacturers" abstract="false" name="LossContingencyNumberOfManufacturers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anip_GovernmentRebatesMember" abstract="true" name="GovernmentRebatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_NovitiumMember" abstract="true" name="NovitiumMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_MarketingAndDistributionRightsMember" abstract="true" name="MarketingAndDistributionRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_AlvogenIncMember" abstract="true" name="AlvogenIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_PrivateInvestmentInPublicEquityMember" abstract="true" name="PrivateInvestmentInPublicEquityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_SixMonthDurationMember" abstract="true" name="SixMonthDurationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="anip_StockholdersEquityAttributableToParentAndTemporaryEquity" abstract="false" name="StockholdersEquityAttributableToParentAndTemporaryEquity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anip_NonEmployeeDirectorStockOptionMember" abstract="true" name="NonEmployeeDirectorStockOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_EmployeesAndConsultantsMember" abstract="true" name="EmployeesAndConsultantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_ClassCSpecialStockMember" abstract="true" name="ClassCSpecialStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anip_GenericsEstablishedBrandsAndOtherMember" abstract="true" name="GenericsEstablishedBrandsAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
