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  <xs:element id="qdel_ReallocationOfGoodwill" abstract="false" name="ReallocationOfGoodwill" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_PurchasedTechnologyMember" abstract="true" name="PurchasedTechnologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_PatentsAndTrademarksMember" abstract="true" name="PatentsAndTrademarksMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_ReportingUnitPercentageOfDecreaseInFairValue" abstract="false" name="ReportingUnitPercentageOfDecreaseInFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qdel_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmountAdjustedForDecrease" abstract="false" name="ReportingUnitPercentageOfFairValueInExcessOfCarryingAmountAdjustedForDecrease" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qdel_BankOfAmericaCreditFacilityMember" abstract="true" name="BankOfAmericaCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_CovenantPeriodAxis" abstract="true" name="CovenantPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="qdel_CovenantPeriodDomain" abstract="true" name="CovenantPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_OnOrBeforeJune302023Member" abstract="true" name="OnOrBeforeJune302023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_AfterJune302023ToJune302024Member" abstract="true" name="AfterJune302023ToJune302024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_AfterJune302024ToDecember312024Member" abstract="true" name="AfterJune302024ToDecember312024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_AfterDecember312024ToJune302025Member" abstract="true" name="AfterDecember312024ToJune302025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_AfterJune302025Member" abstract="true" name="AfterJune302025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_DebtInstrumentPaymentPeriodOneMember" abstract="true" name="DebtInstrumentPaymentPeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DebtInstrumentPaymentPeriodTwoMember" abstract="true" name="DebtInstrumentPaymentPeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DebtInstrumentPeriodicPaymentPercentOfInitialPrincipalAmountDue" abstract="false" name="DebtInstrumentPeriodicPaymentPercentOfInitialPrincipalAmountDue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qdel_DebtInstrumentCovenantLeverageRatioMaximum" abstract="false" name="DebtInstrumentCovenantLeverageRatioMaximum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qdel_DebtInstrumentCovenantInterestCoverageRatioMinimum" abstract="false" name="DebtInstrumentCovenantInterestCoverageRatioMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qdel_DerivativeInstrumentsAndOther" abstract="false" name="DerivativeInstrumentsAndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_LeaseNameAxis" abstract="true" name="LeaseNameAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="qdel_LeaseNameDomain" abstract="true" name="LeaseNameDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_SummersRidgeMember" abstract="true" name="SummersRidgeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_NumberOfBuildings" abstract="false" name="NumberOfBuildings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_LesseeOperatingSubleaseOptionToExtendNumberOfAdditionalTerms" abstract="false" name="LesseeOperatingSubleaseOptionToExtendNumberOfAdditionalTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_NonEmployeeDirectorMember" abstract="true" name="NonEmployeeDirectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_EquityIncentivePlanMember" abstract="true" name="EquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_EmployeeDeferredBonusCompensationProgramMember" abstract="true" name="EmployeeDeferredBonusCompensationProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_QuidelOrthoCorporationAmendedAndRestated1983EmployeeStockPurchasePlanESPPMember" abstract="true" name="QuidelOrthoCorporationAmendedAndRestated1983EmployeeStockPurchasePlanESPPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_StockRepurchaseProgramMember" abstract="true" name="StockRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_PercentageOfCashValueOfCashBonusOfficersCouldElectToReceiveInFormOfRestrictedStock" abstract="false" name="PercentageOfCashValueOfCashBonusOfficersCouldElectToReceiveInFormOfRestrictedStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="qdel_LengthOfTimeOfDeferralPeriodUnderConditionOne" abstract="false" name="LengthOfTimeOfDeferralPeriodUnderConditionOne" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qdel_PercentageOfPremiumOnAmountDeferredBasedOnLengthOfTimeForOneYearUnderConditionOne" abstract="false" name="PercentageOfPremiumOnAmountDeferredBasedOnLengthOfTimeForOneYearUnderConditionOne" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="qdel_LengthOfTimeOfDeferralPeriodUnderConditionTwo" abstract="false" name="LengthOfTimeOfDeferralPeriodUnderConditionTwo" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qdel_PercentageOfPremiumOnAmountDeferredBasedOnLengthOfTimeForOneYearUnderConditionTwo" abstract="false" name="PercentageOfPremiumOnAmountDeferredBasedOnLengthOfTimeForOneYearUnderConditionTwo" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="qdel_LengthOfTimeOfDeferralPeriodUnderConditionThree" abstract="false" name="LengthOfTimeOfDeferralPeriodUnderConditionThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qdel_PercentageOfPremiumOnAmountDeferredBasedOnLengthOfTimeForOneYearUnderConditionThree" abstract="false" name="PercentageOfPremiumOnAmountDeferredBasedOnLengthOfTimeForOneYearUnderConditionThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="qdel_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qdel_ShareBasedCompensationExpenseIncreaseFromModificationOfVesting" abstract="false" name="ShareBasedCompensationExpenseIncreaseFromModificationOfVesting" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_SharebasedCompensationArrangementbySharebasedPaymentAwardfairvalueweightedaverageRollForward" abstract="true" name="SharebasedCompensationArrangementbySharebasedPaymentAwardfairvalueweightedaverageRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qdel_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsWeightedAverageGrantDateFairValueRollForward" abstract="true" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsWeightedAverageGrantDateFairValueRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qdel_RoyaltyAndLicenseExpenses" abstract="false" name="RoyaltyAndLicenseExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_NumberOfStockholdersThatFiledComplaints" abstract="false" name="NumberOfStockholdersThatFiledComplaints" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_LossContingencyNumberOfExecutiveDefendants" abstract="false" name="LossContingencyNumberOfExecutiveDefendants" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_InterestRateSwapOneMember" abstract="true" name="InterestRateSwapOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapTwoMember" abstract="true" name="InterestRateSwapTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapThreeMember" abstract="true" name="InterestRateSwapThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapFourMember" abstract="true" name="InterestRateSwapFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapFiveMember" abstract="true" name="InterestRateSwapFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_ForeignExchangeContractsMember" abstract="true" name="ForeignExchangeContractsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_DebtSecurityGovernmentJapanMember" abstract="true" name="DebtSecurityGovernmentJapanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DefinedBenefitPlanEquitySecuritiesJapanMember" abstract="true" name="DefinedBenefitPlanEquitySecuritiesJapanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DefinedBenefitPlanOtherAssetsJapanMember" abstract="true" name="DefinedBenefitPlanOtherAssetsJapanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_NumberOfNonUSPostEmploymentBenefitPlans" abstract="false" name="NumberOfNonUSPostEmploymentBenefitPlans" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_PostretirementHealthCoveragePre65Member" abstract="true" name="PostretirementHealthCoveragePre65Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_PostretirementHealthCoveragePost65Member" abstract="true" name="PostretirementHealthCoveragePost65Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DefinedBenefitPlanEquitySecuritiesNonUSAndNonJapanMember" abstract="true" name="DefinedBenefitPlanEquitySecuritiesNonUSAndNonJapanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DebtSecurityGovernmentNonUSAndNonJapanMember" abstract="true" name="DebtSecurityGovernmentNonUSAndNonJapanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="qdel_DefinedBenefitPlanInsuranceContractMember" abstract="true" name="DefinedBenefitPlanInsuranceContractMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
