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Income Taxes - Difference Between the Effective Tax Rate and the U.S. Federal Statutory Income Tax Rate (Detail)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Tax Disclosure [Abstract]      
Income tax expense at the U.S. federal tax rate 21.00% 21.00% 21.00%
Foreign income tax differential (20.80%) (49.20%) 2.10%
U.S. tax on foreign earnings (16.70%) (8.40%) 2.00%
State and local income taxes 25.00% 58.20% (25.00%)
U.S. permanent book/tax differences (4.20%) (17.00%) (2.70%)
U.S. research and development tax credits 25.00% 68.50% (29.50%)
Change in valuation allowance (25.00%) (49.10%) 27.70%
Tax impact of NOL carry-back under the CARES act. 0.792 0 0
Tax impact of equity compensation (66.70%) (49.30%) (1.40%)
Deferred tax impact from intra-entity IP transfer 6.542 0 0
Tax impact of U.S. Tax Reform/Transition Tax 0 0 (0.239)
Tax Impact of uncertain tax positions (29.20%) (24.60%) 20.20%
Other, net (4.30%) (3.90%) (1.60%)
Effective income tax rate 637.50% (53.80%) (11.10%)