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v3.22.1

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Revenues: |  |
Products, net | $ 188,825 | $ 124,926
Type of Revenue [Extensible List] | us-gaap:ProductMember | us-gaap:ProductMember
Collaboration | $ 22,005 | $ 22,005
Total revenues | 210,830 | 146,931
Cost and expenses: |  |
Cost of sales (excluding amortization of in-licensed rights) | 31,443 | 22,346
Research and development | 194,250 | 195,149
Selling, general and administrative | 71,840 | 71,131
Settlement and license charges | 0 | 10,000
Amortization of in-licensed rights | 178 | 170
Total cost and expenses | 297,711 | 298,796
Operating loss | (86,881) | (151,865)
Other loss, net: |  |
Other expense, net | (17,265) | (15,528)
Total other loss, net | (17,265) | (15,528)
Loss before income tax expense (benefit) | (104,146) | (167,393)
Income tax expense (benefit) | 879 | (143)
Net loss | (105,025) | (167,250)
Other comprehensive loss: |  |
Unrealized losses on investments, net of tax | (286) | (6)
Total other comprehensive loss | (286) | (6)
Comprehensive loss | $ (105,311) | $ (167,256)
Net loss per share - basic and diluted | $ (1.20) | $ (2.10)
Weighted average number of shares of common stock used in computing basic and diluted net loss per share | 87,253 | 79,454

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