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License and Collaboration Agreements - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Product revenues, net | $ 231,495 | $ 188,825 |
Collaborative Arrangement |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Payment for option exercise | 228,800 |  |
Development Milestone and Upfront Fee Recognized as Research and Development Expense | 500 |  |
Collaborative Arrangement | Maximum [Member] |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Contingent research milestone payments | 39,800 |  |
Development Milestone and Settlement Upfront Fee Recognized as Research and Development Expense | 3,100,000 |  |
Development Milestone and Upfront Fee Recognized as Research and Development Expense |  | 100 |
Collaborative Arrangement | Roche Holding A.G. [Member] |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |
Product revenues, net | 22,000 | 22,000 |
Deferred Revenue | 552,200 |  |
Deferred Revenue, Current | 67,200 |  |
Deferred Revenue Separate Material Options Right | 485,000 |  | $ 485,000
Research and development expense | 20,300 | $ 17,700 |
Collaboration Receivable | $ 62,000 |  |

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