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Summary of Stock-Based Compensation Expense by Function Included within Condensed Consolidated Statements of Operations and Comprehensive Loss (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2023 | Mar. 31, 2022
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total stock-based compensation expense | $ 41,250 | $ 29,198
Research and Development [Member] |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total stock-based compensation expense | 16,413 | 13,068
Selling, General and Administrative [Member] |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |
Total stock-based compensation expense | $ 24,837 | $ 16,130

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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