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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 9 Months Ended 282 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Revenues:          
Product sales and rentals   $ 9 $ 2 $ 18 $ 1,879
Research and development agreements         2,105
Grants         9,901
Total revenues   9 2 18 13,885
Costs and expenses:          
Cost of product sales and rentals   2 2 4 3,043
Research and development 6,147 5,750 20,012 15,426 210,717
Selling, general and administrative 2,138 1,696 6,131 5,794 90,979
Total costs and expenses 8,285 7,448 26,145 21,224 304,739
Loss from operations (8,285) (7,439) (26,143) (21,206) (290,854)
Other income (expense):          
Decrease in fair value of warrants 2,241 5,496 3,289 4,286 15,578
Other income         1,249
Interest income 14 12 40 48 10,812
Interest expense (4) (3) (10) (7) (489)
Total other income 2,251 5,505 3,319 4,327 27,150
Net loss (6,034) (1,934) (22,824) (16,879) (263,704)
Accretion of convertible preferred stock 1,218   2,738   3,706
Net loss attributable to common shareholders $ (7,252) $ (1,934) $ (25,562) $ (16,879) $ (267,410)
Net loss per share attributable to common shareholders (Basic and Diluted) (in dollars per share) $ (0.17) $ (0.05) $ (0.63) $ (0.44)  
Weighted average number of common shares outstanding (Basic and Diluted) (in shares) 43,336 38,632 40,331 38,624